Miguel Rolando Covian
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Miguel Rolando Covian (September 7, 1913 – February 5, 1992), was an
Argentine Argentines, Argentinians or Argentineans are people from Argentina. This connection may be residential, legal, historical, or cultural. For most Argentines, several (or all) of these connections exist and are collectively the source of their ...
-
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ian physiologist, medical educator and writer.


Biography


Early life and education

Covian was born in Rufino,
Santa Fe Province The Invincible Province of Santa Fe (, , lit. "Holy Faith") is a Provinces of Argentina, province of Argentina, located in the center-east of the country. Neighboring provinces are from the north clockwise Chaco Province, Chaco (divided by the 2 ...
,
Argentina Argentina, officially the Argentine Republic, is a country in the southern half of South America. It covers an area of , making it the List of South American countries by area, second-largest country in South America after Brazil, the fourt ...
, on September 7, 1913. He studied at the Faculty of Medicine of the
University of Buenos Aires The University of Buenos Aires (, UBA) is a public university, public research university in Buenos Aires, Argentina. It is the second-oldest university in the country, and the largest university of the country by enrollment. Established in 1821 ...
, where, while a student, he worked also as a teaching assistant in the Chair of
Physiology Physiology (; ) is the science, scientific study of function (biology), functions and mechanism (biology), mechanisms in a life, living system. As a branches of science, subdiscipline of biology, physiology focuses on how organisms, organ syst ...
. He graduated in 1942 and soon thereafter started a full-time career in research on Physiology, initially in collaboration with Bernardo Houssay, the great Argentine physiologist, who later was awarded with the 1947
Nobel Prize The Nobel Prizes ( ; ; ) are awards administered by the Nobel Foundation and granted in accordance with the principle of "for the greatest benefit to humankind". The prizes were first awarded in 1901, marking the fifth anniversary of Alfred N ...
in Medicine and Physiology for his investigation on the interaction between the hypophysis and the
pancreas The pancreas (plural pancreases, or pancreata) is an Organ (anatomy), organ of the Digestion, digestive system and endocrine system of vertebrates. In humans, it is located in the abdominal cavity, abdomen behind the stomach and functions as a ...
in the control of
glucose Glucose is a sugar with the Chemical formula#Molecular formula, molecular formula , which is often abbreviated as Glc. It is overall the most abundant monosaccharide, a subcategory of carbohydrates. It is mainly made by plants and most algae d ...
metabolism Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the co ...
. From 1945 to 1948, Covian worked at the Institute of Experimental Biology and Medicine of Buenos Aires, a private research institution which Houssay and co-workers had founded in 1944, due to his dismissal from the University due to political persecution by the dictatorial regime of Edelmiro Farrell. There, he worked also with another eminent physiologist, Eduardo Braun-Menéndez, and presented his doctoral dissertation in 1948.


Fellowship

After his doctorate Covian went for a post-doctoral fellowship by the
Rockefeller Foundation The Rockefeller Foundation is an American private foundation and philanthropic medical research and arts funding organization based at 420 Fifth Avenue, New York City. The foundation was created by Standard Oil magnate John D. Rockefeller (" ...
, at the
Johns Hopkins University The Johns Hopkins University (often abbreviated as Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland, United States. Founded in 1876 based on the European research institution model, J ...
,
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,
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. There he worked on the physiology of hemidecorticated animals and neurovegetative control, with several important physiologists, such as Phillip Bard, Carl Richter and
Vernon Mountcastle Vernon Benjamin Mountcastle (July 15, 1918 – January 11, 2015) was an American neurophysiologist and Professor Emeritus of Neuroscience at Johns Hopkins University. He discovered and characterized the columnar organization of the cerebral co ...
. He returned three years later to Argentina, to continue his participation at the Institute of Experimental Biology and Medicine, where, in 1952, he established the first experimental laboratory of
neurophysiology Neurophysiology is a branch of physiology and neuroscience concerned with the functions of the nervous system and their mechanisms. The term ''neurophysiology'' originates from the Greek word ''νεῦρον'' ("nerve") and ''physiology'' (whic ...
of Argentina.


Research

In 1955 Covian was already well known internationally for his research on the neurophysiology of the
limbic system The limbic system, also known as the paleomammalian cortex, is a set of brain structures located on both sides of the thalamus, immediately beneath the medial temporal lobe of the cerebrum primarily in the forebrain.Schacter, Daniel L. 2012. ''P ...
. He accepted an invitation from Dr.
Zeferino Vaz Zeferino Vaz (May 27, 1908 – February 19, 1981) was a Brazilian doctor who led the construction, establishment and development of the Unicamp university, in the interior of the State of São Paulo, Brazil in the 1960s and 1970s. The main ...
to join the faculty of the recently founded
School of Medicine of Ribeirão Preto A school is the educational institution (and, in the case of in-person learning, the Educational architecture, building) designed to provide learning environments for the teaching of students, usually under the direction of teachers. Most co ...
of the
University of São Paulo The Universidade de São Paulo (, USP) is a public research university in the Brazilian state of São Paulo, and the largest public university in Brazil. The university was founded on 25 January 1934, regrouping already existing schools in ...
, at
Ribeirão Preto Ribeirão Preto (Portuguese pronunciation: Help:IPA/Portuguese, ibejˈɾɐ̃w ˈpɾetu is a city and a metropolitan area located in the northeastern region of São Paulo (state), São Paulo state, Brazil. Ribeirão Preto is the eighth-la ...
,
São Paulo São Paulo (; ; Portuguese for 'Paul the Apostle, Saint Paul') is the capital of the São Paulo (state), state of São Paulo, as well as the List of cities in Brazil by population, most populous city in Brazil, the List of largest cities in the ...
,
Brazil Brazil, officially the Federative Republic of Brazil, is the largest country in South America. It is the world's List of countries and dependencies by area, fifth-largest country by area and the List of countries and dependencies by population ...
, as the chairman of the Department of Physiology, a post he held until 1974 and from 1978 to 1982. Under Covian's able and humane
leadership Leadership, is defined as the ability of an individual, group, or organization to "", influence, or guide other individuals, teams, or organizations. "Leadership" is a contested term. Specialist literature debates various viewpoints on the co ...
, the Department would grow to become one of the main excellence centers of research and education in
Latin America Latin America is the cultural region of the Americas where Romance languages are predominantly spoken, primarily Spanish language, Spanish and Portuguese language, Portuguese. Latin America is defined according to cultural identity, not geogr ...
, with an excellent scientific staff, with prominent researchers such as Eduardo Krieger, Renato Migliorini,
César Timo-Iaria Cesar or César may refer to: Arts and entertainment * ''César'' (film), a 1936 French romantic drama * ''César'' (play), a play by Marcel Pagnolt Places * Cesar, Portugal * Cesar Department, Colombia * Cesar River, in Colombia * Cesar R ...
,
José Antunes Rodrigues José is a predominantly Spanish and Portuguese form of the given name Joseph. While spelled alike, this name is pronounced very differently in each of the two languages: Spanish ; Portuguese (or ). In French, the name ''José'', pronounced , ...
, José Venâncio Pereira Leite and fellow Argentines Maria Carmelo Lico, Andrés Negro-Vilar and Ricardo F. Marseillan. Covian was involved in all aspects of scientific and educational progress in the physiological sciences. It was there too that Covian founded the first Brazilian laboratory of neurophysiology.


Leadership

Covian was extremely active as a scientific leader. He was one of the founders and a president of the Brazilian Society of Physiology. He also was a strong force behind the graduate programs of the School of Medicine of Ribeirão Preto, and an innovator in the use of new approaches to the teaching of physiology. He was active in the editorial boards of several international scientific journals, such as "Physiology & Behavior" and the monograph series of "
Progress in Brain Research ''Progress in Brain Research'' is a series of academic books on neuroscience published by Elsevier. The first volume appeared in 1963 and , 207 volumes have been published. The editors-in-chief of the series are Stephen Waxman (Yale University Sc ...
", a member to several international committees, the
International Brain Research Organization The International Brain Research Organization (IBRO) is the global federation of neuroscience organizations that aims to promote and support neuroscience around the world. The organization accomplishes this through training, teaching, collaborativ ...
and the Latin American Federation of Physiological Sciences.


Systematic study

Covian's main achievement in neurophysiology was the systematic study, with a large group of collaborators, of the neural basis of
thirst Thirst is the craving for potable fluids, resulting in the basic instinct of animals to drink. It is an essential mechanism involved in fluid balance. It arises from a lack of fluids or an increase in the concentration of certain osmolites, suc ...
, of
neuroendocrine Neuroendocrine cells are cells that receive neuronal input (through neurotransmitters released by nerve cells or neurosecretory cells) and, as a consequence of this input, release messenger molecules ( hormones) into the blood. In this way they b ...
regulation of hydroelectrolytic
homeostasis In biology, homeostasis (British English, British also homoeostasis; ) is the state of steady internal physics, physical and chemistry, chemical conditions maintained by organism, living systems. This is the condition of optimal functioning fo ...
, and of appetitive behavior, i.e., the behavior which permit animals to seek and to ingest particular foodstuffs or
diet Diet may refer to: Food * Diet (nutrition), the sum of the food consumed by an organism or group * Dieting, the deliberate selection of food to control body weight or nutrient intake ** Diet food, foods that aid in creating a diet for weight loss ...
components, an activity which depends on many external and internal factors. The
animal model An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the risk of ha ...
used by Covian's group was the selective ingestion of
water Water is an inorganic compound with the chemical formula . It is a transparent, tasteless, odorless, and Color of water, nearly colorless chemical substance. It is the main constituent of Earth's hydrosphere and the fluids of all known liv ...
versus
salt water Saline water (more commonly known as salt water) is water that contains a high concentration of dissolved salts (mainly sodium chloride). On the United States Geological Survey (USGS) salinity scale, saline water is saltier than brackish wate ...
in albino
Norwegian rat The brown rat (''Rattus norvegicus''), also known as the common rat, street rat, sewer rat, wharf rat, Hanover rat, Norway rat and Norwegian rat, is a widespread species of common rat. One of the largest muroids, it is a brown or grey rodent wi ...
s, which they investigated with many approaches and tools, such as after lesions and stimulations of the
central nervous system The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain, spinal cord and retina. The CNS is so named because the brain integrates the received information and coordinates and influences the activity o ...
, measurement of
metabolic Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the ...
activity, manipulation of the activity of the
endocrine system The endocrine system is a messenger system in an organism comprising feedback loops of hormones that are released by internal glands directly into the circulatory system and that target and regulate distant Organ (biology), organs. In vertebrat ...
, the effect of several kinds of
drugs A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via inhalation, injection, smoking, ingestio ...
, etc. He also studied the role of the
limbic system The limbic system, also known as the paleomammalian cortex, is a set of brain structures located on both sides of the thalamus, immediately beneath the medial temporal lobe of the cerebrum primarily in the forebrain.Schacter, Daniel L. 2012. ''P ...
(particularly the
septal area The septal area (medial olfactory area), consisting of the lateral septum and medial septum, is an area in the lower, posterior part of the medial surface of the frontal lobe, and refers to the nearby septum pellucidum. The septal nuclei are loca ...
) on many behaviors and functions, such as the control of
blood pressure Blood pressure (BP) is the pressure of Circulatory system, circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term ...
, the neuroendocrine regulation of
reproductive behavior The reproductive system of an organism, also known as the genital system, is the biological system made up of all the anatomical organs involved in sexual reproduction. Many non-living substances such as fluids, hormones, and pheromones are al ...
, etc.


Humanist

Covian was also a
humanist Humanism is a philosophical stance that emphasizes the individual and social potential, and agency of human beings, whom it considers the starting point for serious moral and philosophical inquiry. The meaning of the term "humanism" ha ...
, deeply interested in the
history History is the systematic study of the past, focusing primarily on the Human history, human past. As an academic discipline, it analyses and interprets evidence to construct narratives about what happened and explain why it happened. Some t ...
and
philosophy of science Philosophy of science is the branch of philosophy concerned with the foundations, methods, and implications of science. Amongst its central questions are the difference between science and non-science, the reliability of scientific theories, ...
,
history of medicine The history of medicine is both a study of medicine throughout history as well as a multidisciplinary field of study that seeks to explore and understand medical practices, both past and present, throughout human societies. The history of med ...
,
epistemology Epistemology is the branch of philosophy that examines the nature, origin, and limits of knowledge. Also called "the theory of knowledge", it explores different types of knowledge, such as propositional knowledge about facts, practical knowle ...
,
religion Religion is a range of social system, social-cultural systems, including designated religious behaviour, behaviors and practices, morals, beliefs, worldviews, religious text, texts, sanctified places, prophecies, ethics in religion, ethics, or ...
,
classical music Classical music generally refers to the art music of the Western world, considered to be #Relationship to other music traditions, distinct from Western folk music or popular music traditions. It is sometimes distinguished as Western classical mu ...
and erudite
art Art is a diverse range of cultural activity centered around ''works'' utilizing creative or imaginative talents, which are expected to evoke a worthwhile experience, generally through an expression of emotional power, conceptual ideas, tec ...
. He retired at the mandatory age of 70, as a
professor emeritus ''Emeritus/Emerita'' () is an honorary title granted to someone who retirement, retires from a position of distinction, most commonly an academic faculty position, but is allowed to continue using the previous title, as in "professor emeritus". ...
, but continued to appear regularly his office in the department


Death

Honored by his many colleagues, pupils and friends, Covian died on February 5, 1992, following complications of a
stroke Stroke is a medical condition in which poor cerebral circulation, blood flow to a part of the brain causes cell death. There are two main types of stroke: brain ischemia, ischemic, due to lack of blood flow, and intracranial hemorrhage, hemor ...
.


Bibliography

* Covian, MR: Studies on the neurovegetative and behavioral functions of the brain septal area. ''Prog Brain Res.'' 1967;27:189-217. * Covian, MR: ''Fisiologia del Área Septal''. Conferéncias Eduardo Braun Menéndez. Buenos Aires, 1967.


References


External links

* Vicchi, F.L.
O Professor Miguel Rolando Covian
''USP Ribeirão Preto'', Newsletter No. 748, 2002 (In Portuguese).
Interview with Miguel Covian
Center for Logics and Epistemology. State University of Campinas (In Portuguese) {{DEFAULTSORT:Covian, Miguel Rolando 1913 births 1992 deaths People from General López Department Argentine physiologists Argentine emigrants to Brazil Brazilian neuroscientists Brazilian physiologists Johns Hopkins University faculty Academic staff of the University of São Paulo Expatriate academics in Brazil University of Buenos Aires alumni