MAM domain is an evolutionary conserved

protein domain In molecular biology, a protein domain is a region of a protein's Peptide, polypeptide chain that is self-stabilizing and that Protein folding, folds independently from the rest. Each domain forms a compact folded Protein tertiary structure, thre ...

. It is an extracellular domain found in many receptors. A 170 amino acid domain, the so-called MAM (meprin, A-5 protein, and receptor protein-tyrosine phosphatase mu) domain, has been recognised in the extracellular region of functionally diverse proteins. These proteins have a modular, receptor-like architecture comprising a

signal peptide A signal peptide (sometimes referred to as signal sequence, targeting signal, localization signal, localization sequence, transit peptide, leader sequence or leader peptide) is a short peptide (usually 16–30 amino acids long) present at the ...

, an N-terminal extracellular domain, a single transmembrane domain and an intracellular domain. Such proteins include meprin (a cell surface glycoprotein); A5 antigen (a developmentally-regulated cell surface protein; ''Xenopus''

nrp1 Neuropilin-1 is a protein that in humans is encoded by the ''NRP1'' gene. In humans, the neuropilin 1 gene is located at 10p11.22. This is one of two human neuropilins. Function NRP1 is a membrane-bound coreceptor to a tyrosine kinase rec ...

; ); and receptor-like tyrosine protein phosphatase. The MAM domain is thought to have an adhesive function. It contains 4 conserved

cysteine Cysteine (; symbol Cys or C) is a semiessential proteinogenic amino acid with the chemical formula, formula . The thiol side chain in cysteine enables the formation of Disulfide, disulfide bonds, and often participates in enzymatic reactions as ...

residues, which probably form

disulphide bridge In chemistry, a disulfide (or disulphide in British English) is a compound containing a functional group or the anion. The linkage is also called an SS-bond or sometimes a disulfide bridge and usually derived from two thiol groups. In inorg ...

Human proteins containing this domain

ALK; EGFL6; MAMDC2; MAMDC4; MDGA1; MDGA2;

MEP1A Meprin A subunit alpha also known as endopeptidase-2 or PABA peptide hydrolase is the alpha subunit of the meprin A enzyme that in humans is encoded by the ''MEP1A'' gene. The MEP1A locus is on chromosome 6p in humans and on chromosome 17 in mice. ...

;

MEP1B Meprin A subunit beta is a protein that in humans is encoded by the ''MEP1B'' gene. Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney The mammalian kidneys are a pair of excretory organs of the urinary ...

; NPNT;

NRP1 Neuropilin-1 is a protein that in humans is encoded by the ''NRP1'' gene. In humans, the neuropilin 1 gene is located at 10p11.22. This is one of two human neuropilins. Function NRP1 is a membrane-bound coreceptor to a tyrosine kinase rec ...

;

NRP2 Neuropilin 2 (NRP2) is a protein that in humans is encoded by the ''NRP2'' gene. This gene encodes a member of the neuropilin Neuropilin is a protein receptor active in neurons. There are two forms of Neuropilins, NRP-1 and NRP-2. Neurop ...

; PRSS7;

PTPRK Receptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the ''PTPRK'' gene. PTPRK is also known as PTPkappa and PTPκ. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase ...

;

PTPRM Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the ''PTPRM'' gene. Function The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Protein tyrosine phosphatases ...

;

PTPRO Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the ''PTPRO'' gene. This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic sig ...

;

PTPRT Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the ''PTPRT'' gene. PTPRT is also known as PTPrho, PTPρ and human accelerated region 9. The human accelerated regions are 49 regions of the human genome tha ...

;

PTPRU Receptor-type tyrosine-protein phosphatase PCP-2 (also known as PTP-pi, PTP lambda, hPTP-J, PTPRO and PTP psi), is an enzyme that in humans is encoded by the ''PTPRU'' gene. Function The protein encoded by this gene is a member of the protein ...

;

ZAN Zan or ZAN, may refer to: Geography * Zhan, Kurdistan, Iran, also known as Zān * Zhan, Lorestan, Iran, also known as Žān * Zan, Tehran, a village in Tehran Province, Iran * Zan, a town in Lebanon, also known as Zane Ethnicity and language ...

References

Protein domains Single-pass transmembrane proteins {{membrane-protein-stub