Mark S. Cohen
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Mark Steven Cohen (born 1956) is an American
neuroscientist A neuroscientist (or neurobiologist) is a scientist specializing in neuroscience that deals with the anatomy and function of neurons, Biological neural network, neural circuits, and glia, and their Behavior, behavioral, biological, and psycholo ...
and early pioneer of functional brain imaging using
magnetic resonance imaging Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to generate pictures of the anatomy and the physiological processes inside the body. MRI scanners use strong magnetic fields, magnetic field gradients, and ...
. He is a currently a professor of
psychiatry Psychiatry is the medical specialty devoted to the diagnosis, treatment, and prevention of deleterious mental disorder, mental conditions. These include matters related to cognition, perceptions, Mood (psychology), mood, emotion, and behavior. ...
,
neurology Neurology (from , "string, nerve" and the suffix wikt:-logia, -logia, "study of") is the branch of specialty (medicine) , medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the nervous syst ...
,
radiology Radiology ( ) is the medical specialty that uses medical imaging to diagnose diseases and guide treatment within the bodies of humans and other animals. It began with radiography (which is why its name has a root referring to radiation), but tod ...
, psychology, biomedical physics, and
biomedical engineering Biomedical engineering (BME) or medical engineering is the application of engineering principles and design concepts to medicine and biology for healthcare applications (e.g., diagnostic or therapeutic purposes). BME also integrates the logica ...
at the
Semel Institute for Neuroscience and Human Behavior The Semel Institute for Neuroscience and Human Behavior is a research institute of the University of California Los Angeles (UCLA). It includes a number of centers, including the "Center for Neurobehavioral Genetics", which uses DNA sequencing, ...
and the Staglin Center for
Cognitive Neuroscience Cognitive neuroscience is the scientific field that is concerned with the study of the Biology, biological processes and aspects that underlie cognition, with a specific focus on the neural connections in the brain which are involved in mental ...
. He is also a performing musician.


Biography

Cohen was born in St. Paul, Minnesota. He was raised in Stanford, California. In 1974, Cohen began his undergraduate studies in engineering at the
Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a Private university, private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of moder ...
before transferring to
Stanford University Leland Stanford Junior University, commonly referred to as Stanford University, is a Private university, private research university in Stanford, California, United States. It was founded in 1885 by railroad magnate Leland Stanford (the eighth ...
in 1976, where he received his A.B. degree in human biology in 1979.Curriculum Vitea Mark S. Cohen, Ph.D.
- website of the UCLA Department of Psychology
He then went to the
Rockefeller University The Rockefeller University is a Private university, private Medical research, biomedical Research university, research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and pro ...
, where he trained under Victor Wilson, Donald Pfaff, and Susan Schwartz Giblin, receiving his
Ph.D. A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...
in 1985 for his work on the pudendal nerve evoked response and its modulation by steroid hormones. In 1985 Cohen joined the MRI Applications Group at Siemens Medical Solutions where he began a career in MRI that was focused originally on education and on technological improvements to reduce scan times. From 1988 to 1990 he directed the applications program at Advanced NMR Systems in Woburn Massachusetts, a small startup dedicated to the creation of a practical echo planar imaging instrument. He joined the faculty at Harvard Massachusetts General Hospital in 1990, where he directed the "Hyperscan" fast imaging laboratory and was the director of the MRI education program until 1993. In 1993 Cohen joined the faculty at
UCLA The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California, United States. Its academic roots were established in 1881 as a normal school then known as the southern branch of the C ...
, holding professorships in
Psychiatry Psychiatry is the medical specialty devoted to the diagnosis, treatment, and prevention of deleterious mental disorder, mental conditions. These include matters related to cognition, perceptions, Mood (psychology), mood, emotion, and behavior. ...
,
Neurology Neurology (from , "string, nerve" and the suffix wikt:-logia, -logia, "study of") is the branch of specialty (medicine) , medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the nervous syst ...
,
Radiology Radiology ( ) is the medical specialty that uses medical imaging to diagnose diseases and guide treatment within the bodies of humans and other animals. It began with radiography (which is why its name has a root referring to radiation), but tod ...
, Biomedical Physics,
Psychology Psychology is the scientific study of mind and behavior. Its subject matter includes the behavior of humans and nonhumans, both consciousness, conscious and Unconscious mind, unconscious phenomena, and mental processes such as thoughts, feel ...
and
Bioengineering Biological engineering or bioengineering is the application of principles of biology and the tools of engineering to create usable, tangible, economically viable products. Biological engineering employs knowledge and expertise from a number ...
. He served on the UCLA Council for Research from 2011 to 2016 and as its chair for two years. In 2005 Cohen established th
UCLA/Semel Neuroimaging Training Program (NITP)
funded by
NIH The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is part of the United States Department of Health and Human Service ...
, and he directed the program for ten years. The NITP, which provided stipend support for both US and International students, provided core training in statistics, analog and digital signal processing, computation, electronics, neurophysiology, and a range of imaging methods. NITP summer training sessions provided immersive training in advanced MRI methods for more than 350 attendees and were simulcasted to more than 2,000 viewers in more than 160 countries. The NITP was profiled in bot
Science
an
Nature
magazines.


Educator

Cohen served as the Chair of the Education Committee for the Society of Magnetic Resonance and the Chair of the Education Committee for the Society of Magnetic Resonance in Medicine. He received both a Post-Doctoral Mentoring Award and an Excellence in (undergraduate) Mentoring Award from UCLA. He also was given th
Education in Neuroimaging Award
from the
Organization for Human Brain Mapping The Organization for Human Brain Mapping (OHBM) is an organization of scientists with the main aim of organizing an annual meeting ("Annual Meeting of the Organization for Human Brain Mapping"). The organization was established in 1995 at its fir ...
. He mentored a total of 40 doctoral students at
UCLA The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California, United States. Its academic roots were established in 1881 as a normal school then known as the southern branch of the C ...
,
UC Santa Barbara The University of California, Santa Barbara (UC Santa Barbara or UCSB) is a public land-grant research university in Santa Barbara County, California, United States. Tracing its roots back to 1891 as an independent teachers college, UCSB joined ...
, Cal Tech, and the
University of Southern California The University of Southern California (USC, SC, or Southern Cal) is a Private university, private research university in Los Angeles, California, United States. Founded in 1880 by Robert M. Widney, it is the oldest private research university in ...
, as well as seven post-doctoral fellows. Cohen is active in international scientific relations, especially in Cuba, and his commentaries have been solicited and published in
The Guardian ''The Guardian'' is a British daily newspaper. It was founded in Manchester in 1821 as ''The Manchester Guardian'' and changed its name in 1959, followed by a move to London. Along with its sister paper, ''The Guardian Weekly'', ''The Guardi ...
,
The New Yorker ''The New Yorker'' is an American magazine featuring journalism, commentary, criticism, essays, fiction, satire, cartoons, and poetry. It was founded on February 21, 1925, by Harold Ross and his wife Jane Grant, a reporter for ''The New York T ...
,
BuzzFeed BuzzFeed, Inc. is an American Internet mass media, media, news and entertainment company with a focus on digital media. Based in New York City, BuzzFeed was founded in 2006 by Jonah Peretti and John Seward Johnson III, John S. Johnson III to ...
, and other news media.


Academic research

Cohen's achievements in
MRI Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to generate pictures of the anatomy and the physiological processes inside the body. MRI scanners use strong magnetic fields, magnetic field gradients, and rad ...
include the earliest clinical uses of
echo-planar imaging Magnetic resonance imaging (MRI) is a medical imaging technique mostly used in radiology and nuclear medicine in order to investigate the anatomy and physiology of the body, and to detect pathologies including tumors, inflammation, neurological ...
, defining the safe boundaries of operation of high-end MRI units. While at Advanced NMR Systems he partnered with Jack Belliveau and others at
Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...
to create the first functional images of the human brain by MRI using the ultra-fast instrument he and his collaborators built. The latter work appeared in ''
Science Science is a systematic discipline that builds and organises knowledge in the form of testable hypotheses and predictions about the universe. Modern science is typically divided into twoor threemajor branches: the natural sciences, which stu ...
'' as cover art, using a now canonical image that Cohen designed. After moving to
Harvard Harvard University is a private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher lear ...
he went on to play a crucial role in the second major advancement in functional MRI - allowing observation of brain function without injected contrast agents - that resulted in
Kenneth Kwong Kenneth Kin Man Kwong is a Hong Kong-born American nuclear physicist. He is a pioneer in human brain imaging. He received his bachelor's degree in Political Science in 1972 from the University of California, Berkeley. He went on to receive his P ...
's seminal paper (in the same year that Ogawa and colleagues submitted their results subsequently published a year later in PNAS)),using the ultra-fast instrument he and his collaborators built. As a co-inventor of
functional MRI Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area o ...
, Cohen created a
iconic cover for Science magazine
that became a canonical standard for presentation of such data, and that has been reproduced widely. With his original training in neurophysiology, Cohen was interested developing a practical means of recording brain electrical signals
EEG Electroencephalography (EEG) is a method to record an electrogram of the spontaneous electrical activity of the brain. The bio signals detected by EEG have been shown to represent the postsynaptic potentials of pyramidal neurons in the neoc ...
simultaneously with
fMRI Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area o ...
. The method that he created was licensed to Electrical Geodesics, Inc. and sold as the GES300MR. With his student, Robin Goldman, he demonstrated strong functional associations between MRI and EEG signals. Cohen has developed multiple experimental methods to enable studies of the brain’s physical structure/mental structure interface. These methods include ultrafast imaging techniques, fMRI, simultaneous EEG and MRI, machine-learning methods for decoding brain images, and focused ultrasound brain stimulation. He has applied these tools to the investigation of mental imagery, time perception, racial/religious bias, the neurology of belief, and lie detection. He also has used MRI methods to better detect and understand major psychiatric and neurological disorders including
schizophrenia Schizophrenia () is a mental disorder characterized variously by hallucinations (typically, Auditory hallucination#Schizophrenia, hearing voices), delusions, thought disorder, disorganized thinking and behavior, and Reduced affect display, f ...
,
obsessive compulsive disorder Obsession may refer to: Psychology * Celebrity worship syndrome, obsessive addictive disorder to a celebrity's personal and professional life * Obsession (psychology), a persistent attachment to an object or idea * Fixation (psychology), persi ...
,
epilepsy Epilepsy is a group of Non-communicable disease, non-communicable Neurological disorder, neurological disorders characterized by a tendency for recurrent, unprovoked Seizure, seizures. A seizure is a sudden burst of abnormal electrical activit ...
, depression,
dementia Dementia is a syndrome associated with many neurodegenerative diseases, characterized by a general decline in cognitive abilities that affects a person's ability to perform activities of daily living, everyday activities. This typically invo ...
,
bipolar disorder Bipolar disorder (BD), previously known as manic depression, is a mental disorder characterized by periods of Depression (mood), depression and periods of abnormally elevated Mood (psychology), mood that each last from days to weeks, and in ...
,
addiction Addiction is a neuropsychological disorder characterized by a persistent and intense urge to use a drug or engage in a behavior that produces natural reward, despite substantial harm and other negative consequences. Repetitive drug use can ...
,
ADHD Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterised by symptoms of inattention, hyperactivity, impulsivity, and emotional dysregulation that are excessive and pervasive, impairing in multiple ...
,
autism Autism, also known as autism spectrum disorder (ASD), is a neurodevelopmental disorder characterized by differences or difficulties in social communication and interaction, a preference for predictability and routine, sensory processing d ...
, and others.


References

{{DEFAULTSORT:Cohen, Mark S. Living people American neuroscientists 1956 births People from Calabasas, California Scientists from Pasadena, California Scientists from Saint Paul, Minnesota