Matthew Edward Hurles (born 1974) is a British scientist who is director of the

Wellcome Sanger Institute The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit organisation, non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust. It is l ...

and an

honorary professor Honorary titles (professor, president, reader, lecturer) in academia may be conferred on persons in recognition of contributions by a non-employee or by an employee beyond regular duties. This practice primarily exists in the UK and Germany, as ...

of Human Genetics and

Genomics Genomics is an interdisciplinary field of molecular biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, ...

at the

University of Cambridge The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, wo ...

Education

Hurles was privately educated at

Hampton School Hampton School is a fee-charging, boys-only private day school in Hampton, London, England. As of the 2024–2025 academic year, the school charges a minimum of £26,040 per year for attendance. Until 1975, the school was a voluntary aided gram ...

and the

University of Oxford The University of Oxford is a collegiate university, collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the List of oldest un ...

where he was awarded a

Bachelor of Arts A Bachelor of Arts (abbreviated B.A., BA, A.B. or AB; from the Latin ', ', or ') is the holder of a bachelor's degree awarded for an undergraduate program in the liberal arts, or, in some cases, other disciplines. A Bachelor of Arts deg ...

degree in

Biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

. He completed his

PhD A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

in 1999 on the

genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinians, Augustinian ...

of the

Y chromosome The Y chromosome is one of two sex chromosomes in therian mammals and other organisms. Along with the X chromosome, it is part of the XY sex-determination system, in which the Y is the sex-determining chromosome because the presence of the ...

at the

University of Leicester The University of Leicester ( ) is a public university, public research university based in Leicester, England. The main campus is south of the city centre, adjacent to Victoria Park, Leicester, Victoria Park. The university's predecessor, Univ ...

supervised by Mark Jobling

Research and career

Hurles research investigates the causes and consequences of new

mutation In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, ...

s as

DNA Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...

is passed from one generation to the next. He is best known for his work on characterizing the extent and impact of

structural variation Genomic structural variation is the variation in structure of an organism's chromosome, such as deletions, duplications, copy-number variants, insertions, inversions and translocations. Originally, a structure variation affects a sequence length a ...

in the

human genome The human genome is a complete set of nucleic acid sequences for humans, encoded as the DNA within each of the 23 distinct chromosomes in the cell nucleus. A small DNA molecule is found within individual Mitochondrial DNA, mitochondria. These ar ...

and on deciphering the genetic architecture of severe

neurodevelopmental disorder Neurodevelopmental disorders are a group of mental conditions negatively affecting the development of the nervous system, which includes the brain and spinal cord. According to the American Psychiatric Association Diagnostic and Statistical Manu ...

s. Hurles group has used large-scale genomic studies to highlight the predominant role that new mutations of many different types play in causing diverse developmental disorders and has led to the discovery of tens of previously unrecognised

genetic disease A genetic disorder is a health problem caused by one or more abnormalities in the genome. It can be caused by a mutation in a single gene (monogenic) or multiple genes (polygenic) or by a chromosome abnormality. Although polygenic disorders are ...

Awards and honours

Hurles was elected a Fellow of the Royal Society (FRS) in 2019. One or more of the preceding sentences incorporates text from the royalsociety.org website where: He is also a

Fellow of the Academy of Medical Sciences Fellowship of the Academy of Medical Sciences (FMedSci) is an award for medical scientists who are judged by the UK Academy of Medical Sciences for the "excellence of their science, their contribution to medicine and society and the range of the ...

(FMedSci) and was awarded the Crick Medal and Lecture in 2013.

References

{{DEFAULTSORT:Hurles, Matthew Fellows of the Royal Society People educated at Hampton School Fellows of the Academy of Medical Sciences (United Kingdom) Living people 1974 births Alumni of the University of Oxford