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Matthew Dobson (1732–1784) was an English physician and experimental
physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a subdiscipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out chemical and ...
. He is now remembered for his work on
diabetes Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or the cells of th ...
.


Life and career

His parents were Joshua Dobson, a nonconformist minister at Lydgate,
West Yorkshire West Yorkshire is a Metropolitan counties of England, metropolitan and Ceremonial counties of England, ceremonial county in the Yorkshire and the Humber region of England. It borders North Yorkshire to the north and east, South Yorkshire and De ...
, and Elizabeth, daughter of Matthew Smith who was minister at Mixenden. He matriculated at
Glasgow University The University of Glasgow (abbreviated as ''Glas.'' in post-nominals; ) is a public research university in Glasgow, Scotland. Founded by papal bull in , it is the fourth-oldest university in the English-speaking world and one of Scotland's four ...
in 1750, where he graduated MA in 1753. He then moved to
Edinburgh University The University of Edinburgh (, ; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Founded by the town council under the authority of a royal charter from King James VI in 1582 and offi ...
, where he graduated MD in 1756. From the end of the decade he worked as a doctor in
Liverpool Liverpool is a port City status in the United Kingdom, city and metropolitan borough in Merseyside, England. It is situated on the eastern side of the River Mersey, Mersey Estuary, near the Irish Sea, north-west of London. With a population ...
. Dobson worked with Matthew Turner and others to set up the Liverpool Academy of Art in 1769, a local reply to the
Royal Academy The Royal Academy of Arts (RA) is an art institution based in Burlington House in Piccadilly London, England. Founded in 1768, it has a unique position as an independent, privately funded institution led by eminent artists and architects. Its ...
's foundation in 1768. After a slow start, a first exhibition was held in 1774. (The 1810 foundation of the
Liverpool Academy of Arts The Liverpool Academy of Arts was founded in Liverpool in April 1810 as a regional equivalent of the Royal Academy, London. It followed the Liverpool Society of Artists, first founded in 1769, which had a fitful existence until 1794. Two local a ...
was in the nature of a fresh beginning.) In 1770, he was appointed physician to
Liverpool Infirmary The Liverpool Royal Infirmary was a hospital in Pembroke Place in Liverpool, England. The building is now used by the University of Liverpool. History The infirmary has its origins in a small building on Shaw's Brow which was opened by the Edward ...
, as successor to John Kennion. He had a house in Harrington Street. When
William Enfield William Enfield (29 March 1741 – 3 November 1797) was a British Unitarian minister who published a bestselling book on elocution entitled ''The Speaker'' (1774). Life Enfield was born in Sudbury, Suffolk to William and Ann Enfield. In 1758, h ...
wrote his ''History of Leverpool'' (1772), Dobson contributed to it.
James Allanson Picton James Allanson Picton (8 August 1832 – 4 February 1910) was a British independent minister, author, philosopher and Liberal politician. Picton promoted a philosophy known as Christian pantheism. Life Picton was born at Liverpool, the eldes ...
, ''Memorials of Liverpool: historical and topographical, including a history of the Dock Estate'' vol. 2 (1875), pp. 132–133
archive.org.
/ref> About 1776 Dobson gave up his Liverpool practice, which was taken over by
Joseph Brandreth Joseph Brandreth M.D. (1745 – 10 April 1815) was an 18th-century English medical practitioner, who served as Physician to the Duke of Gloucester. He was born at Ormskirk, Lancashire, in 1745. After taking a doctorate of Medicine at Edinburgh ...
. He was elected a
Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...
in 1778, and became head of the Liverpool Medical Library in 1779. In 1780, suffering from poor health, he retired to
Bath, Somerset Bath (Received Pronunciation, RP: , ) is a city in Somerset, England, known for and named after its Roman Baths (Bath), Roman-built baths. At the 2021 census, the population was 94,092. Bath is in the valley of the River Avon, Bristol, River A ...
. He joined the
Manchester Literary and Philosophical Society The Manchester Literary and Philosophical Society, popularly known as the Lit. & Phil., is one of the oldest learned societies in the United Kingdom and second oldest provincial learned society (after the Spalding Gentlemen's Society). Promi ...
, established in 1781. Dobson was physician, and eventually confidant to
Hester Thrale Hester Lynch Thrale Piozzi (née Salusbury; 27 January 1741 or 16 January 1740 – 2 May 1821)Contemporary records, which used the Julian calendar and the Annunciation Style of enumerating years, recorded her birth as 16 January 1740. The pro ...
. He played a key role in her second marriage to Gabriel Piozzi, persuading her daughter Queeney to accept Piozzi, whose banishment from the household he said was life-threatening for her mother. Dobson died in Bath on 25 July 1784, incidentally on the day of Hester Thrale's second marriage, and was buried at Walcot. A memorial was put up in Toxteth Park chapel.


Study group

Dobson was part of a medical study group for his local area that met on a quarterly basis.
John Aikin John Aikin (15 January 1747 – 7 December 1822) was an English medical doctor and surgeon. Later in life he devoted himself wholly to biography and writing in periodicals. Life He was born at Kibworth Harcourt, Leicestershire, England, son of ...
of Chester and Warrington took part, with
John Bostock John Joseph Bostock (born 15 January 1992) is an English professional footballer who plays as a midfielder for club Solihull Moors. Bostock made his professional debut for Crystal Palace at the age of 15. In 2008, he signed for Tottenham H ...
,
Thomas Percival Thomas Percival (29 September 1740 – 30 August 1804) was an English physician, health reformer, ethicist and author who wrote an early code of medical ethics. He drew up a pamphlet with the code in 1794 and wrote an expanded version in 180 ...
and
John Haygarth John Haygarth FRS FRSE (1740 – 10 June 1827) was an 18th-century British physician who discovered new ways to prevent the spread of fever among patients and reduce the mortality rate of smallpox. Life Haygarth was born to William Haygarth a ...
. Dobson provided information on
influenza Influenza, commonly known as the flu, is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These sympto ...
in Liverpool for the researches of Haygarth, a classmate from Edinburgh. This group was closely associated with
Joseph Priestley Joseph Priestley (; 24 March 1733 – 6 February 1804) was an English chemist, Unitarian, Natural philosophy, natural philosopher, English Separatist, separatist theologian, Linguist, grammarian, multi-subject educator and Classical libera ...
,
Richard Price Richard Price (23 February 1723 – 19 April 1791) was a British moral philosopher, Nonconformist minister and mathematician. He was also a political reformer and pamphleteer, active in radical, republican, and liberal causes such as the F ...
and radical politics. It also cooperated as part of Priestley's attempt to develop "pneumatic therapy": the medical use of newly isolated gases.


Medical work

In his student days, Dobson worked with
William Cullen William Cullen (; 15 April 17105 February 1790) was a British physician, chemist and agriculturalist from Hamilton, Scotland, who also served as a professor at the Edinburgh Medical School. Cullen was a central figure in the Scottish Enli ...
at
Glasgow University The University of Glasgow (abbreviated as ''Glas.'' in post-nominals; ) is a public research university in Glasgow, Scotland. Founded by papal bull in , it is the fourth-oldest university in the English-speaking world and one of Scotland's four ...
on
evaporation Evaporation is a type of vaporization that occurs on the Interface (chemistry), surface of a liquid as it changes into the gas phase. A high concentration of the evaporating substance in the surrounding gas significantly slows down evapora ...
. In 1775, Dobson for the first time identified as a sugar the sweet substance in the
urine Urine is a liquid by-product of metabolism in humans and many other animals. In placental mammals, urine flows from the Kidney (vertebrates), kidneys through the ureters to the urinary bladder and exits the urethra through the penile meatus (mal ...
of patients with
diabetes Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or the cells of th ...
. He published his work as ''Experiments and Observations on the Urine in Diabetics'' (1776). It did not have a major clinical impact, the findings being still debated until the work of
George Owen Rees George Owen Rees (November 1813 – 27 May 1889) was a Welsh-Italian physician. Life Born at Smyrna in November 1813, he was son of Josiah Rees, a Levantine merchant and British consul there. His mother was born in Newfoundland, Canada. Thomas ...
in the middle of the 19th century. Dobson observed the sweet taste of the blood of diabetics (caused by
hyperglycemia Hyperglycemia is a condition where unusually high amount of glucose is present in blood. It is defined as blood glucose level exceeding 6.9 mmol/L (125 mg/dL) after fasting for 8 hours or 10 mmol/L (180 mg/dL) 2 hours after eating. Blood gluc ...
), and argued that the disease was not located in the
kidneys In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation. They are located on the left and right in the retro ...
, as was believed at the time. Initial use of specialised diets by physicians was not very successful.
John Rollo John Rollo M.D. (d. December 23, 1809) was a Scottish military surgeon, now known for his work on a diabetic diet. Rollo was the first to suggest a low-carbohydrate diet as a treatment for diabetes.Veves, Aristidis; Malik, Rayaz A. (2007). ''Diab ...
cited Dobson in his research of the late 1790s, and established principles for a
diabetic diet A diabetic diet is a Diet (nutrition), diet that is used by people with diabetes mellitus or high blood sugar to minimize symptoms and dangerous complications of long-term elevations in blood sugar (i.e.: cardiovascular disease, Diabetic nephrop ...
. In 1775, Dobson experimented with a heated room as treatment, a line of research already explored by
George Fordyce George Fordyce (18 November 1736 – 25 May 1802) was a Scottish physician, lecturer on medicine, and chemist, who was a Fellow of the Royal Society and a Fellow of the Royal College of Physicians. Early life George Fordyce was born at Aberde ...
and
Charles Blagden Sir Charles Brian Blagden Fellow of the Royal Society, FRS (17 April 1748 – 26 March 1820) was an English physician and chemist. He served as a medical officer in the Army (1776–1780) and later held the position of Secretary of the Royal S ...
. His colleague
Henry Park Henry Park (2 March 1744–5 – 28 January 1831) was an English surgeon. Biography Park was the son of a Liverpool surgeon, was born in that town on 2 March 1744–5, and received his early education under the Rev. Henry Wolstenholme. At fourte ...
acted as guinea pig. He published the results as a letter to John Fothergill in ''
Philosophical Transactions ''Philosophical Transactions of the Royal Society'' is a scientific journal published by the Royal Society. In its earliest days, it was a private venture of the Royal Society's secretary. It was established in 1665, making it the second journ ...
''. In 1779, Dobson reported success in using "fixed air" (
carbon dioxide Carbon dioxide is a chemical compound with the chemical formula . It is made up of molecules that each have one carbon atom covalent bond, covalently double bonded to two oxygen atoms. It is found in a gas state at room temperature and at norma ...
) in the treatment of
scurvy Scurvy is a deficiency disease (state of malnutrition) resulting from a lack of vitamin C (ascorbic acid). Early symptoms of deficiency include weakness, fatigue, and sore arms and legs. Without treatment, anemia, decreased red blood cells, gum d ...
. That year he published ''Medical Commentary on Fixed Air''. The 1787 edition had an appendix by William Falconer. The work also advocated fixed air as a treatment for the stone. Dobson was interested in
bladder stone A bladder stone is a stone found in the urinary bladder. Signs and symptoms Bladder stones are small mineral deposits that can form in the bladder. In most cases bladder stones develop when the urine becomes very concentrated or when one is ...
s from a statistical point of view, too, and gathered data from
Norwich Hospital The Norwich State Hospital, originally established as the Norwich State Hospital for the Insane, later shortened to the Norwich Hospital, was a psychiatric hospital located in Preston, Connecticut, Preston and Norwich, Connecticut. It opened i ...
. In fact he made a wider survey of hospitals and their admissions in the 1779 edition, Norwich having the highest proportion of admitted patients for bladder stone. The figures were reprinted by Leonhard Ludwig Finke during the 1790s.A. Batty Shaw, ''The Norwich School of Lithotomy'' (PDF)
at pp. 236–237.


Family

In 1759, Dobson married
Susannah Dobson Susannah Dobson née Dawson (c. 1742Temma Berg: ''The Lives and Letters of an Eighteenth-Century Circle of Acquaintance'' (Aldershot, UK, and Burlington, VT: Ashgate, 2006)Retrieved 19 May 2017 p. 56. – 29 September 1795) was a translator from ...
(née Dawson), a translator from French. They had three children, at least two of whom were baptised at the
Octagon Chapel, Liverpool The Octagon Chapel, Liverpool, was a nonconformist church in Liverpool, England, opened in 1763. It was founded by local congregations, those of Benn's Garden and Kaye Street chapels. The aim was to use a non-sectarian liturgy; Thomas Bentley ...
. Dobson was an associate of
Thomas Bentley Thomas Bentley may refer to: * Thomas Bentley (director) Thomas Bentley (23 February 1884 – 23 December 1966) was a British film director. He directed 68 films between 1912 and 1941. He directed three films in the early DeForest Phonofilm sou ...
in the construction of the chapel; and Nicholas Clayton, a classmate from Glasgow, was the first minister.


Notes

{{DEFAULTSORT:Dobson, Matthew 1732 births 1784 deaths 18th-century English medical doctors English physiologists Fellows of the Royal Society