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Meth mouth is a colloquial term used to describe severe
tooth decay Tooth decay, also known as caries,The word 'caries' is a mass noun, and is not a plural of 'carie'.'' is the breakdown of teeth due to acids produced by bacteria. The resulting cavities may be a number of different colors, from yellow to black ...
and
tooth loss Tooth loss is a process in which one or more teeth come loose and fall out. Tooth loss is normal for deciduous teeth, deciduous teeth (baby teeth), when they are replaced by a person's permanent teeth, adult teeth. Otherwise, losing teeth is unde ...
, as well as tooth fracture,
acid erosion Acid erosion is a type of tooth wear. It is defined as the irreversible loss of tooth structure due to chemical dissolution by acids not of bacterial origin. Dental erosion is the most common chronic condition of children ages 5–17, altho ...
, and other oral problems that are often
correlated In statistics, correlation or dependence is any statistical relationship, whether causal or not, between two random variables or bivariate data. Although in the broadest sense, "correlation" may indicate any type of association, in statistic ...
with extended use of the drug
methamphetamine Methamphetamine (contracted from ) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug use, recreational or Performance-enhancing substance, performance-enhancing drug and less commonly as a secon ...
. The condition is thought to be caused by a combination of side effects of the drug (clenching and grinding of teeth, dry mouth) and lifestyle factors (infrequent
oral hygiene Oral hygiene is the practice of keeping one's oral cavity clean and free of disease and other problems (e.g. bad breath) by regular brushing of the teeth (dental hygiene) and adopting good hygiene habits. It is important that oral hygiene be carr ...
, frequent consumption of sugary drinks, as well as neglecting regular dental cleanings and preventive care), which may be present in long-term users. However, the legitimacy of meth mouth as a unique condition has been questioned because of the similar effects of some other drugs on teeth. Images of diseased mouths are often used in anti-drug campaigns. The condition is difficult to treat, and may involve fillings,
fluoride Fluoride (). According to this source, is a possible pronunciation in British English. is an Inorganic chemistry, inorganic, Monatomic ion, monatomic Ion#Anions and cations, anion of fluorine, with the chemical formula (also written ), whose ...
to fight tooth decay and drugs that increase
saliva Saliva (commonly referred as spit or drool) is an extracellular fluid produced and secreted by salivary glands in the mouth. In humans, saliva is around 99% water, plus electrolytes, mucus, white blood cells, epithelial cells (from which ...
for dry mouth, as well as oral hygiene instruction. It can be dangerous for active methamphetamine users to undergo dental surgery because of the cardiac problems that can result from the interaction of
local anesthetic A local anesthetic (LA) is a medication that causes absence of all sensation (including pain) in a specific body part without loss of consciousness, providing local anesthesia, as opposed to a general anesthetic, which eliminates all sensati ...
with the drug.


Signs and symptoms

Methamphetamine Methamphetamine (contracted from ) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug use, recreational or Performance-enhancing substance, performance-enhancing drug and less commonly as a secon ...
(informally referred to as "meth") is a stimulant drug with a high potential for addiction in its recreational users. It incurs physical and psychological side effects that users find desirable. Other side effects (like
bruxism Bruxism is excessive teeth grinding or jaw clenching. It is an oral Parafunctional habit, parafunctional activity; i.e., it is unrelated to normal function such as eating or talking. Bruxism is a common behavior; the global prevalence of brux ...
and
stimulant psychosis Stimulant psychosis is a mental disorder characterized by psychotic symptoms such as hallucinations, paranoid ideation, delusions, disorganized thinking, and grossly disorganized behaviour. It typically occurs following an overdose or several ...
) can result in users neglecting their dental health, eventually leading to advanced
tooth decay Tooth decay, also known as caries,The word 'caries' is a mass noun, and is not a plural of 'carie'.'' is the breakdown of teeth due to acids produced by bacteria. The resulting cavities may be a number of different colors, from yellow to black ...
(caries) and gum
infections An infection is the invasion of tissue (biology), tissues by pathogens, their multiplication, and the reaction of host (biology), host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmis ...
. Further, a common side effect of stimulant drugs is
xerostomia Xerostomia, also known as dry mouth, is a subjective complaint of dryness in the mouth, which may be associated with a change in the composition of saliva, reduced salivary flow, or have no identifiable cause. This symptom is very common and is o ...
, which accelerates tooth decay. , methamphetamine is the most discussed illegal drug in dental literature for its extensive effect on users' dental health. The teeth of some methamphetamine users appear to be dark and extensively eroded. The epithet "meth mouth" is the result of these superficial presentations of advanced tooth decay and gum infection. Caries often occur in the cervical regions of teeth, where the tooth surface narrows at the junction of the
crown A crown is a traditional form of head adornment, or hat, worn by monarchs as a symbol of their power and dignity. A crown is often, by extension, a symbol of the monarch's government or items endorsed by it. The word itself is used, parti ...
and the root; decay is primarily centered on the buccal (
cheek The cheeks () constitute the area of the face below the eyes and between the nose and the left or right ear. ''Buccal'' means relating to the cheek. In humans, the region is innervated by the buccal nerve. The area between the inside of th ...
) side of the teeth, and on tooth surfaces that are adjacent to
incisors Incisors (from Latin ''incidere'', "to cut") are the front teeth present in most mammals. They are located in the premaxilla above and on the mandible below. Humans have a total of eight (two on each side, top and bottom). Opossums have 18, wher ...
and canines. Eventually, the coronal tooth area (near the crown) can be affected by the decay and erosion. The dental caries of meth mouth often progress slowly, perhaps because their advancement is hindered by intermittent hygienic practices. The decay can lead to tooth fractures and severe pain. In some cases, teeth are permanently damaged and must be removed. Along with
malnutrition Malnutrition occurs when an organism gets too few or too many nutrients, resulting in health problems. Specifically, it is a deficiency, excess, or imbalance of energy, protein and other nutrients which adversely affects the body's tissues a ...
and weight loss, the dental effects of methamphetamine use contribute to the appearance of premature aging seen in some users. Methamphetamine users sometimes experience soreness in the joint of the jaw and dental attrition (tooth wear) due to bruxism, a common side effect of stimulant drugs. This bruxism can occur continuously. Chronic use of the drug might also cause
trismus Trismus is a condition of restricted opening of the mouth. The term was initially used in the setting of tetanus. Trismus may be caused by spasm of the muscles of mastication or a variety of other causes. Temporary trismus occurs much more freque ...
, the inability to open the jaw. The effects of meth mouth are similar to those of Sjögren's syndrome, an
autoimmune disease An autoimmune disease is a condition that results from an anomalous response of the adaptive immune system, wherein it mistakenly targets and attacks healthy, functioning parts of the body as if they were foreign organisms. It is estimated tha ...
that causes a lack of
saliva Saliva (commonly referred as spit or drool) is an extracellular fluid produced and secreted by salivary glands in the mouth. In humans, saliva is around 99% water, plus electrolytes, mucus, white blood cells, epithelial cells (from which ...
, which results in tooth decay.


Causes

The hypothesized causes of meth mouth are a combination of MA side effects and lifestyle factors which may be present in users: * Dry mouth (xerostomia) * Clenching and grinding of the teeth (bruxism) * Infrequent oral hygiene * Frequent consumption of sugary, fizzy drinks * Caustic nature of methamphetamine The dental effects of long-term methamphetamine use are often attributed to its effects on saliva. The reduction in saliva increases the likelihood of dental caries, enamel erosion, and
periodontal disease Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the tissues surrounding the teeth. In its early stage, called gingivitis, the gums become swollen and red and may bleed. It is considered the main c ...
. Although it is clear that use of the drug decreases saliva, the mechanism by which it does so is unclear. One theory is that the drug causes
vasoconstriction Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles. The process is the opposite of vasodilation, the widening of blood vesse ...
(narrowing of the blood vessels) in
salivary gland The salivary glands in many vertebrates including mammals are exocrine glands that produce saliva through a system of ducts. Humans have three paired major salivary glands ( parotid, submandibular, and sublingual), as well as hundreds of min ...
s, decreasing salivary flow. This constriction is thought to be due to the activation of alpha-adrenergic receptors by both methamphetamine itself and
norepinephrine Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic compound, organic chemical in the catecholamine family that functions in the brain and human body, body as a hormone, neurotransmitter and neuromodulator. The ...
, the levels of which are dramatically increased by methamphetamine use. These factors can be compounded by dehydration, which occurs in many methamphetamine users after drug-induced increases in
metabolism Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the co ...
. The characteristics of the saliva produced during use of the drug, which includes high protein content, may also contribute to the sensation of dry mouth. Long-term methamphetamine use can cause
parafunctional habit A para-functional habit or parafunctional habit is the habitual exercise of a body part in a way that is other than the most common use of that body part. In dentistry, orthodontics, and oral and maxillofacial pathology, the body part in question ...
s, routine actions of a body part that are different from their common use, which can result in tooth wear and exacerbate periodontal diseases. One such habit that may affect the development of meth mouth is bruxism, particularly as the drug's effects wane and
stereotypy A stereotypy (, ) is a repetitive or ritualistic movement, posture, or utterance. Stereotypies may be simple movements such as body rocking, or complex, such as self-caressing, crossing and uncrossing of legs, and marching in place. They are foun ...
occurs, a phase that is often referred to as "tweaking". This bruxism may be due to a drug-induced increase in
monoamines Monoamine neurotransmitters are neurotransmitters and neuromodulators that contain one amino group connected to an aromaticity, aromatic ring by a two-carbon chain (such as -CH2-CH2-). Examples are dopamine, norepinephrine and serotonin. All m ...
. Other behaviors of long-term methamphetamine users that may cause or accelerate the symptoms of meth mouth are the failure to pay attention to oral hygiene and excessive food intake during binges, especially sugary foods; the drug's users often report strong cravings for sugar and consume large amounts of high-sugar beverages. The altered mental state that accompanies methamphetamine use lasts longer than that of some other common drugs, increasing the amount of time the user engages in drug-induced behavior.
Hydrochloric acid Hydrochloric acid, also known as muriatic acid or spirits of salt, is an aqueous solution of hydrogen chloride (HCl). It is a colorless solution with a distinctive pungency, pungent smell. It is classified as a acid strength, strong acid. It is ...
is used in methamphetamine's manufacturing process, but academic reviews have not supported the idea that the acid contributes to dental decay. Speculation that oral consumption of the drug causes tooth decay by raising the acidity of users' mouths is also unsupported. Meth mouth is generally most severe in users who inject the drug, rather than those who smoke, ingest or
inhale Inhalation (or inspiration) happens when air or other gases enter the lungs. Inhalation of air Inhalation of air, as part of the cycle of breathing, is a vital process for all human life. The process is autonomic (though there are exceptions ...
it.


Treatment

The damaging effects of meth mouth on the teeth and gums for the most part are irreversible, although, if treated at an early stage, they can be dramatically reduced through the habitual use of common hygienic practices; Under normal circumstances, the user will not seek a remedy until the damage has already begun to take control causing severe mouth pain and general discomfort. Because many drug users lack the access to dental treatment, due to affordability and poverty, it is important to take medical precautions to prolong the lifespan of the mouth, and health in general. Those who are willing to seek dental treatment should seek professional advice as soon as possible if they are experiencing any painful symptoms relatable to meth mouth from abusing methamphetamine. Providing dental treatment to individuals who use methamphetamine can be dangerous, because the potential combination of
local anesthetic A local anesthetic (LA) is a medication that causes absence of all sensation (including pain) in a specific body part without loss of consciousness, providing local anesthesia, as opposed to a general anesthetic, which eliminates all sensati ...
and methamphetamine can cause serious heart problems. There is also an increased risk of serious side effects if
opioid Opioids are a class of Drug, drugs that derive from, or mimic, natural substances found in the Papaver somniferum, opium poppy plant. Opioids work on opioid receptors in the brain and other organs to produce a variety of morphine-like effects, ...
medications are used in the patient's treatment. Treatment of meth mouth usually attempts to increase the flow of saliva, halt tooth decay, and encourage behavioral changes.
Toothpaste Toothpaste is a paste or gel dentifrice that is used with a toothbrush to clean and maintain the aesthetics of Human tooth, teeth. Toothpaste is used to promote oral hygiene: it is an abrasive that aids in removing dental plaque and food from th ...
with
fluoride Fluoride (). According to this source, is a possible pronunciation in British English. is an Inorganic chemistry, inorganic, Monatomic ion, monatomic Ion#Anions and cations, anion of fluorine, with the chemical formula (also written ), whose ...
is very important to the restoration of dental health. Prescription fluoride rinses can adequately treat the condition as well.
Sialogogue A sialogogue (also spelled sialagogue, ptysmagogue or ptyalagogue) is a substance, especially a medication, that increases the flow rate of saliva. The definition focuses on substances that promote production or secretion of saliva (proximal caus ...
s, drugs that increase the amount of saliva in the mouth, can be used to treat dry mouth and protect against dental health problems.
Pilocarpine Pilocarpine, sold under the brand name Pilopine HS among others, is a lactone alkaloid originally extracted from plants of the Pilocarpus genus. It is used as a medication to reduce pressure inside the eye and treat dry mouth. As an eye drop ...
and
cevimeline Cevimeline (trade name Evoxac) is a synthetic analog of the natural alkaloid muscarine with a particular agonistic effect on M1 and M3 receptors. It is used in the treatment of dry mouth and Sjögren's syndrome. Medical uses Cevimeline is u ...
are sialogogues approved by the
Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...
(FDA) to treat low salivation caused by
Sjögren syndrome Sjögren is a Swedish surname. Notable people with the surname include: * Anders Johan Sjögren (1794–1855), Finnish linguist, historian, ethnographer and explorer * Ann Mari Sjögren, Swedish fantasy artist and illustrator * Christer Sjögren, ...
and may have the potential to effectively treat dry mouth caused by methamphetamine use.


Uncertainty

There have not been any controlled studies on meth mouth, and several of its aspects are unclear. Although the condition has been popularized by media coverage and case reports, no systematic studies have been conducted to conclusively tie methamphetamine use to symptoms that are commonly described as meth mouth. There are few ties between dental scholars and those who study drug use, and it can be difficult for dental researchers to find methamphetamine users to study. Whether the drug has a unique effect on dental health has been questioned by a few academics, who note that the long-term use of several other drugs sometimes causes dental problems. Several academic reviews have contradicted this perspective, affirming meth mouth's status as a discrete condition. In favor of its unique status, these reviews cite the differences between methamphetamine-caused caries and those that occur for other reasons, such as
cocaine Cocaine is a tropane alkaloid and central nervous system stimulant, derived primarily from the leaves of two South American coca plants, ''Erythroxylum coca'' and ''Erythroxylum novogranatense, E. novogranatense'', which are cultivated a ...
use, as well as the scope of the tooth decay found in some long-term methamphetamine users. According to the
American Dental Association The American Dental Association (ADA) is an American professional dental association. Established in 1859 and with over 159,000 current members, ADA is the world's largest and oldest national dental association. The organization lobbies on behal ...
, meth mouth "is probably caused by a combination of drug-induced psychological and physiological changes resulting in
xerostomia Xerostomia, also known as dry mouth, is a subjective complaint of dryness in the mouth, which may be associated with a change in the composition of saliva, reduced salivary flow, or have no identifiable cause. This symptom is very common and is o ...
(dry mouth), extended periods of poor
oral hygiene Oral hygiene is the practice of keeping one's oral cavity clean and free of disease and other problems (e.g. bad breath) by regular brushing of the teeth (dental hygiene) and adopting good hygiene habits. It is important that oral hygiene be carr ...
, frequent consumption of high-calorie, carbonated beverages and
bruxism Bruxism is excessive teeth grinding or jaw clenching. It is an oral Parafunctional habit, parafunctional activity; i.e., it is unrelated to normal function such as eating or talking. Bruxism is a common behavior; the global prevalence of brux ...
(teeth grinding and clenching)". As dry mouth is also a common side effect of other stimulants, which are not known to contribute severe tooth decay, many researchers suggest that methamphetamine-associated tooth decay is more due to users' other choices. They suggest the side effect has been exaggerated and stylized to create a stereotype of current users as a deterrence for new ones.


Society and culture

Although most methamphetamine users lived in
Asian countries This is a list of sovereign states and dependent territories in Asia. It includes sovereign state, fully recognized states, states with limited but substantial international recognition, ''de facto'' states with little or no international recogn ...
in the early 2000s, the use of the drug increased dramatically in other parts of the world in that decade. In areas where use of the drug has become common, meth mouth is often widespread. The condition is expensive to treat and has strained public health resources, prompting concerns among dental authorities in several countries about the burden of treatment. Images of meth mouth are usually considered disturbing and have been used in anti-drug campaigns, even being placed on
billboard A billboard (also called a hoarding in the UK and many other parts of the world) is a large outdoor advertising structure (a billing board), typically found in high-traffic areas such as alongside busy roads. Billboards present large advertis ...
s. The condition is often mentioned in media coverage of methamphetamine, and it has been included in media portrayals of drug abuse in order to demonstrate the scope of the drug's effects or to provoke
disgust Disgust (, from Latin , ) is an emotional response of rejection or revulsion to something potentially contagious or something considered offensive, distasteful or unpleasant. In ''The Expression of the Emotions in Man and Animals'', Charles D ...
in the audience. Opponents argue that the term is used to negatively stereotype methamphetamine users, and that it is falsely portrayed as inevitable or characteristic. The drama series ''
Breaking Bad ''Breaking Bad'' is an American crime drama television series created and produced by Vince Gilligan for AMC (TV channel), AMC. Set and filmed in Albuquerque, New Mexico, the series follows Walter White (Breaking Bad), Walter White (Bryan Cran ...
'', which centers around the production of crystal meth, features a number of minor characters who have meth mouth. The series creator
Vince Gilligan George Vincent Gilligan Jr. (born February 10, 1967) is an American screenwriter and filmmaker. He is best known as the creator, primary writer, executive producer, and occasional director of the AMC (TV channel), AMC crime drama series ''Brea ...
has said one of his regrets about the series is that one of the lead characters,
Jesse Pinkman Jesse Bruce Pinkman is a fictional character in the American crime drama television series ''Breaking Bad'', portrayed by Aaron Paul. He is a crystal meth cook and dealer who works with his former high school chemistry teacher, Walter White (p ...
(played by
Aaron Paul Aaron Paul (born Aaron Paul Sturtevant; August 27, 1979) is an American actor. He is best known for portraying Jesse Pinkman in the AMC series ''Breaking Bad'' (2008–2013), for which he won several awards, including three Primetime Emmy ...
), had perfect teeth because he felt this was unrealistic, given the amount of meth the character consumed.


See also

* Faces of Meth


References


Bibliography

Books * * * * Journals * * * * * * * Newspapers * * * * * *


External links


American Dental Association Overview of Meth Mouth
{{Good article Methamphetamine and health Acquired tooth disorders