LETM1-like is a
family of evolutionarily related proteins.
This is a group of mainly hypothetical
eukaryotic proteins. Putative features found in LETM1, such as a
transmembrane domain and a CK2 and PKC
phosphorylation
In chemistry, phosphorylation is the attachment of a phosphate group to a molecule or an ion. This process and its inverse, dephosphorylation, are common in biology and could be driven by natural selection. Text was copied from this source, wh ...
site,
are relatively
conserved throughout the family.
Deletion
Deletion or delete may refer to:
Computing
* File deletion, a way of removing a file from a computer's file system
* Code cleanup, a way of removing unnecessary variables, data structures, cookies, and temporary files in a programming language
* ...
of LETM1 is thought to be involved in the
development of Wolf-Hirschhorn syndrome in
humans.
A member of this family
SWISSPROT is known to be
expressed in the
mitochondria
A mitochondrion (; ) is an organelle found in the Cell (biology), cells of most Eukaryotes, such as animals, plants and Fungus, fungi. Mitochondria have a double lipid bilayer, membrane structure and use aerobic respiration to generate adenosi ...
of ''
Drosophila melanogaster'',
suggesting that this may be a group of
mitochondrial
A mitochondrion (; ) is an organelle found in the cells of most Eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is use ...
proteins.
Examples
Human gene encoding members of this family include:
*
LETM1,
LETM2,
LETMD1
References
{{InterPro content, IPR011685
Protein families