__NOTOC__
The MicC
non-coding RNA (previously known as IS063 ) is located between the ''ompN'' and ''ydbK''
genes in ''
E. coli
''Escherichia coli'' (),Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. also known as ''E. coli'' (), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus ''Escher ...
''. This Hfq-associated RNA is thought to be a regulator of the expression level of the OmpC
porin protein, with a
5′
Directionality, in molecular biology and biochemistry, is the end-to-end chemical orientation of a single strand of nucleic acid. In a single strand of DNA or RNA, the chemical convention of naming carbon atoms in the nucleotide pentose-sugar-ri ...
region of 22 nucleotides potentially forming an
antisense interaction with the ''ompC''
mRNA. Along with
MicF RNA
The micF RNA is a non-coding RNA stress response gene found in ''Escherichia coli'' and related bacteria that post-transcriptionally controls expression of the outer membrane porin gene ompF. The micF gene encodes a non-translated 93 nucleotide a ...
this family may act in conjunction with EnvZ-OmpR
two-component system
In the field of molecular biology, a two-component regulatory system serves as a basic stimulus-response coupling mechanism to allow organisms to sense and respond to changes in many different environmental conditions. Two-component systems t ...
to control the OmpF/OmpC protein ratio in response to a variety of environmental stimuli. The expression of ''micC'' was shown to be increased in the presence of
beta-lactam antibiotics.
See also
*
Two-component regulatory system
References
Further reading
*
External links
*
Non-coding RNA
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