Manuel I may refer to:
*
Manuel I Komnenos
Manuel I Komnenos (; 28 November 1118 – 24 September 1180), Latinized as Comnenus, also called Porphyrogenitus (; " born in the purple"), was a Byzantine emperor of the 12th century who reigned over a crucial turning point in the history o ...
, Byzantine emperor (1143–1180)
*
Manuel I of Trebizond, Emperor of Trebizond (1228–1263)
*
Manuel I of Portugal, King of Portugal (1496–1521)
*
Manuel I, Patriarch of Lisbon (1800–1869)
{{hndis, Manuel 01