Marjorie Constance Caserio
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Marjorie Constance Caserio (née Beckett; February 26, 1929 – April 19, 2021) was an English chemist. In 1975, she was awarded the
Garvan Medal Garvan may refer to: People * Francis Patrick Garvan (1875–1937), American lawyer, president of the Chemical Foundation * Frank Garvan (born 1955), Australian mathematician * Genevieve Garvan Brady (1880–1938), American philanthropist and Papa ...
by the
American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all ...
.


Early life and education

Caserio was born Marjorie Constance Beckett in Cricklewood, London, England. She attended the
North London Collegiate School North London Collegiate School (NLCS) is a private day school for girls in England. Founded in Camden Town, it is now located in Edgware, in the London Borough of Harrow. Associate schools are located in South Korea, Jeju Island, Dubai, Vietnam ...
and began studying
podiatry Podiatry ( ), also know as podiatric medicine and surgery ( ), is a branch of medicine devoted to the study, diagnosis, and treatment of disorders of the foot, ankle and lower limb. The healthcare professional is known as a podiatrist. The US ...
at Chelsea College, but soon developed a preference for chemistry and graduated with honors in the subject in 1950. She was awarded a Sir John Dill Fellowship by the
English-Speaking Union The English-Speaking Union (ESU) is an international educational membership organisation headquartered in London, England. Founded by the journalist Sir Evelyn Wrench in 1918, it aims to bring together and empower people of different languages ...
which allowed her to study at
Bryn Mawr College Bryn Mawr College ( ; Welsh language, Welsh: ) is a Private college, private Women's colleges in the United States, women's Liberal arts colleges in the United States, liberal arts college in Bryn Mawr, Pennsylvania, United States. Founded as a ...
in the United States, she earned an M.A. in chemistry in 1951. Her thesis was entitled "The alkaline hydrolysis of ethyl ''p''-alkybenzoates." For a year she worked at the
Fulmer Research Institute Fulmer Research Institute was founded in 1945 as a UK contract research and development organization specializing in materials technology and related areas of physics and chemistry. It was modelled on American contract research companies such a ...
in rural
Stoke Poges Stoke Poges () is a village and civil parish in south-east Buckinghamshire, England. It is centred north-north-east of Slough, its post town, and is southeast of Farnham Common. In 2021, it had a population of 5,067. Geography Hamlets withi ...
,
England England is a Countries of the United Kingdom, country that is part of the United Kingdom. It is located on the island of Great Britain, of which it covers about 62%, and List of islands of England, more than 100 smaller adjacent islands. It ...
, researching the effects of
fluoride Fluoride (). According to this source, is a possible pronunciation in British English. is an Inorganic chemistry, inorganic, Monatomic ion, monatomic Ion#Anions and cations, anion of fluorine, with the chemical formula (also written ), whose ...
s on
titanium Titanium is a chemical element; it has symbol Ti and atomic number 22. Found in nature only as an oxide, it can be reduced to produce a lustrous transition metal with a silver color, low density, and high strength, resistant to corrosion in ...
, but disliked the work and decided to seek a Ph.D. in chemistry. She interviewed with
Nobel laureate The Nobel Prizes (, ) are awarded annually by the Royal Swedish Academy of Sciences, the Swedish Academy, the Karolinska Institutet, and the Norwegian Nobel Committee to individuals and organizations who make outstanding contributions in th ...
Derek Barton Sir Derek Harold Richard Barton (8 September 1918 – 16 March 1998) was an English organic chemist and Nobel Prize laureate for 1969. Education and early life Barton was born in Gravesend, Kent, to William Thomas and Maude Henrietta Barton ...
and was accepted to
Birkbeck College Birkbeck, University of London (formally Birkbeck College, University of London), is a public research university located in London, England, and a member institution of the University of London. Established in 1823 as the London Mechanics' ...
in
London London is the Capital city, capital and List of urban areas in the United Kingdom, largest city of both England and the United Kingdom, with a population of in . London metropolitan area, Its wider metropolitan area is the largest in Wester ...
, but was not offered financial aid. Instead, Caserio returned to Bryn Mawr in the U.S., earning her Ph.D. in 1956 with a dissertation entitled "The kinetics of bromination of naphthalene."


Career

Caserio was hired by John D. Roberts for a postdoctoral position at the
California Institute of Technology The California Institute of Technology (branded as Caltech) is a private research university in Pasadena, California, United States. The university is responsible for many modern scientific advancements and is among a small group of institutes ...
. She spent eight years at Caltech, working on 3- and 4-membered ring compounds, the reactions of
alcohol Alcohol may refer to: Common uses * Alcohol (chemistry), a class of compounds * Ethanol, one of several alcohols, commonly known as alcohol in everyday life ** Alcohol (drug), intoxicant found in alcoholic beverages ** Alcoholic beverage, an alco ...
s with
diazomethane Diazomethane is an organic chemical compound with the formula CH2N2, discovered by German chemist Hans von Pechmann in 1894. It is the simplest diazo compound. In the pure form at room temperature, it is an extremely sensitive explosive yellow ga ...
, the
hydrolysis Hydrolysis (; ) is any chemical reaction in which a molecule of water breaks one or more chemical bonds. The term is used broadly for substitution reaction, substitution, elimination reaction, elimination, and solvation reactions in which water ...
of diaryliodonium salts, the deamination of
nitrous acid Nitrous acid (molecular formula ) is a weak and monoprotic acid known only in solution, in the gas phase, and in the form of nitrite () salts. It was discovered by Carl Wilhelm Scheele, who called it " phlogisticated acid of niter". Nitrous ac ...
, and benzyne
reaction intermediate In chemistry, a reaction intermediate, or intermediate, is a molecular entity arising within the sequence of a stepwise chemical reaction. It is formed as the reaction product of an elementary step, from the reactants and/or preceding interme ...
s in
nucleophilic aromatic substitution A nucleophilic aromatic substitution (SNAr) is a substitution reaction in organic chemistry in which the nucleophile displaces a good leaving group, such as a halide, on an aromatic ring. Aromatic rings are usually nucleophilic, but some aromatic c ...
reactions. She collaborated with Roberts in writing an
organic chemistry Organic chemistry is a subdiscipline within chemistry involving the science, scientific study of the structure, properties, and reactions of organic compounds and organic matter, organic materials, i.e., matter in its various forms that contain ...
textbook, ''Basic Principles of Organic Chemistry'', first published in 1964. Notable for its comprehensiveness and then-unusual emphasis on
spectroscopy Spectroscopy is the field of study that measures and interprets electromagnetic spectra. In narrower contexts, spectroscopy is the precise study of color as generalized from visible light to all bands of the electromagnetic spectrum. Spectro ...
, it proved enormously influential in how the subject was taught. Also working with Roberts was chemist Fred Caserio.


University of California, Irvine

In 1964, Caserio was hired as the second faculty member in chemistry at the brand new
University of California, Irvine The University of California, Irvine (UCI or UC Irvine) is a Public university, public Land-grant university, land-grant research university in Irvine, California, United States. One of the ten campuses of the University of California system, U ...
. At UC Irvine she worked on
addition reaction In organic chemistry, an addition reaction is an organic reaction in which two or more molecule A molecule is a group of two or more atoms that are held together by Force, attractive forces known as chemical bonds; depending on context, ...
s in
allene In organic chemistry, allenes are organic compounds in which one carbon atom has double bonds with each of its two adjacent carbon atoms (, where R is hydrogen, H or some organyl group). Allenes are classified as diene#Classes, cumulated dienes ...
s and bonding and reactions of
sulfur Sulfur ( American spelling and the preferred IUPAC name) or sulphur ( Commonwealth spelling) is a chemical element; it has symbol S and atomic number 16. It is abundant, multivalent and nonmetallic. Under normal conditions, sulfur atoms ...
compounds. She was one of the first scientists to employ
nuclear magnetic resonance Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are disturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with a ...
spectroscopy to study the kinetics and mechanisms of these organic reactions, and
ion cyclotron resonance Ion cyclotron resonance is a phenomenon related to the movement of ions in a magnetic field. It is used for accelerating ions in a cyclotron, and for measuring the masses of an ionized analyte in mass spectrometry, particularly with Fourier transfor ...
to study gas-phase reactions. Caserio became a full professor at UC Irvine in 1972, and chair of the chemistry department in 1987.


University of California, San Diego

In 1990, she became vice chancellor for academic affairs at the
University of California, San Diego The University of California, San Diego (UC San Diego in communications material, formerly and colloquially UCSD) is a public university, public Land-grant university, land-grant research university in San Diego, California, United States. Es ...
. She later served as interim chancellor, and retired in 1996.


Personal life and death

In 1957, she married Fred Caserio; she became a US citizen the same year. They had two sons. She died in 2021, aged 92, on a trip to
Mexico Mexico, officially the United Mexican States, is a country in North America. It is the northernmost country in Latin America, and borders the United States to the north, and Guatemala and Belize to the southeast; while having maritime boundar ...
.Obituary
cucea.org. Accessed February 21, 2024.


References


Books

* *


External links


A video interview of Caserio


{{DEFAULTSORT:Caserio, Marjorie 1929 births 2021 deaths Bryn Mawr College alumni California Institute of Technology faculty University of California, Irvine faculty University of California, San Diego administrators Recipients of the Garvan–Olin Medal American women chemists 21st-century American chemists American women academics English emigrants to the United States People from Cricklewood 21st-century American women scientists Naturalized citizens of the United States Graduate Women in Science members