Megaphyllum may refer to:
*
''Megaphyllum'' (millipede), a genus of myriapods in the family Julidae
* ''Megaphyllum'', a genus of flowering plants in the family Rubiaceae; synonym of ''
Pentagonia ''
* ''Megaphyllum'', a genus of cnidarians with unknown classification, described by Soshkina, 1939
{{genus disambiguation