ML-154 (NCGC-84) is a

drug A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via inhal ...

which acts as a selective, non-

peptide Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. ...

antagonist at the

neuropeptide S Neuropeptide S (NPS) is a neuropeptide found in human and mammalian brain, mainly produced by neurons in the amygdala and between Barrington's nucleus and the locus coeruleus, although NPS-responsive neurons extend projections into many other brai ...

receptor NPSR. In animal studies it decreases self-administration of alcohol in addicted rats, and lowers motivation for alcohol rewards, suggesting a potential application for NPS antagonists in the treatment of alcoholism.

References

Phosphorus compounds Sulfur compounds Phenyl compounds Alkene derivatives Quaternary ammonium compounds Bromides {{nervous-system-drug-stub

See also

References