Luk Van Parijs
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Luk Van Parijs is a former associate professor of
biology Biology is the scientific study of life and living organisms. It is a broad natural science that encompasses a wide range of fields and unifying principles that explain the structure, function, growth, History of life, origin, evolution, and ...
at the
Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a Private university, private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of moder ...
(MIT) Center for Cancer Research. After investigating for a year, MIT fired Van Parijs for research misconduct. Van Parijs admitted to fabricating and falsifying research data in a paper, several unpublished manuscripts, and grant applications. In March 2011, Van Parijs pleaded guilty in a U.S. District Court in Boston to one count of making a false statement on a federal grant application. The government asked Judge Denise Casper for a 6-month jail term because of the seriousness of the fraud, which involved a $2-million grant. After several prominent scientists including Van Parijs' former post-doc supervisor pleading for clemency on his behalf, on 13 June, Van Parijs was finally sentenced six months of home detention with electronic monitoring, plus 400 hours of community service and a payment to MIT of $61,117 - restitution for the already-spent grant money that MIT had to return to the National Institutes of Health. Van Parijs' area of research was in the use of short-interference RNA in studying disease mechanisms, especially in autoimmune diseases. He was studying normal
immune cell White blood cells (scientific name leukocytes), also called immune cells or immunocytes, are cell (biology), cells of the immune system that are involved in protecting the body against both infectious disease and foreign entities. White blood c ...
function and defects in these cells during disease development.


Timeline

* About 1970: Born in
Belgium Belgium, officially the Kingdom of Belgium, is a country in Northwestern Europe. Situated in a coastal lowland region known as the Low Countries, it is bordered by the Netherlands to the north, Germany to the east, Luxembourg to the southeas ...
. * Before 1997: Receives
undergraduate Undergraduate education is education conducted after secondary education and before postgraduate education, usually in a college or university. It typically includes all postsecondary programs up to the level of a bachelor's degree. For example, ...
education at
Cambridge University The University of Cambridge is a Public university, public collegiate university, collegiate research university in Cambridge, England. Founded in 1209, the University of Cambridge is the List of oldest universities in continuous operation, wo ...
in
England England is a Countries of the United Kingdom, country that is part of the United Kingdom. It is located on the island of Great Britain, of which it covers about 62%, and List of islands of England, more than 100 smaller adjacent islands. It ...
. * About 1993 - 1997: Works in the laboratory of
Harvard Harvard University is a private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher lear ...
professor Dr. Abul Abbas at
Brigham and Women's Hospital Brigham and Women's Hospital (BWH or The Brigham) is a teaching hospital of Harvard Medical School and the largest hospital in the Longwood Medical Area in Boston, Massachusetts. Along with Massachusetts General Hospital, it is one of the two ...
(BWH). * 1997: Earns
doctorate A doctorate (from Latin ''doctor'', meaning "teacher") or doctoral degree is a postgraduate academic degree awarded by universities and some other educational institutions, derived from the ancient formalism '' licentia docendi'' ("licence to teach ...
in
immunology Immunology is a branch of biology and medicine that covers the study of Immune system, immune systems in all Organism, organisms. Immunology charts, measures, and contextualizes the Physiology, physiological functioning of the immune system in ...
from Harvard. * 1998 - 2000: Postdoctoral student in the laboratory of Dr.
David Baltimore David Baltimore (born March 7, 1938) is an American biologist, university administrator, and 1975 Nobel Prize in Physiology or Medicine, Nobel laureate in Physiology or Medicine. He is a professor of biology at the California Institute of Tech ...
at MIT and
California Institute of Technology The California Institute of Technology (branded as Caltech) is a private research university in Pasadena, California, United States. The university is responsible for many modern scientific advancements and is among a small group of institutes ...
. * 2000: Joins the biology department at MIT. * 2001: Named the Ivan R. Cottrell Career Development Assistant Professor of Immunology at MIT for a three-year term. * July 2004: Promoted to the rank of associate professor at MIT, without tenure. * August 2004: MIT begins a confidential investigation when a group of researchers in van Parijs' laboratory alleges research misconduct. * September 2004: Placed on paid administrative leave and denied access to laboratory by MIT. * 6 October 2005: Caltech begins inquiry (requested by Baltimore, "when ''New Scientist'' pointed out" problems in Caltech papers). (Date & quote: news media #8 and #18, below, respectively.) * 27 October 2005: MIT fires van Parijs. * 28 October 2005: News media coverage begins; Harvard/BWH and Caltech work questioned by ''New Scientist;'' Abbas determining "course of action" in light of ''New Scientist'' enquiries. * 26 January 2006: Data in 2 Caltech patent applications having inventors van Parijs & others questioned in press (News media #16, below). * March 2007: Caltech investigation concludes: van Parijs committed research misconduct; four(4) published papers require correction. * 23 January 2009: Office of Research Integrity's findings of scientific misconduct at Harvard/BWH, Caltech, & MIT as well as van Parijs' Voluntary Exclusion Agreement published in the ''Federal Register:'
Vol. 74, No. 14, Notices, Pp. 4201-2


Literature corrections

(Original paper, correction; Chronological by literature correction - w/in institution of origin.)


Harvard papers

*van Parijs L, Perez VL, Biuckians A, Maki RG, London CA, and Abbas AK (1997) Role of interleukin 12 and costimulators in T cell anergy in vivo. ''Journal of Experimental Medicine'' 186(7): 1119-28 (6 October). ; Open access. **Retraction: "Role of interleukin 12..." by van Parijs, L ''et al.'' ''Journal of Experimental Medicine'' published online 13 April 2009. Retraction by journal editors. Ope
access
*van Parijs L, Peterson DA, and Abbas AK (1998) The Fas/Fas Ligand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign Antigens. ''Immunity'' 8(2): 265-274 (1 February). **van Parijs L, Peterson DA, and Abbas AK (2009) Retraction: The Fas/Fas Ligand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign Antigens. ''Immunity'' 30(4): 611 (17 April).


Caltech papers

*van Parijs L, Refaell Y, Lord JD, Nelson BH, Abbas AK, and Baltimore D (1999) Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death. ''Immunity'' 11(3): 281-288 (1 September). **van Parijs L, Refaell Y, Lord JD, Nelson BH, Abbas AK, and Baltimore D (2009) Retraction: Uncoupling IL-2 Signals that Regulate T Cell Proliferation, Survival, and Fas-Mediated Activation-Induced Cell Death. ''Immunity'' 30(4): 611 (17 April). *van Parijs L, Refaell Y, Abbas AK, and Baltimore D (1999) Autoimmunity as a Consequence of Retrovirus-Mediated Expression of C-FLIP in Lymphocytes. ''Immunity'' 11(6): 763-770 (1 December). **van Parijs L, Refaell Y, Abbas AK, and Baltimore D (2009) Retraction: Autoimmunity as a Consequence of Retrovirus-Mediated Expression of C-FLIP in Lymphocytes. ''Immunity'' 30(4): 612 (17 April).


MIT papers

(Each correction retracts data.) *Nencioni A, Sandy P, Dillon C, Kissler S, Blume-Jensen P, and van Parijs L (2004) RNA interference for the identification of disease-associated genes. ''Current Opinion in Molecular Therapeutics'' 6(2): 136-40 (April). ** (2005) Erratum: [Nencioni A, Sandy P, Dillon C, Kissler S, Blume-Jensen P, and van Parijs L (2004) RNA interference for the identification of disease-associated genes. ''Current Opinion in Molecular Therapeutics'' 6(2): 136–40, ''Current Opinion in Molecular Therapeutics'' 7(3): 282 (June). Pdf availabl
here
*Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Zhang M, McManus MT, Gertler FB, Scott ML, and van Parijs L (2003) A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. ''Nature Genetics'' 33(3): 401-6 (March). ; Figures & tables open access. Authors list subsequently changed twice by "corrigenda": June 2003 (34(2): 231) (Ope

& June 2007 (following ref.). **Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Zhang M, McManus MT, Gertler FB, Scott ML, and van Parijs L (2007) Corrigendum: A lentivirus-based system... ''Nature Genetics'' 39(6): 803 (June). Ope

Data in original paper ''actually removed'' fro

*Kelly E, Won A, Refaeli Y, and van Parijs L (2002) IL-2 and related cytokines can promote T cell survival by activating AKT. ''Journal of Immunology'' 168(2): 597-603 (15 January). ; Open access. **Kelly E, Won A, Refaeli Y, and van Parijs L (2007) Erratum: IL-2 and related cytokines... ''Journal of Immunology'' 179(12): 8569 (15 December). "Retraction" of Figure 5''B''. Ope
access
*Layer K, Lin G, Nencioni A, Hu W, Schmucker A, Antov AN, Li X, Takamatsu S, Chevassut T, Dower NA, Stang SL, Beier D, Buhlmann J, Bronson RT, Elkon KB, Stone JC, Van Parijs L, and Lim B (2003) Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. ''Immunity'' 19(2): 243-55 (August). ; Open access. **Fig. 6A falsified according to ORI findings of misconduct published 23 Jan 2009.


News media

(Chronological) # Robert L. Hotz, "Caltech President Who Raised School's Profile to Step Down" (''Los Angeles Times,'' 4 Oct. 2005, P. A1

# MIT News Office, "MIT professor dismissed for research misconduct" (press release) 27 Oct. 2005; published in News Office's ''TechTalk'' 2 Nov. 2005 (50(7): 3, 6

# ''Boston Globe,'' "MIT professor is fired over fabricated data," 28 Oct. 200

# Samuel Reich, Eugenie (2005) MIT professor sacked for fabricating data. ''NewScientist.com'' (28 Oct.

# ''New York Times,'' "M.I.T. Dismisses a Researcher, Saying He Fabricated Some Data," 28 Oct. 200

# ''The Tech'' (MIT student paper), "MIT Fires Professor Van Parijs for Using Fake Data in Papers," 28 Oct. 200

# ''Boston Globe,'' "More doubts raised on fired MIT professor," 29 Oct. 200

# ''Harvard Crimson,'' "MIT Professor Fired for Faking Data," 31 Oct. 200

# ''The Tech,'' "Van Parijs’ Research at Caltech, Brigham Drawing New Scrutiny," 1 Nov. 200

# ''TheScientist.com,'' "Immunologists prepare for fraud fallout," 3 Nov. 200

# Dalton, R. (2005) Universities scramble to assess scope of falsified results. ''Nature'' 438(7064): 7 (3 Nov.) # Couzin, J. (2005) MIT terminates researcher over data fabrication. ''Science'' 310(5749): 758 (4 Nov.) # ''New Scientist,'' "One bad apple..." (unsigned editorial), 5 Nov. 200

# ''Chronicle of Higher Education,'' "MIT Fires Biology Professor Who Admitted Faking Data," 11 Nov. 200

(Payment or subscription required.) # unsigned editorial (2006) Scientific blues. ''Nature Immunology'' 7(1): 1 (1 Jan.) # Reich, E.S. (2006) Bad data fail to halt patents. ''Nature'' 439(7075): 379 (26 Jan.) # Odling-Smee, L., Giles, J., Fuyuno, I., Cyranoski, D., & Marris, E. (2007) Misconduct Special: Where are they now? ''Nature'' 445(7125): 244-5 (18 Jan.) # Reich, E.S. (2007) Scientific misconduct report still under wraps. ''New Scientist'' ?(2631): 16 (24 Nov.

# Reich, E.S. (2009) Former MIT biologist penalized for falsifying data. ''Nature.com'' (3 Feb.
Nature News
o
here
# Reich, E.S. (2009) Beating the science cheats. ''New Scientist'' ?(2706): 22 (2 May


See also

* List of scientific misconduct incidents


References


External links


''Science''Insider Former MIT Researcher Convicted of Fraud


* ttp://web.mit.edu/newsoffice/2005/misconduct.html MIT News Office: MIT professor dismissed for research misconduct
PubMed search
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Google Scholar search: L Van Parijs

MIT Center for Cancer Research

Photo of Van Parijs
{{DEFAULTSORT:Van Parijs, Luk 1970 births Living people 21st-century American biologists Academic scandals in the United States Alumni of the University of Cambridge Harvard Medical School alumni People involved in scientific misconduct incidents