Mafoprazine is an
antipsychotic
Antipsychotics, previously known as neuroleptics and major tranquilizers, are a class of Psychiatric medication, psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), p ...
of the phenylpiperazine class which is used in
veterinary medicine
Veterinary medicine is the branch of medicine that deals with the prevention, management, medical diagnosis, diagnosis, and treatment of disease, disorder, and injury in non-human animals. The scope of veterinary medicine is wide, covering all a ...
. Intramuscular injections of mafoprazine mesylate are used for the sedation of pigs either on its own, or in combination with sodium pentobarbital or thiopental.
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Pharmacology
It demonstrates activity as a D
2 dopamine receptor antagonist, an α
1 adrenergic receptor antagonist, and an α
2 adrenergic receptor agonist.
The affinity of mafoprazine for D
2 dopamine receptors is 6 and 16 times lower than that of
chlorpromazine
Chlorpromazine (CPZ), marketed under the brand names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar d ...
and haloperidol, respectively, but 2 times higher than that of azaperone.
[
The ''K''i for various receptors was determined using rat neuronal receptor binding assays.
]
History
Mafoprazine was first synthesized in 1988.[ It is sold as Mafropan® by DS Pharma Animal Health Co. Ltd., Osaka, Japan.
]
References
{{Reflist
Veterinary medicine
Piperazines
2-Fluorophenyl compounds
Acetamides
O-methylated phenols
Propoxy compounds