Makhoul is a surname. Notable people with the surname include:
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Ameer Makhoul, Israeli Palestinian Christian convicted in 2011 of espionage
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Issam Makhoul (born 1952), Israeli Arab politician
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John Makhoul
John Makhoul is a Lebanese-American computer scientist who works in the field of speech and language processing. Dr. Makhoul's work on linear predictive coding was used in the establishment of the Network Voice Protocol, which enabled the transm ...
, Lebanese-American computer scientist
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Leena Makhoul (born 1993), Palestinian singer-songwriter
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