Lex Cools
   HOME

TheInfoList



OR:

Alexander ("Lex") Rudolf Cools (1941 in
The Hague The Hague ( ) is the capital city of the South Holland province of the Netherlands. With a population of over half a million, it is the third-largest city in the Netherlands. Situated on the west coast facing the North Sea, The Hague is the c ...
– 7 September 2013 in
Nijmegen Nijmegen ( , ; Nijmeegs: ) is the largest city in the Dutch province of Gelderland and the ninth largest of the Netherlands as a whole. Located on the Waal River close to the German border, Nijmegen is one of the oldest cities in the ...
) was a Dutch behavioral pharmacologist. He obtained his Ph.D. under the supervision of Jacques van Rossum and Jo Vossen in 1973 at the
Radboud University Nijmegen Radboud University (abbreviated as RU, , formerly ) is a public university, public research university located in Nijmegen, Netherlands. RU has seven faculties and more than 24,000 students. Established in 1923, Radboud University has consistentl ...
, where he was a
professor Professor (commonly abbreviated as Prof.) is an Academy, academic rank at university, universities and other tertiary education, post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin ...
from 1985 until his retirement in 2006. In 2014, a special issue of the
scientific journal In academic publishing, a scientific journal is a periodical publication designed to further the progress of science by disseminating new research findings to the scientific community. These journals serve as a platform for researchers, schola ...
''
Behavioural Pharmacology Behavior (American English) or behaviour (British English) is the range of actions of individuals, organisms, systems or artificial entities in some environment. These systems can include other systems or organisms as well as the inanimate ph ...
'' was dedicated to his memory. Cools was one of the founders of the European Behavioural Pharmacology Society and its second president. In 2003 he received that society's Distinguished Achievement Award. In 1976, Cools was the first to propose the existence of different types of
dopamine receptor Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Dopamine receptors activate different effectors through not only G-protein coupling, but also signaling through diff ...
s, an essentially correct claim that initially was generally dismissed. Besides his work on
dopamine Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. It is an amine synthesized ...
, Cools is mostly known for his work on the
basal ganglia The basal ganglia (BG) or basal nuclei are a group of subcortical Nucleus (neuroanatomy), nuclei found in the brains of vertebrates. In humans and other primates, differences exist, primarily in the division of the globus pallidus into externa ...
and the dorsal and ventral
striatum The striatum (: striata) or corpus striatum is a cluster of interconnected nuclei that make up the largest structure of the subcortical basal ganglia. The striatum is a critical component of the motor and reward systems; receives glutamat ...
.


References


External links

* Radboud University Nijmegen alumni Academic staff of Radboud University Nijmegen Dutch neuroscientists Health professionals from The Hague 1941 births 2013 deaths {{academic-stub