Michel Bouvier (born September 14, 1958) is a Canadian

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

and molecular

pharmacologist Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur between ...

. He is a professor of biochemistry and molecular medicine at

Université de Montréal The Université de Montréal (; UdeM; ) is a French-language public research university in Montreal, Quebec, Canada. The university's main campus is located in the Côte-des-Neiges neighborhood of Côte-des-Neiges–Notre-Dame-de-Grâce on M ...

; a principal investigator and the chief executive officer at the Institute for Research in Immunology and Cancer; and an associate vice-president in Research, Scientific Discovery, Creation, and Innovation at

. His work focuses on the study of

cell signaling In biology, cell signaling (cell signalling in British English) is the Biological process, process by which a Cell (biology), cell interacts with itself, other cells, and the environment. Cell signaling is a fundamental property of all Cell (biol ...

towards the discovery of new

pharmaceutical drug Medication (also called medicament, medicine, pharmaceutical drug, medicinal product, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy ( pharmacotherapy) is an important part of the ...

Biography

Michel Bouvier earned a B.Sc. in

biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

(1979) and a Ph.D. in neurological sciences (1985) from

, and then completed a postdoctoral fellowship (1985-1989) at

Duke University Duke University is a Private university, private research university in Durham, North Carolina, United States. Founded by Methodists and Quakers in the present-day city of Trinity, North Carolina, Trinity in 1838, the school moved to Durham in 1 ...

under the supervision of

Robert Lefkowitz Robert Joseph Lefkowitz (born April 15, 1943) is an American physician (internist and cardiologist) and biochemist. He is best known for his discoveries that reveal the inner workings of an important family of G protein-coupled receptors, for w ...

(2012 Nobel Prize in Chemistry). Bouvier is a professor in the Department of Biochemistry and Molecular Medicine at the Faculty of Medicine of Université de Montréal and a principal investigator at the Institute for Research in Immunology and Cancer at Université de Montréal.

Research

He is a world-known expert in

and drug discovery, notably in the field of

G protein-coupled receptors G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large protein family, group of evoluti ...

(GPCRs), which constitute the largest single protein family involved in the transduction of hormonal signals and neurotransmitters. Their physiological significance makes them prime targets in drug development, and over a third of existing drugs use GPCRs as their target site of action. Bouvier's work in the regulation of receptors led to new paradigms (inverse agonism; pharmacological chaperones; receptor polymerization; and pluridimensionality of signaling), which, coupled with the development of bioluminescence resonance energy transfer-based methods, have a direct impact on drug discovery. He has authored over 260 scientific articles, filed 36 patent applications, and delivered over 400 lectures as a guest lecturer. Bouvier holds the Canada Research Chair in Signal Transduction and Molecular Pharmacology.

Honours

* 2021 -

Killam Prize The Killam Prize (previously the Izaak Walton Killam Memorial Prize) was established according to the will of Dorothy J. Killam to honour the memory of her husband Izaak Walton Killam. Five Killam Prizes, each having a value of $100,000, were awa ...

in health sciences * 2017 - Wilder-Penfield Prize * 2017 -

Julius Axelrod Julius Axelrod (May 30, 1912 – December 29, 2004) was an American biochemist. He won a share of the Nobel Prize in Physiology or Medicine in 1970 along with Bernard Katz and Ulf von Euler. The Nobel Committee honored him for his work on the ...

pharmacology prize of the

American Society for Pharmacology and Experimental Therapeutics The American Society for Pharmacology and Experimental Therapeutics (ASPET) is a scientific society founded in late 1908 by John Jacob Abel of Johns Hopkins University (also the founder of the American Society for Biochemistry and Molecular Biol ...

* 2014 - Member of the

Royal Society of Canada The Royal Society of Canada (RSC; , SRC), also known as the Academies of Arts, Humanities, and Sciences of Canada (French: ''Académies des arts, des lettres et des sciences du Canada''), is the senior national, bilingual council of distinguishe ...

* 2011 - Adrien-Pouliot Prize -

Association francophone pour le savoir Acfas (previously: Association francophone pour le savoir from 2001 to May 2019 and before, Association canadienne-française pour l'avancement des sciences from 1923 to 2001 "ACFAS" or "Acfas") is the principal French-language learned society in ...

(Acfas) * 2006 -

Léo-Pariseau Prize The Léo-Pariseau Prize is a Québécois prize which is awarded annually to a distinguished individual working in the field of biological or health sciences. The prize is awarded by the Association francophone pour le savoir ( Acfas), and is name ...

(Acfas) * 2005 - Fellow of the

Canadian Academy of Health Sciences The Canadian Academy of Health Sciences (CAHS) is one of three national academies that comprise the Council of Canadian Academies (CCA), the highest honour granted to scholars in Canada. The two other CCA academies are the Royal Society of Cana ...

References

External links

Curriculum vitae
Institute for Research in Immunology and Cancer at the Université de Montréal
Michel Bouvier's lab
{{DEFAULTSORT:Bouvier, Michel 1958 births Living people Canadian biochemists Academic staff of the Université de Montréal Université de Montréal alumni Fellows of the Royal Society of Canada