M320 is an extremely potent and long acting
opioid
Opioids are a class of Drug, drugs that derive from, or mimic, natural substances found in the Papaver somniferum, opium poppy plant. Opioids work on opioid receptors in the brain and other organs to produce a variety of morphine-like effects, ...
. It produces long lasting
narcosis in different animals, including mice, rats, cats, guinea pigs, dogs and monkeys.
M320 is a
μ and
κ-opioid receptor
The κ-opioid receptor or kappa opioid receptor, abbreviated KOR or KOP for its ligand ketazocine, is a G protein-coupled receptor that in humans is encoded by the ''OPRK1'' gene. The KOR is coupled to the G protein Gi/G0 and is one of four re ...
agonist
An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...
.
See also
*
Bentley compounds
Bentley Motors Limited is a British designer, manufacturer and marketer of luxury cars and SUVs. Headquartered in Crewe, England, the company was founded by W. O. Bentley (1888–1971) in 1919 in Cricklewood, North London, and became wide ...
*
BU72
BU72 is an extremely potent opioid used in pharmacological research.
Pharmacology
BU72 is an agonist for the μ-opioid receptor with exceptionally high binding affinity and Potency (pharmacology), potency, comparable to carfentanil. It also ...
*
Carfentanil
Carfentanil or carfentanyl, formerly sold under the brand name Wildnil, is an extremely potent opioid analgesic used in veterinary medicine to anesthetize large animals such as elephants and rhinoceroses. It is a structural analogue of the ...
*
Etonitazene
Etonitazene, also known as EA-4941 or CS-4640, is a List of benzimidazole opioids, benzimidazole opioid, first reported in 1957, that has been shown to have approximately 1,000 to 1,500 times the potency (pharmacology), potency of morphine in anim ...
*
Etorphine
Etorphine (M99) is a semi-synthetic opioid possessing an analgesic potency approximately 1,000–3,000 times that of morphine. It was first prepared in 1960 from oripavine, which does not generally occur in opium poppy extract but rather the re ...
(M99)
*
Fentanyl
Fentanyl is a highly potent synthetic piperidine opioid primarily used as an analgesic (pain medication). It is 30 to 50 times more Potency (pharmacology), potent than heroin and 50 to 100 times more potent than morphine. Its primary Medici ...
*
TH-030418
References
Semisynthetic opioids
4,5-Epoxymorphinans
Mu-opioid receptor agonists
Kappa-opioid receptor agonists
Heterocyclic compounds with 6 rings
Cyclopropyl compounds
Diols
Methoxy compounds
{{analgesic-stub