ML337 is an experimental drug that acts as a negative

allosteric modulator In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimuli. Some of them, like benzodiazepines or alcohol, function as psychoactive drugs. The site that a ...

selective for the

glutamate Glutamic acid (symbol Glu or E; known as glutamate in its anionic form) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins. It is a Essential amino acid, non-essential nutrient for humans, meaning that ...

receptor mGluR3. It has only moderate potency with an IC₅₀ of 450 nM, but is highly selective over the closely related subtype mGluR2 with no effect even at 30,000 nM, and so has been used to study the effects of mGluR3 in isolation, which had previously been difficult to separate from mGluR2 mediated effects.

References

Experimental drugs Alcohols Alkynes Benzamides Benzene derivatives Fluorobenzenes Methoxy compounds Piperidines {{nervous-system-drug-stub