Maud Slye
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Maud Caroline Slye (February 8, 1879 – September 17, 1954) was an American
pathologist Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...
who was born in
Minneapolis Minneapolis is a city in Hennepin County, Minnesota, United States, and its county seat. With a population of 429,954 as of the 2020 United States census, 2020 census, it is the state's List of cities in Minnesota, most populous city. Locat ...
,
Minnesota Minnesota ( ) is a U.S. state, state in the Upper Midwestern region of the United States. It is bordered by the Canadian provinces of Manitoba and Ontario to the north and east and by the U.S. states of Wisconsin to the east, Iowa to the so ...
. A historian of women and science wrote that Slye "'invented' genetically uniform mice as a research tool." Her work focused on the heritability of
cancer Cancer is a group of diseases involving Cell growth#Disorders, abnormal cell growth with the potential to Invasion (cancer), invade or Metastasis, spread to other parts of the body. These contrast with benign tumors, which do not spread. Po ...
in
mice A mouse (: mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus' ...
. She was also an advocate for the comprehensive archiving of human medical records, believing that proper mate selection would help eradicate cancer. During her career, she received multiple awards and honors, including the gold medal of the
American Medical Association The American Medical Association (AMA) is an American professional association and lobbying group of physicians and medical students. This medical association was founded in 1847 and is headquartered in Chicago, Illinois. Membership was 271,660 ...
in 1914, the Ricketts Prize in 1915, and the gold medal of the American Radiological Society in 1922. In 1923, Albert Soiland, a pioneer radiologist, nominated Maud Slye, a cancer pathologist for the
Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, acco ...
. The nomination came as a result of her work as one of the first scientists to suggest that cancer can be an inherited disease, and for the development of new procedures for the care and breeding of lab mice.


Education and career

Slye received her undergraduate training at the
University of Chicago The University of Chicago (UChicago, Chicago, or UChi) is a Private university, private research university in Chicago, Illinois, United States. Its main campus is in the Hyde Park, Chicago, Hyde Park neighborhood on Chicago's South Side, Chic ...
and
Brown University Brown University is a Private university, private Ivy League research university in Providence, Rhode Island, United States. It is the List of colonial colleges, seventh-oldest institution of higher education in the US, founded in 1764 as the ' ...
. While at the University of Chicago, she supported herself as a secretary for University President
William Rainey Harper William Rainey Harper (July 24, 1856 – January 10, 1906) was an American academic leader, an accomplished semiticist, and Baptist clergyman. Harper helped to establish both the University of Chicago and Bradley University and served as the i ...
. After a breakdown, she completed her studies at Brown in 1899. After teaching, she began her postgraduate work in 1908 at the University of Chicago, performing
neurological Neurology (from , "string, nerve" and the suffix -logia, "study of") is the branch of medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the nervous system, which comprises the brain, the s ...
experiments An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into Causality, cause-and-effect by demonstrating what outcome o ...
on mice. She would remain at the University of Chicago for the rest of her career. After hearing of a cluster of
cattle Cattle (''Bos taurus'') are large, domesticated, bovid ungulates widely kept as livestock. They are prominent modern members of the subfamily Bovinae and the most widespread species of the genus '' Bos''. Mature female cattle are calle ...
cancers at a nearby stockyard, she changed the focus of her research to cancer. Slye raised—and kept pedigrees for—150,000 mice during her career. On 5 May 1913, she first presented a paper before the American Society for Cancer Research regarding the work on general problems in heredity, carried on at the University of Chicago in the Department of Zoology. In 1919 she was selected as director of the Cancer Laboratory at the University of Chicago. In 1922, she was promoted to assistant professor and became an associate professor in 1926. She retired in 1945 as a professor
Emeritus ''Emeritus/Emerita'' () is an honorary title granted to someone who retires from a position of distinction, most commonly an academic faculty position, but is allowed to continue using the previous title, as in "professor emeritus". In some c ...
of Pathology. Her belief that cancer was a recessive trait that could be eliminated through breeding caused clashes with fellow scientists, including
C. C. Little Clarence Cook Little (October 6, 1888 – December 22, 1971) was an American genetics, cancer, and tobacco researcher and academic administrator, as well as a proponent of eugenics. Early life C. C. Little was born in Brookline, Massachusetts a ...
. Slye was devoted to her work. A 1937 ''
Time Time is the continuous progression of existence that occurs in an apparently irreversible process, irreversible succession from the past, through the present, and into the future. It is a component quantity of various measurements used to sequ ...
'' account of her behavior at a science convention described her as "high-spirited" and quoted her as saying: "I breed out breast cancers. I don't think we should feel so hopeless about breeding out other types. Only romance stops us. It is the duty of scientists to ascertain and present facts. If the people prefer romance to taking advantage of these facts, there is nothing we can do about it." Reluctant to leave her mice to the care of her assistants, she once went twenty-six years without a vacation. She never married and spent her retirement reviewing data from her research. She died of a
heart attack A myocardial infarction (MI), commonly known as a heart attack, occurs when Ischemia, blood flow decreases or stops in one of the coronary arteries of the heart, causing infarction (tissue death) to the heart muscle. The most common symptom ...
in 1954 and was buried in
Oak Woods Cemetery Oak Woods Cemetery is a large lawn cemetery in Chicago, Illinois, United States. Located at 1035 E. 67th Street, it is in the Greater Grand Crossing area of Chicago's South Side. Established on February 12, 1853, it covers . Oak Woods is th ...
. News of her death was featured on the front page of the ''Chicago Daily Tribune''.


Woman of achievement

The
Women's Centennial Congress The Women's Centennial Congress was organized by Carrie Chapman Catt and held at the Astor Hotel on November 25-27, 1940, to celebrate a century of female progress. History The date chosen was 100 years after the first World Anti-Slavery Conven ...
organized by
Carrie Chapman Catt Carrie Chapman Catt (born Carrie Clinton Lane; January 9, 1859#Fowler, Fowler, p. 3 – March 9, 1947) was an American women's suffrage leader who campaigned for the Nineteenth Amendment to the United States Constitution, which gave U.S. women t ...
was held in New York City in November 25–27, 1940, to celebrate a century of female progress. To demonstrate their advances, 100 "successful women" were invited to represent their respective fields of study in which they were working in 1940, but that would have been impossible for them in 1840. Slye's participation was listed under "Science" with
Margaret Mead Margaret Mead (December 16, 1901 – November 15, 1978) was an American cultural anthropologist, author and speaker, who appeared frequently in the mass media during the 1960s and the 1970s. She earned her bachelor's degree at Barnard Col ...
and
Annie Jump Cannon Annie Jump Cannon (; December 11, 1863 – April 13, 1941) was an American astronomer whose cataloging work was instrumental in the development of contemporary stellar classification. With Edward C. Pickering, she is credited with the creation of ...
, among others. The 100 women chosen were "all American, alive and doing jobs that would have been impossible for a woman to undertake in 1840."


Poet

Besides a prolific and dedicated scientist, Slye found time to publish two separate volumes of poetry. ''Songs and Solaces'' (1934) and ''I in the Wind'' (1936). *''Songs and Solaces'', 1934. *''I in the Wind, Symphony no. 1, and minor songs'', 1936.Slye, Maud. Cuts by Maud Henrichs. (1936). ''I in the Wind, Symphony no. 1, and minor songs''. The Stratford Company. Boston, Massachusetts. 397 pages.


References


External links


Picture of Slye in 1936 Modern Mechanix magazine

Guide to the Maud Slye Papers 1910s-1930s
at th
University of Chicago Special Collections Research Center
{{DEFAULTSORT:Slye, Maud 1879 births 1954 deaths Scientists from Minneapolis University of Chicago alumni Brown University alumni American pathologists University of Chicago faculty American women scientists American cancer researchers American women poets 20th-century American poets 20th-century American women writers American women academics Biologists from Minnesota Graduate Women in Science members