Lithium carbonate is an

inorganic compound An inorganic compound is typically a chemical compound that lacks carbon–hydrogen bonds⁠that is, a compound that is not an organic compound. The study of inorganic compounds is a subfield of chemistry known as ''inorganic chemistry''. Inorgan ...

, the lithium salt of

carbonic acid Carbonic acid is a chemical compound with the chemical formula . The molecule rapidly converts to water and carbon dioxide in the presence of water. However, in the absence of water, it is quite stable at room temperature. The interconversion ...

with the

formula In science, a formula is a concise way of expressing information symbolically, as in a mathematical formula or a ''chemical formula''. The informal use of the term ''formula'' in science refers to the general construct of a relationship betwe ...

. This white

salt In common usage, salt is a mineral composed primarily of sodium chloride (NaCl). When used in food, especially in granulated form, it is more formally called table salt. In the form of a natural crystalline mineral, salt is also known as r ...

is widely used in processing metal oxides. It is on the

World Health Organization's List of Essential Medicines The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health s ...

for its efficacy in the treatment of

mood disorder A mood disorder, also known as an affective disorder, is any of a group of conditions of mental and behavioral disorder where the main underlying characteristic is a disturbance in the person's mood. The classification is in the ''Diagnostic ...

s such as

bipolar disorder Bipolar disorder (BD), previously known as manic depression, is a mental disorder characterized by periods of Depression (mood), depression and periods of abnormally elevated Mood (psychology), mood that each last from days to weeks, and in ...

Uses

Lithium carbonate is an important industrial

chemical A chemical substance is a unique form of matter with constant chemical composition and characteristic properties. Chemical substances may take the form of a single element or chemical compounds. If two or more chemical substances can be combin ...

. Its main use is as a precursor to compounds used in lithium-ion batteries. Glasses derived from lithium carbonate are useful in ovenware. Lithium carbonate is a common ingredient in both low-fire and high-fire

ceramic glaze Ceramic glaze, or simply glaze, is a glassy coating on ceramics. It is used for decoration, to ensure the item is impermeable to liquids and to minimize the adherence of pollutants. Glazing renders earthenware impermeable to water, sealing th ...

. It forms low-melting

flux Flux describes any effect that appears to pass or travel (whether it actually moves or not) through a surface or substance. Flux is a concept in applied mathematics and vector calculus which has many applications in physics. For transport phe ...

es with

silica Silicon dioxide, also known as silica, is an oxide of silicon with the chemical formula , commonly found in nature as quartz. In many parts of the world, silica is the major constituent of sand. Silica is one of the most complex and abundant f ...

and other materials. Its

alkaline In chemistry, an alkali (; from the Arabic word , ) is a basic salt of an alkali metal or an alkaline earth metal. An alkali can also be defined as a base that dissolves in water. A solution of a soluble base has a pH greater than 7.0. The ...

properties are conducive to changing the state of metal oxide colorants in glaze, particularly red iron oxide (). Cement sets more rapidly when prepared with lithium carbonate, and is useful for tile

adhesive Adhesive, also known as glue, cement, mucilage, or paste, is any non-metallic substance applied to one or both surfaces of two separate items that binds them together and resists their separation. The use of adhesives offers certain advantage ...

s. When added to

aluminium trifluoride Aluminium fluoride is an inorganic compound with the formula . It forms hydrates . Anhydrous and its hydrates are all colorless solids. Anhydrous is used in the production of aluminium. Several occur as minerals. Occurrence and production Aside ...

, it forms LiF which yields a superior

electrolyte An electrolyte is a substance that conducts electricity through the movement of ions, but not through the movement of electrons. This includes most soluble Salt (chemistry), salts, acids, and Base (chemistry), bases, dissolved in a polar solven ...

for the processing of

aluminium Aluminium (or aluminum in North American English) is a chemical element; it has chemical symbol, symbol Al and atomic number 13. It has a density lower than that of other common metals, about one-third that of steel. Aluminium has ...

Rechargeable batteries

Lithium carbonate-derived compounds are crucial to

lithium-ion batteries A lithium-ion or Li-ion battery is a type of rechargeable battery that uses the reversible intercalation of Li+ ions into electronically conducting solids to store energy. Li-ion batteries are characterized by higher specific energy, energy ...

. Lithium carbonate may be converted into

lithium hydroxide Lithium hydroxide is an inorganic compound with the formula LiOH. It can exist as anhydrous or hydrated, and both forms are white hygroscopic solids. They are soluble in water and slightly soluble in ethanol. Both are available commercially. While ...

as an intermediate. In practice, two components of the battery are made with lithium compounds: the

cathode A cathode is the electrode from which a conventional current leaves a polarized electrical device such as a lead-acid battery. This definition can be recalled by using the mnemonic ''CCD'' for ''Cathode Current Departs''. Conventional curren ...

and the

. The electrolyte is a solution of lithium hexafluorophosphate, while the cathode uses one of several lithiated structures, the most popular of which are lithium cobalt oxide and

lithium iron phosphate Lithium iron phosphate or lithium ferro-phosphate (LFP) is an inorganic compound with the formula . It is a gray, red-grey, brown or black solid that is insoluble in water. The material has attracted attention as a component of lithium iron phosp ...

Medical uses

In 1843, lithium carbonate was used to treat stones in the

bladder The bladder () is a hollow organ in humans and other vertebrates that stores urine from the kidneys. In placental mammals, urine enters the bladder via the ureters and exits via the urethra during urination. In humans, the bladder is a distens ...

. In 1859, some doctors recommended a therapy with lithium

salts In chemistry, a salt or ionic compound is a chemical compound consisting of an assembly of positively charged ions ( cations) and negatively charged ions (anions), which results in a compound with no net electric charge (electrically neutral). ...

for a number of ailments, including

gout Gout ( ) is a form of inflammatory arthritis characterized by recurrent attacks of pain in a red, tender, hot, and Joint effusion, swollen joint, caused by the deposition of needle-like crystals of uric acid known as monosodium urate crysta ...

, urinary calculi,

rheumatism Rheumatism or rheumatic disorders are conditions causing chronic, often intermittent pain affecting the joints or connective tissue. Rheumatism does not designate any specific disorder, but covers at least 200 different conditions, including a ...

mania Mania, also known as manic syndrome, is a Psychiatry, psychiatric Abnormality (behavior), behavioral syndrome defined as a state of Abnormality (behavior), abnormally elevated arousal, affect (psychology), affect, and energy level. During a mani ...

, depression, and

headache A headache, also known as cephalalgia, is the symptom of pain in the face, head, or neck. It can occur as a migraine, tension-type headache, or cluster headache. There is an increased risk of Depression (mood), depression in those with severe ...

. In 1948,

John Cade John Frederick Joseph Cade AO (18 January 1912 – 16 November 1980) was an Australian psychiatrist who in 1948 discovered the effects of lithium carbonate as a mood stabilizer in the treatment of bipolar disorder, then known as manic depressi ...

discovered the anti-manic effects of lithium ions. This finding led to lithium carbonate's use as a

psychiatric medication A psychiatric or psychotropic medication is a psychoactive drug taken to exert an effect on the chemical makeup of the brain and nervous system. Thus, these medications are used to treat mental illnesses. These medications are typically made of ...

to treat mania, the elevated phase of

. Prescription lithium carbonate from a

pharmacy Pharmacy is the science and practice of discovering, producing, preparing, dispensing, reviewing and monitoring medications, aiming to ensure the safe, effective, and affordable use of medication, medicines. It is a miscellaneous science as it ...

is suitable for use as medicine in humans but industrial lithium carbonate is not since it may contain unsafe levels of toxic heavy metals or other

toxicant A toxicant is any toxic substance, whether artificial or naturally occurring. By contrast, a toxin is a poison produced naturally by an organism (e.g. plant, animal, insect, bacterium). The different types of toxicants can be found in the air, so ...

s. After ingestion, lithium carbonate is dissociated into pharmacologically active

lithium Lithium (from , , ) is a chemical element; it has chemical symbol, symbol Li and atomic number 3. It is a soft, silvery-white alkali metal. Under standard temperature and pressure, standard conditions, it is the least dense metal and the ...

ions (Li⁺) and (non-therapeutic)

carbonate A carbonate is a salt of carbonic acid, (), characterized by the presence of the carbonate ion, a polyatomic ion with the formula . The word "carbonate" may also refer to a carbonate ester, an organic compound containing the carbonate group ...

, with 300 mg of lithium carbonate containing approximately 8 mEq (8 mmol) of lithium ion. According to the

Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is respo ...

(FDA), 300–600 mg of lithium carbonate taken two to three times daily is typical for maintenance of bipolar I disorder in adults, where the exact dose given varies depending on factors such as the patient's serum lithium concentrations, which must be closely monitored by a

physician A physician, medical practitioner (British English), medical doctor, or simply doctor is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through the Medical education, study, Med ...

to avoid lithium toxicity and potential kidney damage (or even

kidney failure Kidney failure, also known as renal failure or end-stage renal disease (ESRD), is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney fa ...

) from lithium-induced nephrogenic diabetes insipidus.

Dehydration In physiology, dehydration is a lack of total body water that disrupts metabolic processes. It occurs when free water loss exceeds intake, often resulting from excessive sweating, health conditions, or inadequate consumption of water. Mild deh ...

and certain drugs, including NSAIDs such as

ibuprofen Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, fever, and inflammation. This includes dysmenorrhea, painful menstrual periods, migraines, and rheumatoid arthritis. It can be taken oral administration, ...

, can increase serum lithium concentrations to unsafe levels whereas other drugs, such as

caffeine Caffeine is a central nervous system (CNS) stimulant of the methylxanthine chemical classification, class and is the most commonly consumed Psychoactive drug, psychoactive substance globally. It is mainly used for its eugeroic (wakefulness pr ...

, may decrease concentrations. In contrast to the elemental ions

sodium Sodium is a chemical element; it has Symbol (chemistry), symbol Na (from Neo-Latin ) and atomic number 11. It is a soft, silvery-white, highly reactive metal. Sodium is an alkali metal, being in group 1 element, group 1 of the peri ...

potassium Potassium is a chemical element; it has Symbol (chemistry), symbol K (from Neo-Latin ) and atomic number19. It is a silvery white metal that is soft enough to easily cut with a knife. Potassium metal reacts rapidly with atmospheric oxygen to ...

, and

calcium Calcium is a chemical element; it has symbol Ca and atomic number 20. As an alkaline earth metal, calcium is a reactive metal that forms a dark oxide-nitride layer when exposed to air. Its physical and chemical properties are most similar to it ...

, there is no known cellular mechanism specifically dedicated to regulating

intracellular This glossary of biology terms is a list of definitions of fundamental terms and concepts used in biology, the study of life and of living organisms. It is intended as introductory material for novices; for more specific and technical definitions ...

lithium. Lithium can enter cells through epithelial sodium channels. Lithium ions interfere with ion transport processes that relay and amplify messages carried to the cells of the brain. Mania is associated with irregular increases in

protein kinase C In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and t ...

(PKC) activity within the brain. Lithium carbonate and sodium valproate, another drug conventionally used to treat the disorder, act in the brain by inhibiting PKC's activity and help to produce other compounds that also inhibit the PKC. Lithium carbonate's mood-controlling properties are not fully understood.

Health risks

Taking lithium salts has risks and side effects. Extended use of lithium to treat mental disorders has been known to lead to acquired nephrogenic diabetes insipidus. Lithium intoxication can affect the

central nervous system The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain, spinal cord and retina. The CNS is so named because the brain integrates the received information and coordinates and influences the activity o ...

and

renal system The human urinary system, also known as the urinary tract or renal system, consists of the kidneys, ureters, bladder, and the urethra. The purpose of the urinary system is to eliminate waste from the body, regulate blood volume and blood pressu ...

and can be lethal. Over a prolonged period, lithium can accumulate in the principal cells of the collecting duct and interfere with

antidiuretic hormone Mammalian vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the ''AVP'' gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It ...

(ADH), which regulates the water permeability of principal cells in the collecting tubule. The medullary interstitium of the

collecting duct system The collecting duct system of the kidney consists of a series of tubules and ducts that physically connect nephrons to a minor calyx or directly to the renal pelvis. The collecting duct participates in electrolyte and fluid balance through rea ...

naturally has a high sodium concentration and attempts to maintain it. There is no known mechanism for cells to distinguish lithium ions from sodium ions, so damage to the

kidney In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organ (anatomy), organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation. They are located on the left and rig ...

nephron The nephron is the minute or microscopic structural and functional unit of the kidney. It is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a glomerulus and a cup-shaped structu ...

s may occur if lithium concentrations become too high as a result of

dehydration In physiology, dehydration is a lack of total body water that disrupts metabolic processes. It occurs when free water loss exceeds intake, often resulting from excessive sweating, health conditions, or inadequate consumption of water. Mild deh ...

hyponatremia Hyponatremia or hyponatraemia is a low concentration of sodium in the Serum (blood), blood. It is generally defined as a sodium concentration of less than 135 mmol/L (135 mEq/L), with severe hyponatremia being below 120 mEq/L. Symp ...

, an unusually low sodium diet, or certain drugs.

Red pyrotechnic colorant

Lithium carbonate is used to impart a red color to fireworks.

Properties and reactions

Unlike

sodium carbonate Sodium carbonate (also known as washing soda, soda ash, sal soda, and soda crystals) is the inorganic compound with the formula and its various hydrates. All forms are white, odourless, water-soluble salts that yield alkaline solutions in water ...

, which forms at least three

hydrates In chemistry, a hydrate is a substance that contains water or its constituent elements. The chemical state of the water varies widely between different classes of hydrates, some of which were so labeled before their chemical structure was understo ...

, lithium carbonate exists only in the anhydrous form. Its solubility in water is low relative to other lithium salts. The isolation of lithium from aqueous extracts of lithium

ore Ore is natural rock or sediment that contains one or more valuable minerals, typically including metals, concentrated above background levels, and that is economically viable to mine and process. The grade of ore refers to the concentration ...

s capitalizes on this poor solubility. Its apparent solubility increases 10-fold under a mild pressure of

carbon dioxide Carbon dioxide is a chemical compound with the chemical formula . It is made up of molecules that each have one carbon atom covalent bond, covalently double bonded to two oxygen atoms. It is found in a gas state at room temperature and at norma ...

; this effect is due to the formation of the

metastable In chemistry and physics, metastability is an intermediate energetic state within a dynamical system other than the system's state of least energy. A ball resting in a hollow on a slope is a simple example of metastability. If the ball is onl ...

lithium bicarbonate, which is more soluble: : + + 2 The extraction of lithium carbonate at high pressures of and its precipitation upon depressurizing is the basis of the Quebec process. Lithium carbonate can also be purified by exploiting its diminished solubility in hot water. Thus, heating a saturated aqueous solution causes crystallization of . Lithium carbonate, and other carbonates of

group 1 Group 1 may refer to: * Alkali metal, a chemical element classification for Alkali metal * Group 1 (motorsport), a regulation set of the FIA for series-production touring cars used in motorsport. * Group One Thoroughbred horse races, the leading e ...

, do not decarboxylate readily. decomposes at temperatures around 1300 °C.

Production

Lithium is extracted from primarily two sources: spodumene in

pegmatite A pegmatite is an igneous rock showing a very coarse texture, with large interlocking crystals usually greater in size than and sometimes greater than . Most pegmatites are composed of quartz, feldspar, and mica, having a similar silicic c ...

deposits, and lithium salts in underground brine pools. About 82,000 tons were produced in 2020, showing significant and consistent growth.

From underground brine reservoirs

In the

Salar de Atacama Salar de Atacama, located south of San Pedro de Atacama, is the largest Salt pan (geology), salt flat in Chile. It is surrounded by mountains and lacks drainage outlets. To the east, it is enclosed by the main chain of the Andes, while to the wes ...

in the

Atacama Desert The Atacama Desert () is a desert plateau located on the Pacific Ocean, Pacific coast of South America, in the north of Chile. Stretching over a strip of land west of the Andes Mountains, it covers an area of , which increases to if the barre ...

of Northern Chile, lithium carbonate and hydroxide are produced from brine. The process pumps lithium rich brine from below ground into shallow pans for evaporation. The brine contains many different dissolved ions, and as their concentration increases, salts precipitate out of solution and sink. The remaining supernatant liquid is used for the next step. The sequence of pans may vary depending on the concentration of ions in a particular source of brine. In the first pan,

halite Halite ( ), commonly known as rock salt, is a type of salt, the mineral (natural) form of sodium chloride ( Na Cl). Halite forms isometric crystals. The mineral is typically colorless or white, but may also be light blue, dark blue, purple, pi ...

(sodium chloride or common salt) crystallises. This has little economic value and is discarded. The supernatant, with ever increasing concentration of dissolved solids, is transferred successively to the

sylvinite Sylvinite is a sedimentary rock made of a mechanical mixture of the minerals sylvite (KCl, or potassium chloride) and halite (NaCl, or sodium chloride).Weiss N.L., SME Mineral Processing Handbook 1985, Page 22-2 Sylvinite is the most important s ...

(sodium potassium chloride) pan, the carnalite (potassium magnesium chloride) pan and finally a pan designed to maximise the concentration of lithium chloride. The process takes about 15 months. The concentrate (30-35% lithium chloride solution) is trucked to Salar del Carmen. There,

boron Boron is a chemical element; it has symbol B and atomic number 5. In its crystalline form it is a brittle, dark, lustrous metalloid; in its amorphous form it is a brown powder. As the lightest element of the boron group it has three ...

and magnesium are removed (typically residual boron is removed by solvent extraction and/or

ion exchange Ion exchange is a reversible interchange of one species of ion present in an insoluble solid with another of like charge present in a solution surrounding the solid. Ion exchange is used in softening or demineralizing of water, purification of ch ...

and magnesium by raising the pH above 10 with

sodium hydroxide Sodium hydroxide, also known as lye and caustic soda, is an inorganic compound with the formula . It is a white solid ionic compound consisting of sodium cations and hydroxide anions . Sodium hydroxide is a highly corrosive base (chemistry), ...

) then in the final step, by addition of

, the desired lithium carbonate is precipitated out, separated, and processed. Some of the by-products from the evaporation process may also have economic value. There is considerable attention to the use of water in this water poor region. SQM commissioned a

life-cycle analysis Life cycle assessment (LCA), also known as life cycle analysis, is a methodology for assessing the impacts associated with all the stages of the life cycle of a commercial product, process, or service. For instance, in the case of a manufact ...

(LCA) which concluded that water consumption for SQM's lithium hydroxide and carbonate is significantly lower than the average consumption by production from the main ore-based process, using spodumene. A more general LCA suggests the opposite for extraction from reservoirs. The majority of brine based production is in the " lithium triangle" in South America.

From "geothermal" brine

A potential source of lithium is the leachates of geothermal wells, carried to the surface.Parker, Ann
Mining Geothermal Resources
. Lawrence Livermore National Laboratory Recovery of lithium has been demonstrated in the field; the lithium is separated by simple precipitation and filtration.Patel, P. (16 November 2011
Startup to Capture Lithium from Geothermal Plants
. technologyreview.com The process and environmental costs are primarily those of the already-operating well; net environmental impacts may thus be positive.Wald, M. (28 September 2011

. The New York Times The brine of United Downs Deep Geothermal Power project near

Redruth Redruth ( , ) is a town and civil parishes in Cornwall, civil parish in Cornwall, England, United Kingdom. According to the 2011 census, the population of Redruth was 14,018 In the same year the population of the Camborne-Redruth urban area, ...

is claimed by Cornish Lithium to be valuable due to its high lithium concentration (220 mg/L) with low magnesium (<5 mg/L) and total dissolved solids content of <29g/L, and a flow rate of 40-60l/s.

From ore

α-spodumene is roasted at 1100 °C for 1h to make β-spodumene, then roasted at 250 °C for 10 minutes with sulphuric acid. As of 2020, Australia was the world's largest producer of lithium intermediates, all based on spodumene. In recent years mining companies have begun exploration of

projects throughout

North America North America is a continent in the Northern Hemisphere, Northern and Western Hemisphere, Western hemispheres. North America is bordered to the north by the Arctic Ocean, to the east by the Atlantic Ocean, to the southeast by South Ameri ...

South America South America is a continent entirely in the Western Hemisphere and mostly in the Southern Hemisphere, with a considerably smaller portion in the Northern Hemisphere. It can also be described as the southern Subregion#Americas, subregion o ...

and

Australia Australia, officially the Commonwealth of Australia, is a country comprising mainland Australia, the mainland of the Australia (continent), Australian continent, the island of Tasmania and list of islands of Australia, numerous smaller isl ...

to identify economic deposits that can potentially bring new supplies of lithium carbonate online to meet the growing demand for the product.

From clay

In 2020

Tesla Motors Tesla, Inc. ( or ) is an American multinational automotive and clean energy company. Headquartered in Austin, Texas, it designs, manufactures and sells battery electric vehicles (BEVs), stationary battery energy storage devices from hom ...

announced a revolutionary process to extract lithium from clay in Nevada using only salt and no acid. This was met with scepticism.

From end-of-life batteries

A few small companies are recycling spent batteries, focusing on recovering copper and cobalt. Some recover lithium carbonate alongside the compound Li₂Al₄(CO₃)(OH)₁₂⋅3H₂O also.

Other

In April 2017 MGX Minerals reported it had received independent confirmation of its rapid

extraction process to recover lithium and other valuable minerals from

oil and gas A fossil fuel is a flammable carbon compound- or hydrocarbon-containing material formed naturally in the Earth's crust from the buried remains of prehistoric organisms (animals, plants or microplanktons), a process that occurs within geologi ...

wastewater

brine Brine (or briny water) is a high-concentration solution of salt (typically sodium chloride or calcium chloride) in water. In diverse contexts, ''brine'' may refer to the salt solutions ranging from about 3.5% (a typical concentration of seawat ...

Electrodialysis Electrodialysis (ED) is used to transport salt ions from one solution through ion-exchange membranes to another solution under the influence of an applied electric potential difference. This is done in a configuration called an electrodialysis ...

has been proposed to extract lithium from seawater, but it is not commercially viable.

Natural occurrence

Natural lithium carbonate is known as zabuyelite. This mineral is connected with deposits of some

salt lake A salt lake or saline lake is a landlocked body of water that has a concentration of salts (typically sodium chloride) and other dissolved minerals significantly higher than most lakes (often defined as at least three grams of salt per liter). I ...

s and some

References

External links

{{Authority control Carbonates Lithium salts Mood stabilizers Orphan drugs World Health Organization essential medicines