E3 ubiquitin-protein ligase MARCH2 is an

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different molecule ...

that in humans is encoded by the ''MARCH2''

gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

. It is a member of the MARCH family of E3 ligases, and plays an important role in the

turnover Turnover or turn over may refer to: Arts, entertainment, and media *''Turn Over'', a 1988 live album by Japanese band Show-Ya * Turnover (band), an American rock band *"Turnover", a song on Fugazi's 1990 album '' Repeater'' *''Turnover'', a Japane ...

membrane proteins Membrane proteins are common proteins that are part of, or interact with, biological membranes. Membrane proteins fall into several broad categories depending on their location. Integral membrane proteins are a permanent part of a cell membrane ...

. MARCH2 has been shown to negatively regulate NF-κB essential modulator function upon viral and bacterial

infections An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable dise ...

Gene name error in Excel

Like the other MARCH and

septin Septins are a group of GTP-binding proteins expressed in all eukaryotic cells except plants. Different septins form protein complexes with each other. These complexes can further assemble into filaments, rings and gauzes. Assembled as such, sep ...

genes, care must be exercised when analyzing genetic data containing the MARCH2 gene in

Microsoft Excel Microsoft Excel is a spreadsheet developed by Microsoft for Windows, macOS, Android and iOS. It features calculation or computation capabilities, graphing tools, pivot tables, and a macro programming language called Visual Basic for ...

. This is due to Excel's autocorrect feature treating the MARCH gene as a date and converting it to a standard date format. The original text cannot be recovered as a result of the conversion. A 2016 study found up to 19.6% of all papers in selected journals to be affected by the gene name error. The issue can be prevented by using an alias name such as MARCHF2, prepending with an apostrophe ('), or preformatting the cell as text.

Gene name error in Excel

References

Further reading