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A laboratory (; ; colloquially lab) is a facility that provides controlled conditions in which
scientific Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earliest archeological evidence ...
or technological research,
experiment An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs wh ...
s, and measurement may be performed. Laboratory services are provided in a variety of settings: physicians' offices, clinics, hospitals, and regional and national referral centers.


Overview

The organisation and contents of laboratories are determined by the differing requirements of the specialists working within. A
physics Physics is the natural science that studies matter, its fundamental constituents, its motion and behavior through space and time, and the related entities of energy and force. "Physical science is that department of knowledge which rel ...
laboratory might contain a
particle accelerator A particle accelerator is a machine that uses electromagnetic fields to propel electric charge, charged particles to very high speeds and energies, and to contain them in well-defined particle beam, beams. Large accelerators are used for fun ...
or
vacuum chamber A vacuum chamber is a rigid enclosure from which air and other gases are removed by a vacuum pump. This results in a low-pressure environment within the chamber, commonly referred to as a vacuum. A vacuum environment allows researchers to con ...
, while a
metallurgy Metallurgy is a domain of materials science and engineering that studies the physical and chemical behavior of metallic elements, their inter-metallic compounds, and their mixtures, which are known as alloys. Metallurgy encompasses both the sci ...
laboratory could have apparatus for
casting Casting is a manufacturing process in which a liquid material is usually poured into a mold, which contains a hollow cavity of the desired shape, and then allowed to solidify. The solidified part is also known as a ''casting'', which is ejected ...
or
refining {{Unreferenced, date=December 2009 Refining (also perhaps called by the mathematical term affining) is the process of purification of a (1) substance or a (2) form. The term is usually used of a natural resource that is almost in a usable form, b ...
metals or for testing their
strength Strength may refer to: Physical strength *Physical strength, as in people or animals *Hysterical strength, extreme strength occurring when people are in life-and-death situations *Superhuman strength, great physical strength far above human ca ...
. A
chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe ...
or
biologist A biologist is a scientist who conducts research in biology. Biologists are interested in studying life on Earth, whether it is an individual cell, a multicellular organism, or a community of interacting populations. They usually speciali ...
might use a
wet laboratory A wet lab, or experimental lab, is a type of laboratory where it is necessary to handle various types of chemicals and potential "wet" hazards, so the room has to be carefully designed, constructed, and controlled to avoid spillage and contamination ...
, while a psychologist's laboratory might be a room with one-way mirrors and hidden cameras in which to observe behavior. In some laboratories, such as those commonly used by
computer scientist A computer scientist is a person who is trained in the academic study of computer science. Computer scientists typically work on the theoretical side of computation, as opposed to the hardware side on which computer engineers mainly focus ( ...
s, computers (sometimes supercomputers) are used for either
simulations A simulation is the imitation of the operation of a real-world process or system over time. Simulations require the use of Conceptual model, models; the model represents the key characteristics or behaviors of the selected system or proc ...
or the
analysis Analysis ( : analyses) is the process of breaking a complex topic or substance into smaller parts in order to gain a better understanding of it. The technique has been applied in the study of mathematics and logic since before Aristotle (3 ...
of
data In the pursuit of knowledge, data (; ) is a collection of discrete values that convey information, describing quantity, quality, fact, statistics, other basic units of meaning, or simply sequences of symbols that may be further interpret ...
. Scientists in other fields will still use other types of laboratories.
Engineers Engineers, as practitioners of engineering, are professionals who Invention, invent, design, analyze, build and test machines, complex systems, structures, gadgets and materials to fulfill functional objectives and requirements while considerin ...
use laboratories as well to design, build, and test technological devices. Scientific laboratories can be found as research room and
learning space Learning space or learning setting refers to a physical setting for a learning environment, a place in which teaching and learning occur. The term is commonly used as a more definitive alternative to " classroom," but it may also refer to ...
s in
school A school is an educational institution designed to provide learning spaces and learning environments for the teaching of students under the direction of teachers. Most countries have systems of formal education, which is sometimes compu ...
s and
universities A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. ''University'' is derived from the Latin phrase ''universitas magistrorum et scholarium'', which ...
,
industry Industry may refer to: Economics * Industry (economics), a generally categorized branch of economic activity * Industry (manufacturing), a specific branch of economic activity, typically in factories with machinery * The wider industrial sector ...
,
government A government is the system or group of people governing an organized community, generally a state. In the case of its broad associative definition, government normally consists of legislature, executive, and judiciary. Government ...
, or
military A military, also known collectively as armed forces, is a heavily armed, highly organized force primarily intended for warfare. It is typically authorized and maintained by a sovereign state, with its members identifiable by their distin ...
facilities, and even aboard
ship A ship is a large watercraft that travels the world's oceans and other sufficiently deep waterways, carrying cargo or passengers, or in support of specialized missions, such as defense, research, and fishing. Ships are generally distinguishe ...
s and
spacecraft A spacecraft is a vehicle or machine designed to spaceflight, fly in outer space. A type of artificial satellite, spacecraft are used for a variety of purposes, including Telecommunications, communications, Earth observation satellite, Earth ...
. Despite the underlying notion of the lab as a confined space for experts, the term "laboratory" is also increasingly applied to workshop spaces such as
Living Labs Living or The Living may refer to: Common meanings *Life, a condition that distinguishes organisms from inorganic objects and dead organisms ** Living species, one that is not extinct * Personal life, the course of an individual human's life * H ...
, Fab Labs, or
Hackerspace A hackerspace (also referred to as a hacklab, hackspace, or makerspace) is a community-operated, often "not for profit" ( 501(c)(3) in the United States), workspace where people with common interests, such as computers, machining, technology ...
s, in which people meet to work on societal problems or make prototypes, working collaboratively or sharing resources. This development is inspired by new, participatory approaches to science and innovation and relies on user-centred design methods and concepts like
Open innovation Open innovation is a term used to promote an information age mindset toward innovation that runs counter to the secrecy#Computing, secrecy and information silo, silo mentality of traditional corporate research labs. The benefits and driving force ...
or
User innovation __NOTOC__ User innovation refers to innovation by intermediate users (e.g. user firms) or consumer users (individual end-users or user communities), rather than by suppliers (producers or manufacturers). This is a concept closely aligned to co-d ...
,. One distinctive feature of work in Open Labs is the phenomenon of
translation Translation is the communication of the Meaning (linguistic), meaning of a #Source and target languages, source-language text by means of an Dynamic and formal equivalence, equivalent #Source and target languages, target-language text. The ...
, driven by the different backgrounds and levels of expertise of the people involved.


History

Early instances of "laboratories" recorded in English involved
alchemy Alchemy (from Arabic: ''al-kīmiyā''; from Ancient Greek: χυμεία, ''khumeía'') is an ancient branch of natural philosophy, a philosophical and protoscientific tradition that was historically practiced in China, India, the Muslim world ...
and the preparation of
medicine Medicine is the science and Praxis (process), practice of caring for a patient, managing the diagnosis, prognosis, Preventive medicine, prevention, therapy, treatment, Palliative care, palliation of their injury or disease, and Health promotion ...
s. The emergence of Big Science during
World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the World War II by country, vast majority of the world's countries—including all of the great power ...
increased the size of laboratories and scientific equipment, introducing
particle accelerator A particle accelerator is a machine that uses electromagnetic fields to propel electric charge, charged particles to very high speeds and energies, and to contain them in well-defined particle beam, beams. Large accelerators are used for fun ...
s and similar devices.


The early laboratories

The earliest laboratory according to the present evidence is a home laboratory of
Pythagoras Pythagoras of Samos ( grc, Πυθαγόρας ὁ Σάμιος, Pythagóras ho Sámios, Pythagoras the Samian, or simply ; in Ionian Greek; ) was an ancient Ionian Greek philosopher and the eponymous founder of Pythagoreanism. His politic ...
of Samos, the well-known Greek philosopher and scientist. This laboratory was created when
Pythagoras Pythagoras of Samos ( grc, Πυθαγόρας ὁ Σάμιος, Pythagóras ho Sámios, Pythagoras the Samian, or simply ; in Ionian Greek; ) was an ancient Ionian Greek philosopher and the eponymous founder of Pythagoreanism. His politic ...
conducted an experiment about tones of sound and vibration of string. In the painting of
Louis Pasteur Louis Pasteur (, ; 27 December 1822 – 28 September 1895) was a French chemist and microbiologist renowned for his discoveries of the principles of vaccination, microbial fermentation and pasteurization, the latter of which was named after ...
by
Albert Edelfelt Albert Gustaf Aristides Edelfelt (21 July 1854 – 18 August 1905) was a Finnish-Swedish painter noted for his naturalistic style and Realist approach to art. He lived in the Grand Duchy of Finland and made Finnish culture visible abroad, befor ...
in 1885,
Louis Pasteur Louis Pasteur (, ; 27 December 1822 – 28 September 1895) was a French chemist and microbiologist renowned for his discoveries of the principles of vaccination, microbial fermentation and pasteurization, the latter of which was named after ...
is shown comparing a note in his left hand with a bottle filled with a solid in his right hand, and not wearing any
personal protective equipment Personal protective equipment (PPE) is protective clothing, helmets, goggles, or other garments or equipment designed to protect the wearer's body from injury or infection. The hazards addressed by protective equipment include physical, ...
. Researching in teams started in the 19th century, and many new kinds of equipment were developed in the 20th century. A 16th century underground alchemical laboratory was accidentally discovered in the year 2002.
Rudolf II, Holy Roman Emperor Rudolf II (18 July 1552 – 20 January 1612) was Holy Roman Emperor (1576–1612), King of Hungary and Croatia (as Rudolf I, 1572–1608), King of Bohemia (1575–1608/1611) and Archduke of Austria (1576–1608). He was a member of the H ...
was believed to be the owner. The laboratory is called Speculum Alchemiae and is preserved as a museum in
Prague Prague ( ; cs, Praha ; german: Prag, ; la, Praga) is the capital and largest city in the Czech Republic, and the historical capital of Bohemia. On the Vltava river, Prague is home to about 1.3 million people. The city has a temperate ...
. File:Chemielabor des 18. Jahrhunderts, Naturhistorisches Museum Wien.jpg, Chemistry laboratory of the 18th century, of the sort used by
Antoine Lavoisier Antoine-Laurent de Lavoisier ( , ; ; 26 August 17438 May 1794),
CNRS ( Thomas Edison Thomas Alva Edison (February 11, 1847October 18, 1931) was an American inventor and businessman. He developed many devices in fields such as electric power generation, mass communication, sound recording, and motion pictures. These invent ...
in his laboratory, 1901 File:Kulutusosuuskuntien Keskusliiton kokoelma D1974 11365A (30257239153).jpg, A laboratory of the Chemistry Department of the
University of Helsinki The University of Helsinki ( fi, Helsingin yliopisto, sv, Helsingfors universitet, abbreviated UH) is a public research university located in Helsinki, Finland since 1829, but founded in the city of Turku (in Swedish ''Åbo'') in 1640 as the ...
on September 23, 1960 File:Fotothek df n-09 0000024.jpg, A laboratory in the 1970s File:MUIC chem lab.jpg, Chemical laboratory in
Mahidol University International College Mahidol University International College (MUIC; th, วิทยาลัยนานาชาติ มหาวิทยาลัยมหิดล) is Thailand's first public international college. It is part of Mahidol University and is loc ...
since 2009 File:Muic counter in lab chem.jpg, Early 2000s style of counter in Chemical Laboratory,
Mahidol University International College Mahidol University International College (MUIC; th, วิทยาลัยนานาชาติ มหาวิทยาลัยมหิดล) is Thailand's first public international college. It is part of Mahidol University and is loc ...
,
Thailand Thailand ( ), historically known as Siam () and officially the Kingdom of Thailand, is a country in Southeast Asia, located at the centre of the Indochinese Peninsula, spanning , with a population of almost 70 million. The country is b ...
File:Chemisches Labor.jpg, Laboratory for organic Chemistry at the University of Applied Science Aachen, Campus Jülich,
Germany Germany, officially the Federal Republic of Germany (FRG),, is a country in Central Europe. It is the most populous member state of the European Union. Germany lies between the Baltic and North Sea to the north and the Alps to the sou ...


Techniques

Laboratory techniques are the set of procedures used on
natural sciences Natural science is one of the branches of science concerned with the description, understanding and prediction of natural phenomena, based on empirical evidence from observation and experimentation. Mechanisms such as peer review and repeat ...
such as chemistry,
biology Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditar ...
,
physics Physics is the natural science that studies matter, its fundamental constituents, its motion and behavior through space and time, and the related entities of energy and force. "Physical science is that department of knowledge which rel ...
to conduct an experiment, all of them follow the
scientific method The scientific method is an Empirical evidence, empirical method for acquiring knowledge that has characterized the development of science since at least the 17th century (with notable practitioners in previous centuries; see the article hist ...
; while some of them involve the use of complex laboratory equipment from
laboratory glassware Laboratory glassware refers to a variety of equipment used in scientific work, and traditionally made of glass. Glass can be blown, bent, cut, molded, and formed into many sizes and shapes, and is therefore common in chemistry, biology, and ana ...
to electrical devices, and others require more specific or expensive supplies.


Equipment and supplies

Laboratory equipment refers to the various tools and equipment used by scientists working in a laboratory: The classical equipment includes tools such as
Bunsen burner A Bunsen burner, named after Robert Bunsen, is a kind of ambient air gas burner used as laboratory equipment; it produces a single open gas flame, and is used for heating, sterilization, and combustion. The gas can be natural gas (which is ma ...
s and
microscope A microscope () is a laboratory instrument used to examine objects that are too small to be seen by the naked eye. Microscopy is the science of investigating small objects and structures using a microscope. Microscopic means being invisibl ...
s as well as specialty equipment such as
operant conditioning chamber An operant conditioning chamber (also known as a Skinner box) is a laboratory apparatus used to study animal behavior. The operant conditioning chamber was created by B. F. Skinner while he was a graduate student at Harvard University. The ch ...
s, spectrophotometers and
calorimeter A calorimeter is an object used for calorimetry, or the process of measuring the heat of chemical reactions or physical changes as well as heat capacity. Differential scanning calorimeters, isothermal micro calorimeters, titration calorimete ...
s. ;Chemical laboratories *
laboratory glassware Laboratory glassware refers to a variety of equipment used in scientific work, and traditionally made of glass. Glass can be blown, bent, cut, molded, and formed into many sizes and shapes, and is therefore common in chemistry, biology, and ana ...
such as the beaker or
reagent bottle Reagent bottles, also known as media bottles or graduated bottles, are containers made of glass, plastic, borosilicate or related substances, and topped by special caps or stoppers. They are intended to contain chemicals in liquid A liquid i ...
* Analytical devices as
HPLC High-performance liquid chromatography (HPLC), formerly referred to as high-pressure liquid chromatography, is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to pa ...
or
spectrophotometers Spectrophotometry is a branch of electromagnetic spectroscopy concerned with the quantitative measurement of the reflection or transmission properties of a material as a function of wavelength. Spectrophotometry uses photometers, known as spe ...
;Molecular biology laboratories + Life science laboratories *
Autoclave An autoclave is a machine used to carry out industrial and scientific processes requiring elevated temperature and pressure in relation to ambient pressure and/or temperature. Autoclaves are used before surgical procedures to perform steriliza ...
*
Microscope A microscope () is a laboratory instrument used to examine objects that are too small to be seen by the naked eye. Microscopy is the science of investigating small objects and structures using a microscope. Microscopic means being invisibl ...
*
Centrifuges A centrifuge is a device that uses centrifugal force to separate various components of a fluid. This is achieved by spinning the fluid at high speed within a container, thereby separating fluids of different densities (e.g. cream from milk) or ...
* Shakers & mixers *
Pipette A pipette (sometimes spelled as pipett) is a laboratory tool commonly used in chemistry, biology and medicine to transport a measured volume of liquid, often as a media dispenser. Pipettes come in several designs for various purposes with dif ...
*
Thermal cyclers The thermal cycler (also known as a thermocycler, PCR machine or DNA amplifier) is a laboratory apparatus most commonly used to amplify segments of DNA via the polymerase chain reaction (PCR). Thermal cyclers may also be used in laboratories to ...
(
PCR PCR or pcr may refer to: Science * Phosphocreatine, a phosphorylated creatine molecule * Principal component regression, a statistical technique Medicine * Polymerase chain reaction ** COVID-19 testing, often performed using the polymerase chain r ...
) *
Photometer A photometer is an instrument that measures the strength of electromagnetic radiation in the range from ultraviolet to infrared and including the visible spectrum. Most photometers convert light into an electric current using a photoresistor, ...
* Refrigerators and Freezers *
Universal testing machine A universal testing machine (UTM), also known as a universal tester, materials testing machine or materials test frame, is used to test the tensile strength and compressive strength of materials. An earlier name for a tensile testing machine ...
* ULT Freezers * Incubators *
Bioreactor A bioreactor refers to any manufactured device or system that supports a biologically active environment. In one case, a bioreactor is a vessel in which a chemical process is carried out which involves organisms or biochemically active substances ...
* Biological safety cabinets *
Sequencing In genetics and biochemistry, sequencing means to determine the primary structure (sometimes incorrectly called the primary sequence) of an unbranched biopolymer. Sequencing results in a symbolic linear depiction known as a sequence which succi ...
instruments *
Fume hoods A fume hood (sometimes called a fume cupboard or fume closet) is a type of local ventilation device that is designed to limit exposure to hazardous or toxic fumes, vapors or dusts. Description A fume hood is typically a large piece of equipme ...
*
Environmental chamber An environmental chamber, also called a climatic chamber or climate chamber, is an enclosure used to test the effects of specified environmental conditions on biological items, industrial products, materials, and electronic devices and components ...
*
Humidifier A humidifier is a device, primarily an electrical appliance, that increases humidity (moisture) in a single room or an entire building. In the home, point-of-use humidifiers are commonly used to humidify a single room, while whole-house or furna ...
*
Weighing scale A scale or balance is a device used to measure weight or mass. These are also known as mass scales, weight scales, mass balances, and weight balances. The traditional scale consists of two plates or bowls suspended at equal distances from ...
*
Reagents In chemistry, a reagent ( ) or analytical reagent is a substance or compound added to a system to cause a chemical reaction, or test if one occurs. The terms ''reactant'' and ''reagent'' are often used interchangeably, but reactant specifies a ...
(supply) * Pipettes tips (supply) *
Polymer A polymer (; Greek ''poly-'', "many" + '' -mer'', "part") is a substance or material consisting of very large molecules called macromolecules, composed of many repeating subunits. Due to their broad spectrum of properties, both synthetic and ...
(supply) consumables for small volumes (µL and mL scale), mainly sterile Laboratory equipment is generally used to either perform an
experiment An experiment is a procedure carried out to support or refute a hypothesis, or determine the efficacy or likelihood of something previously untried. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs wh ...
or to take measurements and gather
data In the pursuit of knowledge, data (; ) is a collection of discrete values that convey information, describing quantity, quality, fact, statistics, other basic units of meaning, or simply sequences of symbols that may be further interpret ...
. Larger or more sophisticated equipment is generally called a
scientific instrument A scientific instrument is a device or tool used for scientific purposes, including the study of both natural phenomena and theoretical research. History Historically, the definition of a scientific instrument has varied, based on usage, laws, a ...
.


Specialized types

The title of ''laboratory'' is also used for certain other facilities where the processes or equipment used are similar to those in scientific laboratories. These notably include: *
Film laboratory A film laboratory is a commercial service enterprise and technical facility for the film industry where specialists develop, print, and conform film material for classical film production and distribution which is based on film material, such as ...
or Darkroom * Clandestine lab for the production of
illegal drug The prohibition of drugs through sumptuary legislation or religious law is a common means of attempting to prevent the recreational use of certain intoxicating substances. While some drugs are illegal to possess, many governments regulate the ...
s *
Computer lab A computer lab is a space where computer services are provided to a defined community. These are typically public libraries and academic institutions. Generally, users must follow a certain user policy to retain access to the computers. This us ...
*
Crime lab A crime laboratory, often shortened to crime lab, is a scientific laboratory, using primarily forensic science for the purpose of examining evidence from criminal cases. Lab personnel A typical crime lab has two sets of personnel: *Field an ...
used to process
crime scene A crime scene is any location that may be associated with a committed c