Mauricio Tohen is a Mexican American research psychiatrist, Distinguished Professor, and

Chairman The chair, also chairman, chairwoman, or chairperson, is the presiding officer of an organized group such as a board, committee, or deliberative assembly. The person holding the office, who is typically elected or appointed by members of the gro ...

of the Department of

Psychiatry Psychiatry is the medical specialty devoted to the diagnosis, treatment, and prevention of deleterious mental disorder, mental conditions. These include matters related to cognition, perceptions, Mood (psychology), mood, emotion, and behavior. ...

Behavioral Sciences Behavioural science is the branch of science concerned with human behaviour.Hallsworth, M. (2023). A manifesto for applying behavioural science. ''Nature Human Behaviour'', ''7''(3), 310-322. While the term can technically be applied to the st ...

at the

University of New Mexico The University of New Mexico (UNM; ) is a public research university in Albuquerque, New Mexico, United States. Founded in 1889 by the New Mexico Territorial Legislature, it is the state's second oldest university, a flagship university in th ...

. Tohen's research has focused on the epidemiology, outcome, and treatment of bipolar and psychotic disorders, and is especially known for innovating the design of

clinical trials Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...

and the criteria to determine outcome in such diseases. Tohen has edited several books on his specialties. His social awareness has been noted in the promotion of programs to improve mental health care in areas such as substance abuse, bipolar disorder and schizophrenia.

Education

Tohen graduated as an MD from the

National Autonomous University of Mexico The National Autonomous University of Mexico (, UNAM) is a public university, public research university in Mexico. It has several campuses in Mexico City, and many others in various locations across Mexico, as well as a presence in nine countri ...

, Mexico City in 1976. He trained in Psychiatry at the

University of Toronto The University of Toronto (UToronto or U of T) is a public university, public research university whose main campus is located on the grounds that surround Queen's Park (Toronto), Queen's Park in Toronto, Ontario, Canada. It was founded by ...

where he also obtained a DPsych Diploma in Psychiatric Research (1979–1982). He then pursued a fellowship in

Psychopharmacology Psychopharmacology (from Greek ; ; and ) is the scientific study of the effects drugs have on mood, sensation, thinking, behavior, judgment and evaluation, and memory. It is distinguished from neuropsychopharmacology, which emphasizes ...

(1982–1985) at McLean Hospital,

Harvard Medical School Harvard Medical School (HMS) is the medical school of Harvard University and is located in the Longwood Medical and Academic Area, Longwood Medical Area in Boston, Massachusetts. Founded in 1782, HMS is the third oldest medical school in the Un ...

, followed by a Doctorate in

public health Public health is "the science and art of preventing disease, prolonging life and promoting health through the organized efforts and informed choices of society, organizations, public and private, communities and individuals". Analyzing the de ...

(epidemiology) completed in 1988 at

Harvard School of Public Health The Harvard T.H. Chan School of Public Health is the public health school at Harvard University, located in the Longwood Medical Area of Boston, Massachusetts. It was named after Hong Kong entrepreneur Chan Tseng-hsi in 2014 following a US$350 ...

. In 2000, Tohen also obtained an

MBA A Master of Business Administration (MBA) is a professional degree focused on business administration. The core courses in an MBA program cover various areas of business administration; elective courses may allow further study in a particular a ...

degree from the Kelley School of Business,

Indiana University Indiana University (IU) is a state university system, system of Public university, public universities in the U.S. state of Indiana. The system has two core campuses, five regional campuses, and two regional centers under the administration o ...

Career

Tohen´s career has developed both in academia and industry.

Academia

Tohen spent the first decade of his academic career (1999–2009) at

Harvard Harvard University is a private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher lear ...

where he was 1) Associate Professor of Epidemiology at Harvard School of Public Health, teaching Psychiatric Epidemiology, 2) Clinical Director of the Bipolar and Psychotic Disorders Program at McLean Hospital, conducting research on bipolar disorder and first-episode psychosis, and 3) AssociateProfessor of Psychiatry at Harvard Medical School. Tohen worked at the University of Texas Health Science Center at San Antonio, at the Department of Psychiatry where he occupied positions as Division Head of Mood & Anxiety Disorders, Aaron & Bobbie Elliott Krus Endowed Chair, and tenured Professor. Since 2013, Tohen has been a Professor and Chairman of the Department of Psychiatry & Behavioral Sciences at The University of New Mexico, Health Sciences Center (Albuquerque, NM), where in 2020 he was promoted to the category of Distinguished Professor.

Industry

From 1997 to 2012, Tohen joined Lilly Research Laboratories in Indianapolis, where he reached the position of Distinguished Lilly Scholar. Based on his leadership and clinical trial design, the company obtained the indication for

Olanzapine Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. It is also sometimes used off-label for treatment of chemotherapy-induced nausea and vomitin ...

for the treatment of Acute Mania and relapse prevention from the

FDA The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food ...

and the European CPMP, as well as the indication for bipolar depression for fluoxetine/olanzapine combination from the FDA, and the indication of Olanzapine for acute mania and bipolar depression from the PMDA in Japan.

Research

Tohen has authored over 380 original publications with over 40,000 scientific citations. His most cited papers include: * Hegarty, J. D.; Baldessarini, R. J.; Tohen, M.; Waternaux, C.; Oepen, G. (October 1994). "One hundred years of schizophrenia: a meta-analysis of the outcome literature". ''The American Journal of Psychiatry''. 151 (10): 1409–1416. doi:10.1176/ajp.151.10.1409.

ISSN An International Standard Serial Number (ISSN) is an eight-digit to uniquely identify a periodical publication (periodical), such as a magazine. The ISSN is especially helpful in distinguishing between serials with the same title. ISSNs a ...

0002-953X.

PMID PubMed is an openly accessible, free database which includes primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of ...

8092334. * Tohen, M.; Sanger, T. M.; McElroy, S. L.; Tollefson, G. D.; Chengappa, K. N.; Daniel, D. G.; Petty, F.; Centorrino, F.; Wang, R.; Grundy, S. L.; Greaney, M. G. (May 1999). "Olanzapine versus placebo in the treatment of acute mania. Olanzapine HGEH Study Group". ''The American Journal of Psychiatry''. 156 (5): 702–709. doi:10.1176/ajp.156.5.702.

0002-953X.

10327902. * Tohen, Mauricio; Vieta, Eduard; Calabrese, Joseph; Ketter, Terence A.; Sachs, Gary; Bowden, Charles; Mitchell, Philip B.; Centorrino, Franca; Risser, Richard; Baker, Robert W.; Evans, Angela R. (2003-11). "Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression". ''Archives of General Psychiatry''. 60 (11): 1079–1088. doi:10.1001/archpsyc.60.11.1079.

0003-990X.

14609883 *Tohen, M.; Jacobs, T. G.; Grundy, S. L.; McElroy, S. L.; Banov, M. C.; Janicak, P. G.; Sanger, T.; Risser, R.; Zhang, F.; Toma, V.; Francis, J. (2000-09). "Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzipine HGGW Study Group". ''Archives of General Psychiatry''. 57 (9): 841–849. doi:10.1001/archpsyc.57.9.841.

0003-990X.

10986547

Research topics

Research articles where Tohen is an author will be found in current entries on

Antipsychotic Antipsychotics, previously known as neuroleptics and major tranquilizers, are a class of Psychiatric medication, psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), p ...

, Associated features of bipolar disorder,

Atypical antipsychotic The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neurol ...

Bipolar disorder Bipolar disorder (BD), previously known as manic depression, is a mental disorder characterized by periods of Depression (mood), depression and periods of abnormally elevated Mood (psychology), mood that each last from days to weeks, and in ...

Bipolar I disorder Bipolar I disorder (BD-I; pronounced "type one bipolar disorder") is a type of bipolar spectrum disorder characterized by the occurrence of at least one manic episode, with or without mixed or psychotic features. Most people also, at other ti ...

Cariprazine Cariprazine, sold under the brand name Vraylar among others, is an atypical antipsychotic developed by Gedeon Richter, which is used in the treatment of schizophrenia and bipolar disorder. It is also prescribed as an add-on treatment for bip ...

Clinical trial Clinical trials are prospective biomedical or behavioral research studies on human subject research, human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel v ...

Early intervention in psychosis Early intervention in psychosis is a clinical approach to those experiencing symptoms of psychosis for the first time. It forms part of a new prevention paradigm for psychiatry and is leading to reform of mental health services, especially in the ...

, Lurasidone,

Mental disorder A mental disorder, also referred to as a mental illness, a mental health condition, or a psychiatric disability, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. A mental disorder is ...

, Mixed affective state,

Schizophrenia Schizophrenia () is a mental disorder characterized variously by hallucinations (typically, Auditory hallucination#Schizophrenia, hearing voices), delusions, thought disorder, disorganized thinking and behavior, and Reduced affect display, f ...

, and Treatment of bipolar disorder.

Honors

Tohen has been President of the International Society for Bipolar Disorders (2010–2012) and President of the American Society of Hispanic Psychiatry (2014–2016). In 2016 he was selected by the

National Alliance on Mental Illness The National Alliance on Mental Illness (NAMI) is a United States–based nonprofit organization originally founded as a grassroots group by family members of people diagnosed with mental illness. NAMI identifies its mission as "providing advoca ...

to receive the Exemplary Psychiatrist Award. Also in 2016, the International Society for Bipolar Disorders awarded him the Mogens Schou Award for Education and Teaching. Other honors he has received include a FIRST award from NIMH, the Pope Award from McLean Hospital, a NARSAD Young Investigator Award, and in 2011 the Simon Bolivar Award from the American Psychiatric Association. Tohen was listed by

Thomson Reuters Thomson Reuters Corporation ( ) is a Canadian multinational corporation, multinational content-driven technology Conglomerate (company), conglomerate. The company was founded in Toronto, Ontario, Canada, and maintains its headquarters at 1 ...

among ''The World's Most Influential Scientific Minds 2014'' in Psychiatry/Psychology, based on citation data of scientists who published work with the highest (top 1%) impact in their fields between 2002 and 2013. His Expertise in Bipolar Disorder is ranked by ''Expertscape'' as Top 0.14% worldwide, based on his articles on the topic published from 2010 through 2020.

Books

Tohen has co-edited four books: *Textbook of Psychiatric Epidemiology (1995 first edition, 2002 second edition & 2011 third edition) *Mood Disorders Across the Life Span (1996) *Bipolar Disorder:The Upswing in Research and Treatment (2005) *Bipolar Psychopharmacotherapy: Caring for the Patient, first edition (2006), second edition (2011) He also edited two books: * Bipolar Disorder: Comorbidity in Affective Disorders (1999) *Clinical Trial Design Challenges in Mood Disorders (2015), first edition

References

{{authority control University of Texas Health Science Center at San Antonio faculty University of New Mexico faculty Harvard Medical School faculty National Autonomous University of Mexico alumni University of Toronto alumni Kelley School of Business alumni Harvard T.H. Chan School of Public Health alumni Year of birth missing (living people) Living people