LS-115509 is an

opioid Opioids are a class of Drug, drugs that derive from, or mimic, natural substances found in the Papaver somniferum, opium poppy plant. Opioids work on opioid receptors in the brain and other organs to produce a variety of morphine-like effects, ...

analgesic An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management. Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in s ...

related to the 4-phenylpiperidine family. It is comparable to drugs such as

prodine Prodine (trade names Prisilidine and Nisentil) is an opioid analgesic that is an structural analog, analog of pethidine (meperidine). It was developed in Germany in the late 1940s. There are two isomers of the trans form of prodine, alphaprodin ...

and

pheneridine Pheneridine is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine). Pheneridine is not currently used in medicine. Presumably it has similar effects to other opioid derivatives, such as analgesia, ...

, but is distinguished by the presence of an

ether In organic chemistry, ethers are a class of compounds that contain an ether group, a single oxygen atom bonded to two separate carbon atoms, each part of an organyl group (e.g., alkyl or aryl). They have the general formula , where R and R� ...

group and

furan Furan is a Heterocyclic compound, heterocyclic organic compound, consisting of a five-membered aromatic Ring (chemistry), ring with four carbon Atom, atoms and one oxygen atom. Chemical compounds containing such rings are also referred to as f ...

ring at the piperidine 4-position, which are not found in other drugs of this class. In animal studies, it has around 2-3x the potency of

morphine Morphine, formerly also called morphia, is an opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (''Papaver somniferum''). It is mainly used as an analgesic (pain medication). There are ...

depending on what assay is used. Like prodine, it has two stereocenters and four possible

enantiomer In chemistry, an enantiomer (Help:IPA/English, /ɪˈnænti.əmər, ɛ-, -oʊ-/ Help:Pronunciation respelling key, ''ih-NAN-tee-ə-mər''), also known as an optical isomer, antipode, or optical antipode, is one of a pair of molecular entities whi ...

s, but the activity of these has not been tested separately.

References

Synthetic opioids Piperidines Ethers Mu-opioid receptor agonists 2-Furyl compounds Ethoxy compounds {{analgesic-stub

See also

References