Membrane stabilizing effects involve the inhibition or total abolishing of
action potentials from being propagated across the membrane. This phenomenon is common in nerve tissues as they are the carrier of impulses from the periphery to the
central nervous system. Membrane stabilization is the method through which
local anesthetics work. They block the propagation of action potentials across nerve cells, thereby producing a nerve block.
Some
beta-blockers
Beta blockers, also spelled β-blockers, are a class of medications that are predominantly used to manage abnormal heart rhythms, and to protect the heart from a second heart attack after a first heart attack (secondary prevention). They are al ...
also possess what is referred to as membrane stabilizing activity (MSA). This effect is similar to the membrane stabilizing activity of
sodium channel blockers that represent
Class I antiarrhythmics. MSA agents produced by beta-blockers reduce the increase of cardiac action potential, while also leading to other electrophysiological effects. However, MSA occurs only at very high concentrations and is not of clinical relevance, except after large doses of MSA compounds.
References
Electrophysiology
{{biology-stub