Marsicano is a surname. Notable people with the surname include:
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Alberto Marsicano (1952–2013), Brazilian musician, translator, writer, philosopher and professor
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Michael Marsicano (born 1956), American entrepreneur, President and CEO of Foundation For The Carolinas
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Nicholas Marsicano (1908–1991), American painter and university teacher
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Trevor Marsicano (born 1989), American speed skater and Olympian
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Claudia Marsicano (born 1992), Italian actress
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