MKI67 FHA domain-interacting nucleolar phosphoprotein is a
protein that in humans is encoded by the ''MKI67IP''
gene.
MKI67 FHA domain-interacting nucleolar phosphoprotein contains an
RNA recognition motif (RRM) near to the
N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the ami ...
and a FHA
Ki67 binding domain near to the
C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH). When the protein is ...
. There are two
conserved sequence motifs within the FHA Ki67 binding domain: TPVCTP and LERRKS, this
domain
Domain may refer to:
Mathematics
*Domain of a function, the set of input values for which the (total) function is defined
**Domain of definition of a partial function
**Natural domain of a partial function
**Domain of holomorphy of a function
* Do ...
binds to the
forkhead-associated domain of
human Ki67. High-affinity binding requires sequential
phosphorylation
In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, wh ...
by two
kinases,
CDK1 and
GSK3, yielding
pThr238, pThr234 and
pSer230. This interaction is involved in
cell cycle regulation.
References
Further reading
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External links
PDBe-KBprovides an overview of all the structure information available in the PDB for Human MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)
Protein domains
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