Legonmycins are a group of chemical compounds that belong to the
pyrrolizidine family of naturally occurring
alkaloid
Alkaloids are a broad class of natural product, naturally occurring organic compounds that contain at least one nitrogen atom. Some synthetic compounds of similar structure may also be termed alkaloids.
Alkaloids are produced by a large varie ...
s. Discovered by a joint team of researchers from
University of Ghana
The University of Ghana is a public university located in Accra, Ghana. It is the oldest public university in the country.
The university was founded in 1948 as the University College of the Gold Coast in the British colony of the Gold Coast ...
,
University of Aberdeen
The University of Aberdeen (abbreviated ''Aberd.'' in List of post-nominal letters (United Kingdom), post-nominals; ) is a public university, public research university in Aberdeen, Scotland. It was founded in 1495 when William Elphinstone, Bis ...
, and
Wuhan University
Wuhan University (WHU; 武汉大学) is a key comprehensive public university in Wuhan, Hubei, China. It is directly affiliated with and funded by the Ministry of Education of the People's Republic of China, Ministry of Education of China. The un ...
, the compounds were isolated from ''
Streptomyces
''Streptomyces'', from στρεπτός (''streptós''), meaning "twisted", and μύκης (''múkés''), meaning "fungus", is the largest genus of Actinomycetota, and the type genus of the family Streptomycetaceae. Over 700 species of ''St ...
'' microorganisms in
Legon
Legon , a suburb of the Ghanaian city Accra, is situated about north-east of the city center in the Ayawaso West Municipal District, a district in the Greater Accra Region of Ghana. Legon is home to the main campus of the University of Ghana. ...
, a suburb of
Accra, Ghana
Accra (; or ''Gaga''; ; Ewe: Gɛ; ) is the capital and largest city of Ghana, located on the southern coast at the Gulf of Guinea, which is part of the Atlantic Ocean. As of 2021 census, the Accra Metropolitan District, , had a population ...
.
Laboratory syntheses of legonmycin A and legonmycin B have been reported.
References
Pyrrolizidine alkaloids
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