The MENTAL or MLN64 NH
2-terminal domain is a membrane-spanning domain that is conserved in two
late endosomal proteins in vertebrates,
MLN64 StAR related lipid transfer domain containing 3 (STARD3) is a protein that in humans is encoded by the STARD3 gene. STARD3 also known as metastatic lymph node 64 protein (MLN64) is a late endosomal integral membrane protein involved in cholesterol ...
and
MENTHO.
The domain is 170
amino acids long.
Current data indicates that this domain allows for
dimerization between MLN64 and MENTHO molecules and with themselves.
The domain may also direct
cholesterol
Cholesterol is any of a class of certain organic molecules called lipids. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell membr ...
transport.
References
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Protein domains