LIM domain transcription factor LMO4 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''LMO4''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its
mRNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein.
mRNA is ...
is characterized by a
GC-rich 5' region and by multiple ATTT motifs in the 3' region. A variant transcript missing a portion of the 5' region has been identified but cannot be confirmed because of the GC-rich nature of the region.
Clinical Significance
LMO4 has garnered significant attention for its involvement in cancer, particularly breast cancer. It is overexpressed in a substantial percentage of primary breast carcinomas.
Studies have shown that LMO4 can promote the proliferation of mammary epithelial cells, inhibit their differentiation, and enhance cell invasion and motility, all of which are hallmarks of cancer progression.
Interactions
LMO4 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with
LDB1
LIM domain-binding protein 1 is a protein that in humans is encoded by the ''LDB1'' gene.
Interactions
LDB1 has been shown to interact with other proteins such as LMO4, TCF3
Transcription factor 3 (E2A immunoglobulin enhancer-binding factor ...
,
RBBP8
Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the ''RBBP8'' gene.
Function
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to ret ...
BRCA1
Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the ''BRCA1'' () gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene. ''BRCA1'' is a ...
.[
]
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
{{Gene-1-stub