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MRC-5 ( Medical Research Council cell strain 5) is a diploid cell culture line composed of
Cellosaurus entry for MRC-5
Human cell lines {{vaccine-stub
MRC-5 ( Medical Research Council cell strain 5) is a diploid cell culture line composed of fibroblast
A fibroblast is a type of biological cell that synthesizes the extracellular matrix and collagen, produces the structural framework ( stroma) for animal tissues, and plays a critical role in wound healing. Fibroblasts are the most common cells of ...
s, originally developed from the lung tissue of a 14-week-old aborted
Aborted is a Belgian death metal band formed in 1995 in Waregem. The group currently consists of vocalist, founder and only constant member Sven de Caluwé, guitarist Ian Jekelis, bassist Stefano Franceschini and drummer Ken Bedene. Although t ...
Caucasian male fetus
A fetus or foetus (; plural fetuses, feti, foetuses, or foeti) is the unborn offspring that develops from an animal embryo. Following embryonic development the fetal stage of development takes place. In human prenatal development, fetal develo ...
. The cell line was isolated by J.P. Jacobs and colleagues in September 1966 from the seventh population doubling of the original strain, and MRC-5 cells themselves are known to reach senescence
Senescence () or biological aging is the gradual deterioration of functional characteristics in living organisms. The word ''senescence'' can refer to either cellular senescence or to senescence of the whole organism. Organismal senescence inv ...
in around 45 population doublings.
Applications
MRC-5 cells are currently used to produce several vaccines including forhepatitis A
Hepatitis A is an infectious disease of the liver caused by ''Hepatovirus A'' (HAV); it is a type of viral hepatitis. Many cases have few or no symptoms, especially in the young. The time between infection and symptoms, in those who develop the ...
, varicella and polio
Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 70% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe sym ...
.
Culture and society
During theCOVID-19 pandemic
The COVID-19 pandemic, also known as the coronavirus pandemic, is an ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The novel virus was first identified ...
, anti-vaccination and anti-abortion
Anti-abortion movements, also self-styled as pro-life or abolitionist movements, are involved in the abortion debate advocating against the practice of abortion and its legality. Many anti-abortion movements began as countermovements in respo ...
activists believed that MRC-5 was an ingredient of the Oxford–AstraZeneca COVID-19 vaccine
The Oxford–AstraZeneca COVID19 vaccine, sold under the brand names Covishield and Vaxzevria among others, is a viral vector vaccine for prevention of COVID-19. Developed in the United Kingdom by Oxford University and British-Swedish com ...
, citing a study from the University of Bristol. David Matthews, a co-author for this study, clarified that MRC-5 was solely used for testing purposes to determine "how the Oxford vaccine behaves when it is inside a genetically normal human cell." The manufacturing of the vaccine used the HEK 293
Human embryonic kidney 293 cells, also often referred to as HEK 293, HEK-293, 293 cells, or less precisely as HEK cells, are a specific immortalised cell line derived from a spontaneously miscarried or aborted fetus or human embryonic kidney cells ...
fetal cell line, the kidney cells of an aborted or spontaneously miscarried female fetus, though the cells are filtered out of the final product.
See also
* Use of fetal tissue in vaccine development * WI-38References
External links
Cellosaurus entry for MRC-5
Human cell lines {{vaccine-stub