Mediator of RNA polymerase II transcription subunit 4 also known as mediator complex subunit 4 (MED4), a component of

Mediator Mediation is a structured, voluntary process for resolving disputes, facilitated by a neutral third party known as the mediator. It is a structured, interactive process where an independent third party, the mediator, assists disputing parties ...

or vitamin D3 receptor-interacting protein complex 36 kDa component (DRIP36) is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

that in humans is encoded by the ''MED4''

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

Function

The

encoded by this gene is a component of the

vitamin D receptor The vitamin D receptor (VDR also known as the calcitriol receptor) is a member of the nuclear receptor family of transcription factors. Calcitriol (the active form of vitamin D, 1,25-(OH)2vitamin D3) binds to VDR, which then forms a heterodi ...

-interacting protein (

DRIP Drip, The Drip, or DRIP may refer to: * Drop (liquid) Biology and medicine * Intravenous therapy * Vitamin D receptor interacting protein (DRIP) * Mesomycetozoea, a class of eukaryotes (also known as ''DRIP clade'') * Murphy drip, in proctocl ...

) complex which functions as a

nuclear receptor In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules. These intracellular receptors work with other proteins to regulate the ex ...

coactivator A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes. The activator contains a DNA binding domain that binds either to a DNA ...

. The DRIP complex is capable of activating nuclear receptors in a ligand-dependent manner.

Interactions

MED4 has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...

with

MED25 Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the ''MED25'' gene. Intellectual developmental disorder A homozygous variant in the MED25 gene, leading to an arginine to trypsin substitution, wa ...

Function

Interactions

References

Further reading