Sir Michael Anthony Epstein (18 May 1921 – 6 February 2024) was a British

pathologist Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...

and academic. He was one of the discoverers of the

Epstein–Barr virus The Epstein–Barr virus (EBV), also known as human herpesvirus 4 (HHV-4), is one of the nine known Herpesviridae#Human herpesvirus types, human herpesvirus types in the Herpesviridae, herpes family, and is one of the most common viruses in ...

, along with

Yvonne Barr Yvonne Margaret Balding (; 11 March 1932 – 13 February 2016) was an Irish virologist when co-discovered the Epstein–Barr virus (EBV), which, because it identified a virus as a cause of cancer in humans, has been called "one of the 20th cent ...

and

Bert Achong Bert Geoffrey Achong (6 December 1928 – 20 November 1996) was a Trinidadian-born pathologist known for co-discovering the Epstein–Barr virus through use of Electron microscope, electron microscopy. Career Achong was born in Trinidad and T ...

Early life

Epstein was born in London on 18 May 1921, and educated at

St Paul's School, London St Paul's School is a Selective school, selective Private schools in the United Kingdom, independent day school (with limited boarding school, boarding) for boys aged 13–18, founded in 1509 by John Colet and located on a 43-acre site by Rive ...

;

Trinity College, Cambridge Trinity College is a Colleges of the University of Cambridge, constituent college of the University of Cambridge. Founded in 1546 by King Henry VIII, Trinity is one of the largest Cambridge colleges, with the largest financial endowment of any ...

; and

Middlesex Hospital Medical School Middlesex Hospital was a teaching hospital located in the Fitzrovia area of London, England. First opened as the Middlesex Infirmary in 1745 on Windmill Street, it was moved in 1757 to Mortimer Street where it remained until it was finally clo ...

Career

Epstein was Professor of

Pathology Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...

(1968–1985) and head of department (1968–1982) at the

University of Bristol The University of Bristol is a public university, public research university in Bristol, England. It received its royal charter in 1909, although it can trace its roots to a Merchant Venturers' school founded in 1595 and University College, Br ...

. He was a

fellow A fellow is a title and form of address for distinguished, learned, or skilled individuals in academia, medicine, research, and industry. The exact meaning of the term differs in each field. In learned society, learned or professional society, p ...

Wolfson College, Oxford Wolfson College () is a Colleges of the University of Oxford, constituent college of the University of Oxford in England. Wolfson is an all-graduate college, it prides itself on being one of the most international colleges at Oxford, with part ...

, from 1986 until 2001, and was an honorary fellow from 2001 until his death. In 1979 he was elected a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...

(FRS) and was its vice-president from 1986 to 1991. He was awarded its

Royal Medal The Royal Medal, also known as The Queen's Medal and The King's Medal (depending on the gender of the monarch at the time of the award), is a silver-gilt medal, of which three are awarded each year by the Royal Society. Two are given for "the mo ...

in 1992. Epstein was appointed

Commander of the Order of the British Empire The Most Excellent Order of the British Empire is a British order of chivalry, rewarding valuable service in a wide range of useful activities. It comprises five classes of awards across both civil and military divisions, the most senior two o ...

(CBE) in the

1985 Birthday Honours Queen's Birthday Honours are announced on or around the date of the Queen's Official Birthday in Canada, New Zealand and the United Kingdom. The dates vary, both from year to year and from country to country. All are published in supplements to t ...

, and

knighted A knight is a person granted an honorary title of a knighthood by a head of state (including the pope) or representative for service to the monarch, the church, or the country, especially in a military capacity. The concept of a knighthood ...

in the 1991 New Year Honours. Epstein was also a founding Fellow of the

Academy of Medical Sciences The Academy of Medical Sciences is an organisation established in the UK in 1998. It is one of the four UK National Academy, National Academies, the others being the British Academy, the Royal Academy of Engineering and the Royal Society. Its ...

in 1998. In 2006, Epstein was awarded a

Doctor of Science A Doctor of Science (; most commonly abbreviated DSc or ScD) is a science doctorate awarded in a number of countries throughout the world. Africa Algeria and Morocco In Algeria, Morocco, Libya and Tunisia, all universities accredited by the s ...

(DSc) degree by Bristol.

Burkitt lymphoma studies

Epstein was the first person to propose that

Burkitt's lymphoma Burkitt's lymphoma is a cancer of the lymphatic system, particularly B lymphocytes found in the germinal center. It is named after Denis Parsons Burkitt, the Irish surgeon who first described the disease in 1958 while working in equatorial Africa ...

was a cancer caused by a virus. Upon hearing a lecture given by surgeon

Denis Parsons Burkitt Denis Parsons Burkitt, MD, FRCS(Ed), FRS (28 February 1911 – 23 March 1993) was an Irish surgeon who made significant advances in health, such as the aetiology of a pediatric cancer, now called Burkitt's lymphoma, and the finding that rate ...

in 1961 about this newly described cancer, Epstein changed his research focus from cancer-causing viruses in chickens to searching for a viral origin of Burkitt's lymphoma. After more than two years of working with tumour cells from Burkitt's patients and subsequently working to isolate a virus from them, the Epstein–Barr virus was finally discovered in February 1964. In a tribute to Epstein in his 100th year, the European Association for Haematopathology noted that his "perseverance, rigorous scientific observations and a bit of serendipity" resulted in the first cell culture in suspension from human lymphocytes. In 1963, a flight from Uganda was supposed to deliver fresh tumour samples into a foggy London. The flight was diverted to Manchester causing a delay in delivery. When the samples finally arrived into London, they seemed useless, containing a cloudy fluid. However, under the microscope the cloudiness was not due to bacteria, as originally thought, but to huge numbers of viable, free-floating lymphoma cells. Thus, the first cell culture of Burkitt lymphoma was achieved, designated EB cells. In 1964, using electron microscopy, Anthony Epstein and his research assistant

discovered viral particles in EB cells, resulting in the seminal paper published in 1964, "Virus particles in cultured lymphoblasts from Burkitt's lymphoma" by Epstein, Achong and Barr. This was the first demonstration of viral particles in a human tumour.

Personal life and death

In 1950, Epstein married Lisbeth Knight. Together they had three children: a daughter and two sons. They separated in 1965. In later life, his long-term partner was the virologist Kate Ward. Epstein

turned 100 A centenarian is a person who has reached the age of 100. Because life expectancies at birth worldwide are well below 100, the term is invariably associated with longevity. The United Nations estimated that there were 316,600 living centenarian ...

in May 2021. He died on 6 February 2024 at his home in London, at the age of 102. He was a Patron of

Humanists UK Humanists UK, known from 1967 until May 2017 as the British Humanist Association (BHA), is a charitable organisation which promotes secular humanism and aims to represent Irreligion in the United Kingdom, non-religious people in the UK throug ...

References

External links

Epstein-Barr virus, Sir Anthony Epstein FRS
{{DEFAULTSORT:Epstein, Anthony 1921 births 2024 deaths People educated at St Paul's School, London Alumni of Trinity College, Cambridge 20th-century British biologists Academics of the University of Bristol British humanists British virologists Commanders of the Order of the British Empire Fellows of the Academy of Medical Sciences (United Kingdom) Fellows of the Royal Society Jewish British scientists Knights Bachelor British men centenarians Royal Medal winners Scientists from London Jewish centenarians Jewish humanists