Methyl-CpG-binding domain protein 3 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''MBD3''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins
MECP2,
MBD1,
MBD2
Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the ''MBD2'' gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in D ...
, MBD3, and
MBD4 comprise a family of nuclear proteins related by the presence in each of a
methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA but instead binds to
hydroxymethylated DNA.
The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the
NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.
MBD3 also contains the
coiledâcoil domain common to all three MBD3 isoforms.
Interactions
MBD3 has been shown to
interact with:
*
AURKA,
*
GATAD2B,
*
HDAC1,
[ and
* ]MBD2
Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the ''MBD2'' gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in D ...
.
References
Further reading
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{{refend
Human proteins