Skeletal formula of kynapcin-24
Kynapcin is a general name for a number of
dibenzofuranyl
derivatives
The derivative of a function is the rate of change of the function's output relative to its input value.
Derivative may also refer to:
In mathematics and economics
* Brzozowski derivative in the theory of formal languages
* Formal derivative, an ...
of the molecule
polyozellin
Polyozellin is a chemical which occurs in the mushroom ''Polyozellus multiplex''. It enzyme inhibition, inhibits prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's diseas ...
, present in the fungus ''
Polyozellus multiplex
''Polyozellus multiplex'' is a species of fungus first described in 1899, and is commonly known as the blue chanterelle, the clustered blue chanterelle, or, in Alaska, the black chanterelle. The distinctive fruit body of this species comprise ...
''. Like polyozellin, some kynapcins
inhibit prolyl endopeptidase
Prolyl endopeptidase (PE) also known as prolyl oligopeptidase or post-proline cleaving enzyme is an enzyme that in humans is encoded by the ''PREP'' gene.
Function
Prolyl endopeptidase is a large cytosolic enzyme that belongs to a distinct cla ...
, an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that has a role in processing proteins including
amyloid precursor protein
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many biological tissue, tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor and has been implicated as a regulator ...
. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.
Several kynapcins have been found in ''P. multiplex'', each with different
chemical properties, including kynapcin-12,
kynapcin-13 and -28,
and -24. A
total synthesis of kynapcin-24 was achieved in 2009.
References
Benzofurans
Methyl esters
Catechols
{{organic-compound-stub
