Matriptases () are an
enzyme family.
This enzyme cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position
This
trypsin-like
integral-membrane serine
Serine (symbol Ser or S) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated − form under biological conditions), a carboxyl group (which is in the deprotonated − form un ...
peptidase has been implicated in
breast cancer invasion and
metastasis. It belongs to
proteases of PA superfamily.
Human matriptases
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ST14
Suppressor of tumorigenicity 14 protein, also known as matriptase, is a protein that in humans is encoded by the ST14 gene. ST14 orthologs have been identified in most mammals for which complete genome data are available.
Function
Matriptase ...
, also known as matriptase
*
TMPRSS6, also known as matriptase 2
References
External links
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EC 3.4.21