LSP2-9166 is a drug which acts as a selective

agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...

for the group III

metabotropic glutamate receptor The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic receptor, metabotropic process. They are members of the group C GPCR family, group C family of G-protein-coupled r ...

s, with a reasonably potent EC₅₀ of 70nM at mGluR₄ and 220nM at mGluR₇, and weaker activity of 1380nM at mGluR₆ and 4800nM at mGluR₈. It has

anticonvulsant Anticonvulsants (also known as antiepileptic drugs, antiseizure drugs, or anti-seizure medications (ASM)) are a diverse group of pharmacological agents used in the treatment of epileptic seizures. Anticonvulsants are also used in the treatme ...

effects in animal studies, and reduces self-administration of various addictive drugs.

References

MGlu4 receptor agonists MGlu7 receptor agonists Trifluoromethyl ethers Dicarboxylic acids Alpha-Amino acids Phosphinates {{anticonvulsant-stub