Mirabamides are sea
sponge
Sponges or sea sponges are primarily marine invertebrates of the animal phylum Porifera (; meaning 'pore bearer'), a basal clade and a sister taxon of the diploblasts. They are sessile filter feeders that are bound to the seabed, and a ...
isolates that inhibit HIV-1 fusion. Variants A to D are known from ''Siliquariaspongia mirabilis'' and E through H are derived from ''Stelletta clavosa''. Mirabamides have a macrocyclic region closed through an ester bond between the C-terminus and a 𝛽-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid.
Mirabamide G is a fusion of several amino acids:
2,3 diamino butanoic acid,
3-hydroxyleucine,
N-methylthreonine, 2,3-dihydroxy-2,6,8-trimethyldeca-(4''Z'',6''E'')-dienoic acid,
3-methoxy alanine,
β-methoxytyrosine,
3,4-dimethylglutamine.
References
Depsipeptides
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''attribution'': Contains text from the CC/BY/4.0 licensed "Chemical Reactivity Properties, pK
a Values, AGEs Inhibitor Abilities and Bioactivity Scores of the Mirabamides A–H Peptides of Marine Origin Studied by Means of Conceptual DFT" by Lazcano-Perez et al.