Metyltetraprole is a
quinone outside inhibitor fungicide sold under the brand name Pavecto by its inventor,
Sumitomo Chemical.
[ ISSN-Lbr>0385-1559]
/ref> It is the only tetrazolinone fungicide and the only one in the Fungicide Resistance Action Committee
Fungicides are pesticides used to kill parasitic fungi or their spores. Fungi can cause serious damage in agriculture, resulting in losses of yield and quality. Fungicides are used both in agriculture and to fight fungal infections in animals, in ...
's subgroup 11A.
Development
Metyltetraprole was developed specifically to find an a.i. with the same mode of action
In pharmacology and biochemistry, mode of action (MoA) describes a functional or anatomical change, resulting from the exposure of a living organism to a substance. In comparison, a mechanism of action (MOA) describes such changes at the molecul ...
(a QI) but with sufficiently different chemistry as to avoid "critical" QI resistance increasing around the world.
Target pathogens
Metyltetraprole is highly effective against '' Alternaria triticina''.
Resistance
Developed because of increasing resistance to the main group of QIs. See Development
Development or developing may refer to:
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above.
Cross-resistance
It does not suffer cross-resistance with the resistance against 11 conferred by the cytochrome b
Cytochrome b is a protein found in the membranes of aerobic cells. In eukaryotic mitochondria (inner membrane) and in aerobic prokaryotes, cytochrome b is a component of respiratory chain complex III () — also known as the bc1 complex or ubiq ...
mutation G143A. Cross-resistance against F129L is unassessed.
Binding Mode
The structure of the tetrazolinone pharmacophore is very similar to the triazolone pharmacophore of an inhibitor developed by AgoEva, for which the binding mode has been elucidated in the structure deposited a
3L73
in the protein databank.
References
{{agriculture-stub
Fungicides
Tetrazoles
4-Chlorophenyl compounds
Pyrazoles