Beta-1,3-N-acetylglucosaminyltransferase manic fringe is an

enzyme An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...

that in humans is encoded by the ''MFNG''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

, a member of the fringe gene family which also includes the ''radical fringe'' ( RFNG) and ''lunatic fringe'' (

LFNG Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe, also known as Lunatic Fringe, is a protein encoded in humans by the ''LFNG'' gene. This gene encodes a member of the glycosyltransferase superfamily. The encoded protein is a single-pass t ...

)."Sonic Hedgehog, DICER, and the Problem With Naming Genes"
Sep 26, 2014, Michael White. psmag.com They all encode evolutionarily conserved proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.

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