The MAS1 oncogene (MAS receptor) is a
G protein-coupled receptor
G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related p ...
which binds the
angiotensin II
Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure. It is part of the renin–angiotensin system, which regulates blood pressure. Angiotensin also stimulates the release of aldosterone from the adr ...
metabolite
angiotensin (1-7).
The MAS1 receptor, when activated by binding angiotensin-(1-7), opposes many of the effects of the
angiotensin II receptor. Hence, MAS1 receptor
agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
s have similar therapeutic effects to
angiotensin II receptor antagonists
Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT1) antagonists, also known as angiotensin receptor blockers, angiotensin II receptor antagonists, or AT1 receptor antagonists, are a group of pharmaceuticals tha ...
, including lowering of blood pressure.
References
External links
IUPHAR GPCR Database - MAS1IUPHAR GPCR Database - MAS1L*
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