Markus J. Buehler

Markus J. Buehler is an American materials scientist and engineer at the Massachusetts Institute of Technology (MIT), where he holds the endowed McAfee Professorship of Engineering chair. He is a member of the faculty at MIT's Department of Civil and Environmental Engineering and Mechanical Engineering, where he directs the Laboratory for Atomistic and Molecular Mechanics (LAMM),. He is a member of MIT's Center for Computational Science and Engineering (CCSE) in the Schwarzman College of Computing. He is a pioneer in AI for science and engineering. He created powerful graph‑aware, multi‑agent AI models that turn heterogeneous data into science-grounded actionable insight, powering breakthroughs in materials science, biology and healthcare. His work on AI-driven knowledge discovery and graph reasoning demonstrated the utilization of machine intelligence to further scientific breakthroughs with applications in nanotechnology, advanced materials, and protein science.

His scholarship spans science to art, and he is also a composer of experimental, classical and electronic music, with an interest in sonification. He has given several TED talks about his work.

Between 2013 and 2020, he served as the head of the Department of Civil and Environmental Engineering at MIT. His research and teaching activities center on the application of a computational materials science approach to understand functional material properties in biological and synthetic materials, specifically focused on mechanical properties and nano-engineering of multiscale materials.

His work incorporates materials science, engineering, mathematics and the establishment of links between natural materials with the arts through the use of category theory.

Working at the interface of art and science, he is also a composer of music with an interest in sonification, whereby he developed a method to translate material structure into musical form and vice versa, realizing a materialization of sonic information in biomaterials protein design. He developed the materiomusical compositional technique.

In 2020, he set the pathogen of COVID-19 to music, exemplifying a relationship between art and science.

Education and career

Before joining MIT in 2005, he served as the director of multiscale modeling and software integration at Caltech’s Materials and Process Simulation Center in the Division of Chemistry and Chemical Engineering. He received a Ph.D. in chemistry from the University of Stuttgart and the Max Planck Institute for Metals Research after obtaining an M.S. in Engineering Mechanics from Michigan Tech, and undergraduate studies in Chemical and Process Engineering at the University of Stuttgart.

Research

Buehler has a background in materials science, engineering science, applied mechanics and computational science. Buehler's research focuses on bottom-up simulation of structural and mechanical properties of biological, bioinspired and synthetic materials across multiple scales, with a specific focus on materials failure from a nanoscale and molecular perspective, and on developing a fundamental understanding of how functional material properties are created in natural, biological and synthetic materials, including agentic AI and graph-based reasoning models. He is best known for the use of simple computational models to explain complex materials phenomena in biology and engineering from a bottom-up perspective. His work on 3D printing explores the integrated computational-experimental design of novel materials, including the use of AI and AR/VR, and immersive modeling.

His recent work has focused on applying a computational materials science approach to study materials failure in biological systems, including the investigation of material breakdown in a variety of diseases and other extreme conditions across multiple time- and length-scales. His key contributions lie in the field of deformation and failure of structural protein materials such as collagen and silk, where his work revealed universal material design paradigms that enable protein materials to provide enhanced and diverse functionality despite limited resources (energy, material volume, weak building blocks such as H-bonds, etc.), and demonstrated how these mechanisms break down under extreme conditions and disease (impact, trauma, mutations, flaws, etc.).

The impact of his work has been the establishment of the universality-diversity paradigm, explaining how multifunctionality (diversity) of material properties in biology is achieved by changing structural arrangements of few (universal) constituents rather than inventing new building blocks, or through reliance of the quality of building blocks. Some of Buehler's current work involves the use of ologs, a category-theoretic framework for knowledge representation, to encode the structure-function relationships inherent in hierarchical materials.

Buehler has published more than 500 articles, with more than 55,000 citations, on theoretical and computational modeling of materials using various types of simulation methods, a monograph on atomistic modeling, a book on Biomateriomics, several book chapters, and has given hundreds of invited lectures, keynote talks and plenary speeches around the world. His work is published in peer-reviewed scientific journals such as ''Nature'', ''Nature Materials'', ''PNAS'', ''Science Advances'', ''Advanced Materials'', ''Royal Society Interface'', and many others.

In a recent Stanford University study, he has been named as one of the world's highly ranked researchers in 2020, within the top 0.09% of all researchers in the nanoscience category. He collaborates broadly with experimental researchers in the United States, Europe and Asia. He serves as a PI and co-PI on numerous research grants, including several interdisciplinary research projects funded by the National Science Foundation, Department of Defense, National Institutes of Health (NIH), and many other organizations as well as industrial partners.

Teaching

His teaching at MIT focus on engineering mechanics and modeling and simulation, and on introducing undergraduate and graduate students to computational research. He teaches professional educational courses in areas of materials design, machine learning, and additive manufacturing. Since 2020 he has been teaching a course on Machine Learning for Materials Informatics, targeting AI-driven upskilling.

He has been involved in teaching MIT subjects 3.021J Introduction to Modeling and Simulation, 1.978 From nano to macro: Introduction to atomistic modeling techniques, 1.545 Atomistic Modeling of Materials and Structures, 1.050 Engineering Mechanics I, and 2.174J: Advancing Mechanics and Materials via Machine Learning. Buehler collaborates with MIT's IS&T department within the scope of the initiative "Bringing Research Tools into the Classroom", where is developing tools to enable simple use of multiscale simulation tools in teaching and education of undergraduate and graduate students. He is also actively participating in MIT's Undergraduate Research Opportunities Program (UROP), where he serves as a faculty mentor. He is a faculty advisor in the MIT Summer Research Program and served as faculty advisor of the Everett Moore Baker Memorial Foundation.

He is the author of the textbooks ''Atomistic Modeling of Materials Failure'' and ''Biomateriomics''. The former text focuses the mechanical properties of materials and the connections between atomistic and continuum theories while the latter is aimed at discussing hierarchical and motif structures in biological materials.

Service

Buehler serves as editor or a member of the editorial board of several international journals including APL Machine Learning, PLoS ONE, International Journal of Applied Mechanics, Biophysical Journal, Journal of the Mechanical Behavior of Biomedical Materials, Journal of Engineering Mechanics, Journal of Nanomechanics and Micromechanics, and the Journal of Computational and Theoretical Nanoscience. Since 2011 he serves as a co-Editor in Chief of BioNanoScience, a journal he co-founded. He was elected to the editorial board of the Journal of the Royal Society Interface in 2012.

He is the former chair of the Biomechanics Committee at the Engineering Mechanics Institute of the ASCE, co-chair of the NanoEngineering in Medicine and Biology Steering Committee at the ASME, a member of the U.S. National Committee on Biomechanics, and participates in several other committees at ASME, including the Committee on Mechanics in Biology and Medicine. He is also active in the Materials Research Society as volunteer writer for the ''MRS Bulletin'', organizer of MRS symposiums, and through his involvement in the MRS Graduate Student Award program. Since 2010 he serves as the director of the MIT-Germany Program (MISTI Germany). He is the editor-in-chief of the ''Journal of the Mechanical Behavior of Biomedical Materials''.

Awards and recognitions

Buehler received the National Science Foundation CAREER Award, the United States Air Force Young Investigator Award, the Navy Young Investigator Award, and the DARPA Young Faculty Award. Buehler was invited to the National Academy of Engineering-Frontiers in Engineering symposium of the National Academy of Engineering. In 2023, he was elected to the National Academy of Engineering. In 2009, his work was recognized by the Presidential Early Career Award for Scientists and Engineers (PECASE). He received the 2010 Harold E. Edgerton Faculty Achievement Award, the 2010 ASME Sia Nemat-Nasser Award, the 2011 Thomas J.R. Hughes Young Investigator Award and the 2011 Rossiter W. Raymond Memorial Award. In 2011 he received the inaugural Leonardo da Vinci Award from EMI. His work was recognized with several other awards including the Alfred Noble Prize. In 2021, he received the ASME Drucker Medal. In 2025, he received the Washington Award. Buehler was elected to the National Academy of Engineering in 2023.

References

General references

List of publications at LAMMNPR story on 3D printing and spider websForbes Magazine article on protein designScience Careers: Winning Strategies: Advice from PECASE WinnersThere’s a symphony in the antibody protein the body makes to neutralize the coronavirusUnraveling silks’ secretsMIT probes secret to bone's strengthNBC article on mussel-inspired building designsWall Street Journal article on coronavirus work
* ttp://web.mit.edu/newsoffice/2006/collagen.html Math model may help to study collagen ailmentsbr>Classic FM radio station article & broadcast
* ttps://news.mit.edu/2015/buehler-named-mcafee-professor-1112 Buehler appointed to the Institute-wider endowed chair professorship at MITbr>Speed plays crucial role in breaking protein's H-bondsS. Cranford, M. Buehler, Materiomics: biological protein materials, from nano to macro, Nanotechnology, Science and Applications, Vol. 3, pp. 127–148, 2010.M.J. Buehler, Tu(r)ning weakness to strength, Nano Today, Vol. 5(5), pp. 379–383, 2010.Buehler to receive inaugural Leonardo da Vinci AwardResearchers link patterns seen in spider silk, melodiesThe Beethoven connection
* ttp://news.mit.edu/2019/spider-web-music-inspiring-harmony-art-and-science-0108 Spider web music: An inspiring harmony of art and sciencebr>Spider web music: Translating proteins into music, and backMateriomusic: Setting coronavirus and AI inspired proteins to music

External links

Laboratory for Atomistic and Molecular Mechanics
at MIT
website
at MIT
Group members of the Laboratory for Atomistic and Molecular Mechanics
at MIT
Publications
at LAMM
LAMM Twitter site
for news and announcements
Markus Buehler Twitter siteMarkus Buehler Instagram sitePortfolio of materiomusical work
at MIT

Google Scholar

{{DEFAULTSORT:Buehler, Markus J.
Living people
MIT School of Engineering faculty
21st-century American engineers
21st-century American scientists
American nanotechnologists
American scientists
American materials scientists
American composers
1977 births
Michigan Technological University alumni
California Institute of Technology alumni
Members of the United States National Academy of Engineering
Recipients of the Presidential Early Career Award for Scientists and Engineers