MBL deficiency is a pathology of the

innate immune system The innate, or nonspecific, immune system is one of the two main immunity strategies (the other being the adaptive immune system) in vertebrates. The innate immune system is an older evolutionary defense strategy, relatively speaking, and is th ...

involving

Mannan-binding lectin pathway The lectin pathway or lectin complement pathway is a type of cascade reaction in the complement system, similar in structure to the classical complement pathway, in that, after activation, it proceeds through the action of C4 and C2 to produce acti ...

components such as

MBL2 Mannose-binding lectin (MBL), also called mannan-binding lectin or mannan-binding protein (MBP), is a lectin that is instrumental in innate immunity as an opsonin and via the lectin pathway. Structure MBL has an oligomeric structure (400-700 kDa) ...

. It is thought that 5–10% of the population have an MBL deficiency of some degree. There are varying degrees of MBL deficiency; some people will not even know they have the deficiency, while others may have such low levels that they experience infections with great frequency. Babies and young children are most at risk.

References

External links

Complement deficiency {{circulatory-disease-stub