Mesitol (2,4,6-trimethylphenol) is an
organic compound
In chemistry, organic compounds are generally any chemical compounds that contain carbon- hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. Th ...
with the formula (CH
3)
3C
6H
2OH. It is one of several isomers of
trimethylphenol. The name and structure of mesitol derives from the combination of
mesitylene and
phenol
Phenol (also called carbolic acid) is an aromatic organic compound with the molecular formula . It is a white crystalline solid that is volatile. The molecule consists of a phenyl group () bonded to a hydroxy group (). Mildly acidic, it ...
.
Synthesis
Mesitol is the main product from the methylation of phenol with methanol in the presence of a solid acid.
It can also be obtained by reaction of mesitylene with
peroxymonophosphoric acid:
:

An alternative route involves palladium-catalyzed reaction of bromomesitylene with potassium hydroxide.
References
{{aromatic-stub
Alkylphenols