L-2-hydroxycarboxylate dehydrogenase (NAD
+) (, ''(R)-sulfolactate:NAD
+ oxidoreductase'', ''L-sulfolactate dehydrogenase'', ''(R)-sulfolactate dehydrogenase'', ''L-2-hydroxyacid dehydrogenase (NAD
+)'', ''ComC'') is an
enzyme
An enzyme () is a protein that acts as a biological catalyst by accelerating chemical reactions. The molecules upon which enzymes may act are called substrate (chemistry), substrates, and the enzyme converts the substrates into different mol ...
with
systematic name
A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivi ...
''(2S)-2-hydroxycarboxylate:NAD+ oxidoreductase''.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the chemistry, chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an Gibbs free energy, ...
: (2S)-2-hydroxycarboxylate + NAD
+ 2-oxocarboxylate + NADH + H
+
The enzyme from the
archaeon ''
Methanocaldococcus jannaschii
''Methanocaldococcus jannaschii'' (formerly ''Methanococcus jannaschii'') is a thermophile, thermophilic methanogenic archaean in the class Methanococci. It was the first archaeon, and third organism, to have its complete genome genome sequencing ...
'' uses as a substrate multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-
malate
Malic acid is an organic compound with the molecular formula . It is a dicarboxylic acid that is made by all living organisms, contributes to the sour taste of fruits, and is used as a food additive. Malic acid has two stereoisomeric forms ( ...
, (S)-
lactate, and (S)-2-hydroxyglutarate.
References
External links
*
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