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HDMP-28 or methylnaphthidate is a piperidine based 
Most of the TMP analogs of HDMP-28 have SERT Ki values in the range >10,000 and so are selective for dopamine and noradrenaline reuptake, with little or no effect on serotonin. HDMP-28 has high affinity to SERT, and so behaves as a
stimulant
Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and inv ...
drug, closely related to methylphenidate, but with the benzene ring replaced by naphthalene
Naphthalene is an organic compound with formula . It is the simplest polycyclic aromatic hydrocarbon, and is a white crystalline solid with a characteristic odor that is detectable at concentrations as low as 0.08 ppm by mass. As an aromati ...
. It is a potent dopamine reuptake inhibitor, with several times the potency of methylphenidate and a short duration of action, and is a structural isomer
In chemistry, a structural isomer (or constitutional isomer in the IUPAC nomenclature) of a chemical compound, compound is another compound whose molecule has the same number of atoms of each element, but with logically distinct chemical bond, b ...
of another potent dopamine reuptake inhibitor, N,O-Dimethyl-4-(2-naphthyl)piperidine-3-carboxylate.
Most of the TMP analogs of HDMP-28 have SERT Ki values in the range >10,000 and so are selective for dopamine and noradrenaline reuptake, with little or no effect on serotonin. HDMP-28 has high affinity to SERT, and so behaves as a triple reuptake inhibitor
Triple is used in several contexts to mean "threefold" or a "treble":
Sports
* Triple (baseball), a three-base hit
* A basketball three-point field goal
* A figure skating jump with three rotations
* In bowling terms, three strikes in a row
* In ...
.
D.R. = Discrimination Ratio = HA ÷ HFT.
A low D.R. = addictive, whereas a high D.R. = low propensity for self-administration.
Legality
HDMP-28 is illegal in Switzerland as of December 2015.See also
*3-Bromomethylphenidate
3-Bromomethylphenidate (3-Br-MPH) is a compound from the phenidate family, which has reportedly been sold as a designer drug. It showed the most potent binding to the dopamine transporter of a series of ring-substituted methylphenidate derivative ...
* 3,4-Dichloromethylphenidate
3,4-Dichloromethylphenidate (also known as 3,4-CTMP or 3,4-DCMP) is a stimulant drug related to methylphenidate. Dichloromethylphenidate is a potent psychostimulant that acts as both a dopamine reuptake inhibitor and norepinephrine reuptake inh ...
* BMAPN
BMAPN (βk-methamnetamine) is a substituted cathinone derivative with stimulant effects. It inhibits dopamine reuptake and has rewarding and reinforcing properties in animal studies. It is banned under drug analogue legislation in a number of ju ...
* Ethylphenidate
* HDEP-28
* Naphthylisopropylamine
* Naphyrone
* 2β-Propanoyl-3β-(2-naphthyl)-tropane
2β-Propanoyl-3β-(2-naphthyl)-tropane or WF-23 (Wake Forest-23, named after the university where it was first created) is a cocaine analogue. It is several hundred times more potent than cocaine at being a serotonin-norepinephrine-dopamine reu ...
(WF-23)
* Isopropylphenidate
* Propylphenidate
References
{{Monoamine reuptake inhibitors 2-Piperidinyl compounds Dopamine reuptake inhibitors Stimulants Designer drugs 2-Naphthyl compounds