Minretumomab (CC49) is a

mouse A mouse ( : mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus' ...

monoclonal antibody that was designed for the treatment of cancers that express the

TAG-72 Tumor-associated glycoprotein 72 (TAG-72) is a glycoprotein found on the surface of many cancer cells, including ovary, breast, colon, lung, and pancreatic cancers. It is a mucin-like molecule with a molar mass of over 1000 kDa. TAG-72 is a tu ...

antigen. This includes breast, colon,

lung The lungs are the primary organs of the respiratory system in humans and most other animals, including some snails and a small number of fish. In mammals and most other vertebrates, two lungs are located near the backbone on either side of t ...

, and

pancreatic The pancreas is an Organ (anatomy), organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the abdominal cavity, abdomen behind the stomach and functions as a gland. The pancreas is a mixed or heterocrine ...

cancers. Apparently, it never got past Phase I clinical trials for this purpose.

Derivatives

A wide range of derivatives has been used in pharmaceutical research. Examples include chimeric and humanized minretumomab, as well as a

fusion protein Fusion proteins or chimeric (kī-ˈmir-ik) proteins (literally, made of parts from different sources) are proteins created through the joining of two or more genes that originally coded for separate proteins. Translation of this ''fusion gene'' r ...

of a minretumomab

single-chain variable fragment A single-chain variable fragment (scFv) is not actually a fragment of an antibody, but instead is a fusion protein of the variable regions of the heavy (VH) and light chains (VL) of immunoglobulins, connected with a short linker peptide of ten ...

and the enzyme beta-lactamase.

Radiopharmaceuticals

Iodine (¹²⁵I) minretumomab is an

iodine-125 Iodine-125 (125I) is a radioisotope of iodine which has uses in biological assays, nuclear medicine imaging and in radiation therapy as brachytherapy to treat a number of conditions, including prostate cancer, uveal melanomas, and brain tumors. ...

radiolabelled derivative that was developed for the detection of tumours in radioimmunoassays such as

CA 72-4 Tumor-associated glycoprotein 72 (TAG-72) is a glycoprotein found on the surface of many cancer cells, including ovary, breast, colon, lung, and pancreatic cancers. It is a mucin-like molecule with a molar mass of over 1000 kDa. TAG-72 is a tu ...

. Radiolabelled minretumomab has also been tested for the treatment of solid tumours, but without success. Iodine ( ¹³¹I) and lutetium ( ¹⁷⁷Lu) minretumomab, for example, were shown to induce

human anti-mouse antibodies Human anti-mouse antibody or human anti-murine antibody (HAMA) is an antibody found in humans which reacts to immunoglobins found in mice. The HAMA response Antibody treatment is a type of therapy that is used to treat certain types of cancer an ...

; no tumour response was observed in Phase I and II

clinical trials Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...

References

{{Monoclonals for tumors, state=collapsed Monoclonal antibodies for tumors