Meprin A (, ''endopeptidase-2'', ''meprin-a'', ''meprin'', ''N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase'', ''PABA-peptide hydrolase'', ''PPH'') is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
that cleaves protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.
This metalloprotease can be associated with inflammatory responses.
It can be found in the extracellular space where it can also form complex structures by joining its monomers together.
Meprin A is a dimer composed of the products transcribed from the following two genes:
References
EC 3.4.24
Single-pass transmembrane proteins
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