Main Building is a common name for a building on some university and college campuses serving as home to administrative offices, such as president or provost and may refer to:

Austria

* Main building (University of Vienna)

Canada

* Main Building (Statistics Canada)

Hong Kong

* HSBC Main Building, Hong Kong, the headquarters of The Hongkong and Shanghai Banking Corporation

Iceland

* University of Iceland Main Building

Philippines

* Main Building (University of Santo Tomas)

Russia

* Ministry of Foreign Affairs of Russia main building, Moscow * Main building of Moscow State University

Sweden

* Lund University Main Building

United Kingdom

* UCL Main Building, at University College London * Ministry of Defence Main Building (United Kingdom), Whitehall, London

United States

* Main Building, Arkansas Baptist College, Little Rock, Arkansas * Main Building (Torrance High School), at Torrance High School in Torrance, California * Main Building (University of Notre Dame), South Bend, Indiana * Main Building (University of Kentucky), at the University of Kentucky in Lexington, Kentucky * Xavier University Main Building, Convent and Library, New Orleans, Louisiana * Main Building, Concordia College, a National Register of Historic Places listing in Clay County, Minnesota * Camden Free Public Library Main Building, Camden, New Jersey * New Mexico Military Institute Summer Camp, Main Building, a National Register of Historic Places listing in Lincoln County, New Mexico * Low Memorial Library, Columbia University, New York, New York * Hudson River State Hospital, Main Building, Poughkeepsie, New York * Main Building (Vassar College), Poughkeepsie, New York * Main Building, Louisburg College, Louisburg, North Carolina, built by Albert Gamaliel Jones * North Carolina School for the Deaf: Main Building, Morganton, North Carolina, built by A.G. Bauer * Peace College Main Building, Raleigh, North Carolina * Main Building, Mitchell College, Statesville, North Carolina * Main Building School, Wilmington, Ohio * Main Building, U.S. Bureau of Mines, Pittsburgh, Pennsylvania * Lander College Old Main Building, Greenwood, South Carolina * All Saints School Main Building, Sioux Falls, South Dakota * Main Building (St. Edward's University), Austin, Texas * Main Building (University of Texas at Austin) * Main Building, Blinn College, a National Register of Historic Places listing in Washington County, Texas * Main Building (University of Houston–Downtown) or Merchants and Manufacturers Building, Houston, Texas * Old Main (Texas State University) or Main Building, Southwest Texas Normal School, San Marcos, Texas * Main Building of Dixie College, a National Register of Historic Places listing in Washington County, Utah * Southern Seminary Main Building, Buena Vista, Virginia * Main Building (Montgomery, West Virginia) * Mary Baldwin College, Main Building, Staunton, Virginia